Abstract:DESCRIPTION (provided by applicant): Early identification of developmental problems and delays means that interventions can begin sooner and are more effective and less resource-intensive than later interventions, after a problem has festered and worsened.Despite these benefits, statistics indicate… more
Abstract:DESCRIPTION (provided by applicant): There is no more important target audience for smoking cessation efforts than pregnant women. The goal of this Fast Track project is to establish the scientific and technical feasibility of using an interactive text- and web-based application to support smoking… more
Abstract:Aim 1: Concept Testing: To elicit qualitative feedback from adolescents age in recovery, ages 15-18, in a focus group format (n=9) on the concept of Recovery Warrior and the proposed design features of Recovery Warrior. PUBLIC HEALTH RELEVANCE
Abstract:DESCRIPTION (provided by applicant): There is a very large and rapidly growing unmet need for disease-modifying drugs for Alzheimer's disease (AD) as its prevalence is increasing worldwide due to demographic shifts in the aging population. AD is the thirdmost costly disease in the US with… more
Abstract:CMOS-Integrated Fluorescence Biochip Arrays Abstract Array technologies have been responsible for a multitude of discoveries in genomics and proteomics. However, they require sophisticated and highly accurate instrumentation. Today, the bulkiness, cost, and complexity of array readers have become… more
Abstract:Diabetes is an epidemic disease in the United States and worldwide. Diabetes care accounts for 10% of all U.S. healthcare costs, most of which is consumed in the care of complications from diabetes, but also includes lost economic productivity from illness, disability and blindness. Despite the high… more
Abstract:DESCRIPTION (provided by applicant): Treatment of Human papillomavirus (HPV) infections is a major unmet medical need. Importantly, the licensed HPV vaccines are not able to clear existing infections, and there are now multiple FDA-approved tests to detecthigh risk HPV DNA, and specifically HPV16.… more
Abstract:DESCRIPTION (provided by applicant): Successful management of HIV1 infection with anti-retroviral therapy (ART) is critically dependent on choosing effective drugs. The spread of drug resistance HIV mutations poses a challenge (1-3) and drug resistance testing (DRT) has become an integral part of… more
Abstract:DESCRIPTION (provided by applicant): There is a need to be able to deliver just-in-time training and reference materials for first responders and skilled support personnel. Mobile computing platforms are becoming ubiquitous and provide an ideal means to reach users at any time in any location. The… more
Abstract:This Small Business Innovation Research Phase I project addresses separation needs of biopharmaceutical manufacturers by developing novel membranes with exceptional performance. Currently available membranes used to separate therapeutic proteins suffer from broad pore size variations, resulting in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is focused on the demonstration of a real-time high-contrast Terahertz (THz) imaging system, based on frequency upconversion of THz images into the near infrared (NIR) spectral range. Due to low power of compact THz sources and poor… more
Abstract:Unmanned Aerial System (UAS) operation represents a stressful, cognitively challenging domain where operators are routinely subjected to both occupational and combat stressors and performance failures can have catastrophic effects. Effective performance in such conditions has many dimensions,… more
Abstract:The synthesis of ammonia through nitrogen fixation is a vital component to all plant life and the world economy as a fertilizer and commodity chemical. The global industial production of ammonia exceeded 140MM tons in 2009 and is expected to grow to 160MM tons by 2020. Most ammonia,>90% is… more
Abstract:Registries offer an important way to collect uniform data with a view toward understanding the etiology of diseases, and to improving their treatment. A major constraint in establishing registries is the cost of data acquisition, especially when not available from existing sources. The CDC SB EMR is… more
Abstract:Recently, the availability of the high performance rare earth based magnets (Nd-Fe-B and Sm-Co) was jeopardized due to the Chinese monopoly of rare earth production, which undermines our national security and competitiveness in the defense and clean energy sectors and creates a strategic… more
Abstract:DESCRIPTION (provided by applicant): PROJECT SUMMARY Although prophylactic vaccines have potential for prevention of high risk human papilloma virus (HPV) infection they have no therapeutic efficacy. It has been estimated that there will be no measurable decline of HPV- associated tumors before 2040… more
Abstract:Teen pregnancy rates remain high particularly among racial/ethnic minority youth and age of onset for sexual activity has decreased significantly in recent years. As young teenagers initiate dating and sexual activity during the years of middle school, there are often few resources available for… more
Abstract:ABSTRACT: This project aims to develop a Short Wave Infrared band image projector to provide real time detector stimulation with high dynamic range. Our emitter technology is based on GaInAsSb quaternary semiconductor LED arrays hybridized to CMOS read-in integrated circuits. This project leverages… more
Abstract:PROJECT SUMMARY/ABSTRACT My Coverage Plan Inc. (MCP) proposes to use our newly patented technology to create a commercially viable and nationally replicable suite of software and services for health care providers and other social service agencies that reduces avoidable health disparities and… more
Abstract:DESCRIPTION (provided by applicant): Three novel uncharged silver microbicides have been shown to be effective against a wide variety of pathogens have been shown to spontaneously form amorphous hydrogels when combined with glutathione will be formulated into two different ointment formulations and… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project is to develop an inexpensive and rapid sensing technology for detection of tuberculosis (TB) at the point of care (POC). Rapid screening of TB in rural areas is difficult because current diagnostic methods are expensive, time consuming… more
Abstract:ABSTRACT: This Small Business Innovation Research Phase II project will develop novel nonlinear filtering and joint decision and estimation methods for robust and persistent tracking of multiple targets with nonlinearities in measurement and dynamic model. The key innovations in this effort include… more
Abstract:ABSTRACT: Current video feeds from airborne sensors such as Predator, Argus-IS, Argus-IR, Gorgon Stare and others excel at providing high resolution imagery from a birds-eye vantage point. While those pixels offer the analyst the eye-in-the-sky, today's systems rely on the analyst to interpret… more
Abstract:The ability to readily and rapidly detect the concentration of the 9- and 12-amino acid oxytocin analogs will significantly enhance the efficacy of understanding the conditions under which oxytocin is employed by the body. Ionica Sciences will take advantage of recent miniaturization of highly… more
Abstract:The response of an object to a burst of electromagnetic energy consists of an early-time skin response (radar cross section or RCS) and late-time (target resonance or TR) returns. Measurements of these target characteristics may be integrated and exploited in the signal/data processor for… more
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