Abstract:This Small Business Innovation Research Phase I project relates to the use of nano-structured chemicals in the processing of light-weight magnesium (Mg) alloys for high performance applications. It is postulated that reactive nano-structured chemicals such as polyhedral oligomeric silsesquioxane… more
Abstract:The US Department of Energy (DOE) has reported that the wave energy resource available in the US has the potential to power over 100 million homes each year, and the DOE is currently developing an aggressive strategy to support its vision of providing 15% of our nations electricity needs from water… more
Abstract:Diesel compression ratios are normally set high (16:1 to 23:1) for cold starting, yet data show optimum fuel efficiency and emissions occur at compression ratios below 14:1. The industry trend has been to steadily reduce compression ratio. Literature findings indicate that reducing Diesel… more
Abstract:Diesel engine manufacturers need a way to improve fuel economy as well as limit NOx and particulate emissions to meet upcoming federal, state, and global regulations. A large percentage of emissions and fuel consumption occurs during cold start and light to medium load operation. EMA proposes to… more
Abstract:Mine countermeasures (MCM) missions require complex coordination of personnel, equipment, and autonomous vehicles. The mission success hinges on timely and accurate decision-making for responding to dynamic situations in the area of operations that pose considerable risks to mission assets; both… more
Abstract:Unmanned systems have proven their value in combat operations by delivering unprecedented mission performance. Unfortunately, the current unmanned systems are predominantly tele-operated, which tie up many skilled operators per unmanned system. Thus, increasing demands for unmanned system cannot be… more
Abstract:In this Phase II effort, SK Infrared LLC, is collaborating with Raytheon Vision Systems (RVS) to demonstrate a dual color 512x512 30 um pitch long wave/long wave (LW/LW) pBp focal plane array (FPA) hybridized to a RVS SB410 Read Out Integrated Circuit (ROIC). The SB410 is a 512x512 30 micron pitch… more
Abstract:This Small Business Innovation Research Phase I Project proposes to develop a novel non-invasive diagnostic imaging tool for the early detection of skin cancer. In this project, a controlled temperature stimulus is applied to the suspected lesion and the thermal recovery process is captured with an… more
Abstract:A Compact Bidirectional Acoustic Airflow Meter has been developed for gas turbine and other applications. Phase I work has resulted in a non-intrusive meter capable of reading gas flows at high speed in either direction, with a dynamic range exceeding 1000:1. A ruggedized, high-temperature version… more
Abstract:DESCRIPTION (provided by applicant): Standard Imaging, Inc. is developing a new generation of radiation dosimeters for small field dosimetry. These small detectors are needed in clinical applications such as stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT), intensity modulated radiation… more
Abstract:DESCRIPTION (provided by applicant): There is a critical need to improve the accuracy of preclinical drug efficacy and toxicity screening and testing through the development of human hepatocyte (liver) in vitro culture systems that more effectively mimic the human in vivo environment. HemoShear is a… more
Abstract:DESCRIPTION: Drug candidates that disrupt the NEMO/IKK signaling complex for the treatment of cancer Project Summary/Abstract Protein-protein interactions represent the largest untapped opportunity for therapeutic development, but the field has languisheddue to lack of efficient lead finding… more
Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR will develop Continuous Real Time (CRT) ShuntCheck, the first portable, non- invasive device for real time, continuous monitoring of changes in flow in CSF shunts. This device will result in improvedclinical management of hydrocephalus by… more
Abstract:The project team is developing a prototype of the Readorium Rising Reader, a web-based game for students in grades 3 to 5 intended to strengthen reading comprehension of non-fiction science text. The game will provide students with strategies to use as they construct meaning and decipher new… more
Abstract:DESCRIPTION (provided by applicant): The goal of the current project is to revise a prototype of a computerized attention training program (Amplified Attention Training, AAT) for hemispatial neglect completed in Phase I, and conduct a multi-site, randomized, controlled trial to establish efficacy in… more
Abstract:DESCRIPTION (provided by applicant): A large body of evidence indicates that the cognitive impairment and delayed neurodegeneration in traumatic brain injury (TBI) is caused by increased accumulation of tau, phosphorylated tau (p-tau) and other neurotoxic proteins including APP and… more
Abstract:DESCRIPTION (provided by APPLICANT): An overlooked, neglected, yet significant problem in the United States today is the use and abuse of tobacco, alcohol, and other drugs by individuals with intellectual disabilities (ID). Increasing numbers of people with ID are living independently in the… more
Abstract:ABSTRACT: Mycotoxins are toxic secondary metabolites of molds and fungi, many of which are pathogenic to humans. In general, mycotoxins enter the body through the skin, digestive tract, or through respiration. Exposure to a few milligrams can be lethal. Mycotoxins have a high likelihood of … more
Abstract:Communication SoC technology has advanced significantly over the past ten years resulting in highly integrated radio SoC chips for standards such as Wi-Fi, global position system (GPS), Bluetooth (BT), 3G cellular, digital TV (DTV), and cable modems. While most radio SoC"s are narrowband (e.g.… more
Abstract:ABSTRACT: Recent demand for broadband satellite communications (SATCOM) has risen sharply for both the defense and commercial sectors. Tactical SATCOM, such as WGS, require increasingly broadband information contents such as high resolution surveillance images and videos, while on the other hand,… more
Abstract:DESCRIPTION (provided by applicant): Yearly influenza epidemics affect about 5 - 15% of the world's population and estimates of annual mortality range from 250,000 - 500,000, including approximately 30,000 deaths and 200,000 hospitalizations in the UnitedStates. In addition, the likelihood of a… more
Abstract:Washburn Therapeutics Inc. is developing biologically active gels that control inflammation by selectively neutralizing pro-inflammatory cytokines based on a technology being licensed exclusively by the company from Carnegie Mellon University. Preliminary results demonstrated that conjugates of… more
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