Abstract:Following ablative surgery for thyroid cancer, follow-up management of patients includes monitoring for radioiodine uptake or serum TG levels. Recombinant human thyroid stimulating hormone (rhTSH) is currently used to increase the sensitivity of measurements in patients on thyroid hormone … more
Abstract:This technology introduces a new non-invasive, biopsy-adjunct with a MNP platform for targeted tumor delivery. It employs closely sized magnetic nanoparticles (CS-MNP's) for determining their concentration and spatial distribution in tumor vasculatures asmeasured by magnetic resonance imaging… more
Abstract:Surgical resection of malignant tumors is the single most effective therapy for cancer. Long-term patient outcomes are strongly determined by the extent to which the surgeon can completely remove all diseased tissues. Present cancer imaging and detectionmethods often fail to provide a clear… more
Abstract:TP-0413 is a novel small molecule inhibitor of the BMP pathway that has significant potential to be developed to treat anemia of cancer. Anemia of cancer is cytokine driven and results in the up-regulation of a liver hormone called hepcidin through the function of BMP receptors. Increased hepcidin… more
Abstract:Cancer is a leading cause of death that affects millions of lives across the world. It is a complex disease that is likely to require multifactorial measurements for earlier and more accurate diagnosis and patient stratification. Tissue biopsies and fine needle aspirates are commonly collected… more
Abstract:The Hsp90 inhibitor 17-DMAG will be encapsulated in a nano-sized liposome formulation that is long-circulating with controlled drug release properties in tumor tissue. Reformulation of 17-DMAG in a nanoliposome will increase the dose intensity of 17-DMAG in solid tumors while reducing the hepatic,… more
Abstract:This project aims to develop a stabilized epothilone B (Epo B)-loaded micelle for the intravenous delivery of Epo B to solid tumors. The data should demonstrate that Epo B is encapsulated within the micelle with weight-loadings in the range of 1-5% wt/wt Epo B. Crosslinking chemistries will be… more
Abstract:The aim of this project is to reformulate a highly lipophilic anti-cancer agent, valrubicin (AD-32) that has only been approved for vesicular treatment of bladder cancer due to its poor dose limiting toxicities due to poor water solubility. LipoMedics willreformulate valrubicin (AD-32) utilizing a… more
Abstract:To modify the Contractor's ID-Cap medication adherence system to add biometric identification and secure communication systems that enable compliance improvement programs. Thr result is that it can allow for accurate, real-time monitoring of medication adherence with no effort by the patient.… more
Abstract:We have entered a stage where there are plentiful of therapeutic agents either in clinical use or in development for clinical use. The difficulty is not in finding drugs for treatment, but to tailor fit treatment to the patients- personalized medicine. Personalized medicine demands both… more
Abstract:Cardiovascular disease is a leading cause of morbidity and mortality and both high LDL-C and low HDL-C remain validated factors that predict and contribute to risk. Reliance on the lipid, cholesterol, as the surrogate marker to measure total LDL and HDL has limitations and provides inadequate… more
Abstract:Folic acid is a water-soluble vitamin that serves as a cofactor in 1-carbon transfers required for DNA replication. Humans lack the enzymes to synthesize folate, so dietary intake is necessary. Its deficiency is associated with neural tube defects (NTDs) in fetuses. The global burden of folate… more
Abstract:Breast, cervical, and colorectal cancer can be successfully prevented and/or diagnosed and successfully treated at the earliest stages through use of appropriate and timely screening and adequate follow-up and care coordination. Recognizing the importance of cancer screening, groups like the… more
Abstract:A rapid respond to outbreaks critically depends on laboratory confirmation of suspected measles cases. In general, the turnaround times for serologic test results provided by the WHO Measles/Rubella Laboratory Network are adequate; however, results from specimens collected in remote areas can be… more
Abstract:The proposed research plan will start at a TRL 1 and commence with the collection of dynamic recoil response field data using a firearm and
ammunition chosen by the DHS for testing. Data will be collected for a firearm operator that classifies as a 90th percentile male, and an operator… more
Abstract:Capacitive energy storage is a critical technology for advanced electronics as well as a necessary technology for the implementation of intermittent, renewable power generation. Innovative and scalable nanofabrication techniques are required to enhance the performance and energy density of… more
Abstract:A significant challenge faced by space-bound experiment packages is the requirement for a minimally controlled environment while a small payload is awaiting launch or is in transit to the International Space Station (ISS). NASA is seeking thermal solutions for the transportation of NanoRack and… more
Abstract:This proposal details the method of fabrication for a hierarchical hybrid nanomaterial for oxygen storage vessels. These vessels exceed the volumetric and gravimetric storage capacity of an oxygen cylinder by 330% and 215%, respectively. It is estimated that this oxygen storage device will weigh… more
Abstract:Mainstream Engineering Corp. (MEC) proposes developing a pyrolytic solid waste remediation system (py-SWRS) for processing mixed solid waste at small contingency base camps. The proposed py-SWRS unit is a scaled-down and simplified version of a portable pyrolysis reactor already under development at… more
Abstract:ABSTRACT: A new generation of supersonic weapons will operate at Mach 3-6. Current radome materials are unable to withstand the heat generated at the temperatures associated with hypersonic flight. Mainstream Engineering is proposing an advanced cooling approach that helps to extend the performance… more
Abstract:ABSTRACT: Using solar energy to drive air conditioning systems is logical since the sun is present when air conditioning is needed the most. Unfortunately, the payback period for installing photovoltaic solar cell arrays to electrically drive the air conditioning system is unacceptably long, at… more
Abstract:Mainstream Engineering Corp. (MEC) proposes developing a diesel engine-generator with nanostructured high-zT thermoelectric exhaust waste heat recovery. Commercially available thermoelectric materials have a thermoelectric figure of merit (zT) of approximately 1. Published efforts to harvest exhaust… more
Abstract:Currently, diesel generators are typically used to supply electrical power to soldiers in the field. Diesel generators suffer from wet stacking at partial loads, high fuel costs and resupply logistics, and high transportation risk. The development of a portable wind power generating system capable… more
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