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Year:2012
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Displaying 5526 – 5550 of 5641 Awards
Company: QUSPIN Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this project is to develop a very low-cost whole-head neonatal MEG system that can adapt to the shape and size of the head. Clinically, there is a longstanding need for a technology that can aid in the diagnosis and prognosis of babies with brain… more
Company: QUSPIN Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this project is to develop a low cost, non-invasive system for diagnosis of serious heart rate and rhythm abnormalities in fetus. Postnatally, electrocardiography (ECG) is the gold standard for rhythm assessment. In the fetus, however, the quality of… more
Company: OP-T-MUNE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this application is to develop a test kit to quickly and accurately diagnose type 1diabetes; differentiate it from type 2 diabetes and screen for pre-diabetes . Current screening methods involve multipleblood tests, HLA haplotype and the presence… more
Company: CINLANIAN BIOTECHNOLOGY, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): 5-Hydroxymethylcytosine (5-hmC) is a newly identified base modification in mammalian genomic DNA. Because current sequencing methods cannot differentiate 5-meC from 5-hmC, the immediate challenge is to develop robust methods to ascertain the positions of 5-hmC… more
Company: GENAPSYS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: Advances in Next Generation Sequencing (NGS) have greatly accelerated fundamental life science research but additional breakthroughs in technology are required to allow routine use of sequencing in the clinical setting for personalized medicine as a disease diagnostic, prognostic and therapeutic… more
Company: SAGE SCIENCE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The overall goal for the proposed SBIR program is to develop an instrument system that can accept whole blood as an input sample and produce a genomic DNA library suitable for next- generation DNA sequencing (NGS). Allsteps, from DNA extraction to final library… more
Company: 23ANDME, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): In June 2011, the FDA hosted a public meeting: Ultra High Throughput Sequencing for Clinical Diagnostic Applications - Approaches to Assess Analytical Validity (FDA Public Meeting, 2011). The background documentation for this meeting noted that In order to… more
Company: 23ANDME, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): 23andMe is a personal genomics company with a mission of accelerating medical discoveries by empowering consumers to participate in research. At the heart of this mission is the 23andMe research engine, a novel platform for conducting genetic studies that allows… more
Company: 23ANDME, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Genetics of Allergic Disease in a Participatory Research Cohort Asthma and allergic disease are extremely common conditions with substantial public health burdens, affecting as many as one in five Americans. Discovery of genetic variants affecting allergic… more
Company: CYLERUS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The Company's business and research efforts are focused on developing and commercializing a novel drug delivery approach to prevent the abnormal ingrowth of tissue (intimal hyperplasia) that can block the flow of bloodthrough artificial blood vessels… more
Company: HEMEMICS BIOTECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Although platelets are a critical component in hemostasis, current methods for platelet storage severely limit their utility as a lifesaving blood component. In related work conducted to date, we have developed methodsto preserve mammalian cells in desiccated… more
Company: NANOCOR THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Congestive heart failure is a major cause of morbidity and mortality in the United States. While progress in conventional treatments is making steady and incremental gains to reduce heart failure mortality, there is a critical need to explore new therapeutic… more
Company: MED-CONDUIT, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The survival of patients with end-stage renal disease (ESRD) on hemodialysis is largely dependent upon the maintenance of vascular access. Yet catheter related blood stream infection remains one of the most important causes of sepsis and repeat hospital… more
Company: ACCEL DIAGNOSTICS Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: ****NOTICE: ABSTRACT EXTRACTED FROM APPLICATION FOR REPORTING CATEGORIES AND DISEASE CODING (RCDC). THIS TEXT HAS NOT BEEN PROOFED BY SRA. WHEN THE UPLOADED ABSTRACT IS NOT IN THE EXPECTED FORMAT, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE.**** Project Summary: The overall goal of the… more
Company: EMPHYMAB BIOTECH, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Emphysema is a prevalent chronic obstructive pulmonary disease (COPD) induced predominantly by cigarette smoking through a complex mechanism that includes excessive apoptotic cell death of alveolar lung structural cellsand chronic inflammation and for which there… more
Company: RHEOMICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Population studies and drug research require a high-throughput measurement of clot stiffness, permeability. The single largest cause of death in the US over the latter half of the 20 century was and still is a thrombotic event: a clot in the heart, brain, or… more
Company: VIVAQUANT, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): In-band artifact and noise present a major obstacle to extracting accurate, reliable, and repeatable information from ambulatory recordings of subcutaneous and surface ECGs. With more than 4 million patients a year experiencing ambulatory evaluations for cardiac… more
Company: CIRCADIAN MANAGEMENT, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): ZircLight: Spectrum-Specific Lighting for Shift Work Epidemiologic evidence has established that shift work exposure is associated with an array of adverse health consequences, including increased risk of cardiovasculardisease, gastrointestinal disease, and… more
Company: PROLUDE MEDICAL, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): ProHealing Drug Alternative for Coronary Drug Eluting Stents Our goal is to develop a novel, safer and more efficacious approach for treating Coronary Artery Disease, by incorporating a modulator of growth factor activity, PRM-100, within a Drug Eluting Stent… more
Company: FGH BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The Specific Aim of this proposal is to test the feasibility of using an orally available small molecule (FGH10019) to reduce obesity. Obesity contributes to the prevalence of many disease states and accounts for more than 25% of all health care costs in the US… more
Company: KOGNITO SOLUTIONS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Childhood obesity is a serious public health issue with significant health risks and high medical costs. Using motivational interviewing (MI) around nutrition and physical activity in the context o an office visit has shown positive results in terms of… more
Company: ORPRO THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Effective management of obstructive pulmonary diseases, especially Cystic Fibrosis (CF), represents a significant unmet medical need. Such diseases are characterized by thickened mucus that contributes to impaired lungfunction. This mucus barrier is composed… more
Company: NOVERATECH, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The specific aims of this proposal are to use a newly developed intracellular energy delivery technique to enhance resuscitation, and to study the relationship between tissue high-energy phosphate supplementation and tissue necrosis and apoptosis during… more
Company: PARAGONIX TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Organ preservation and safe transport is a critical factor in transplantation medicine, but adequate preservation of human organs donated for transplantation poses a significant challenge. While significant progress hasbeen made in defining the principles… more
Company: RETIA MEDICAL, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Cardiac output (CO) monitoring can improve the outcomes of critically ill patients via early detection and diagnosis of disease and goal-directed therapy. Yet, CO monitoring has sharply declined due to its invasiveness.Retia Medical will offer a device that… more
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