Abstract:DESCRIPTION (provided by applicant): DNA damage threatens the longevity and functionality of cells, and is common to the pathogenesis of many diseases. Better tools are needed for clinical identification and research into mechanisms underlying DNA oxidation, deamination, and hyper/hypomethylation,… more
Abstract:Global analysis of serum lipoprotein subclasses requires a platform that measures size distributions of lipoprotein particles identified by apoprotein content. We propose to employ an innovative methodology based on superparamagnetic and birefringent nanoparticles that bind to supramacromolecular… more
Abstract:This proposal for a Ka-band Spread Spectrum terminal presents a unique affordable design approach for On-the-move satellite communications. Over the past 5 years Alico Systems has been involved in the design and development of low cost phased array antennas for the DoD. Our most recent product for… more
Abstract:The overall objective of the program is to develop innovative concepts for more efficient and reliable clutch plates for the JSF Fan Duct Clutch. Carbon-carbon composite clutch plates can meet a 1,500 engagement life requirement for a lift fan clutch, but this is at least two times less than the… more
Abstract:Advanced ceramic matrix composites (CMC) are required for various components in the propulsion system along the hot gas path, where pressures up to 3000 psi and flame temperatures from 4000 degrees F to 5000 degrees F are encountered. In order to achieve the lightest possible and optimal component… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop a novel quantitative particle agglutination technology for improving the performance of assays for detection of allo-antibodies to red blood cell antigens. Theconventional hemagglutination blood typing… more
Abstract:DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction.… more
Abstract:ABSTRACT: The objective of this Phase I SBIR effort is to develop and demonstrate a multifunction, multi-beam X-band subarray that is capable of simultaneously supporting communications for satellite operations and radar for air/space surveillance. Under this proposed effort, Alpha Omega… more
Abstract:The Phase II STTR technical objective will update, expand, and validate the excellent results achieved in the Phase I"Analysis and Modeling of Foreign Object Damage (FOD) in Ceramic Matrix Composites (CMC"s)"program. The program will evaluate CMC component life capability before and… more
Abstract:A composite software design tool kit is proposed to predict composite properties using micro-mechanics augmented lamination theory. The capability will overcome shortcomings of progressive failure models and will take into account translaminar and interlaminar failure mechanisms. Starting from… more
Abstract:Although biodiesels have been increasingly used in automobiles, trains, commercial aircrafts and heating systems, they are not currently used in the military aircrafts and land vehicles because they typically do not meet the JP-8 performance criteria as specified by MIL-PRF-83133E. Unintentional… more
Abstract:In this SBIR program, AlphaSense, Inc. teamed with the Center for Non-destructive Evaluations at Iowa State University to develop a compact, low cost handheld sensor for non-destructive material case depth verification. In phase I, we have proven the feasibility of using an alternating current… more
Abstract:DESCRIPTION (provided by applicant): Vasculox, Inc. is developing a humanized anti-CD47 mAb for reducing ischemia-reperfusion injury (IRI) in organ transplantation. In spite of improvements in surgical technique, organ preservation and immunosuppression, IRI remains a serious limitation and is… more
Abstract:Life cycle analysis of biofuel production from lignocellulosic biomass combined with carbon capture has shown the potential to produce negative greenhouse gas emissions. More than a billion dry tons of freshly harvested lignocellulostic biomass is available at moisture contents between 20 and 60%. … more
Abstract:Under the proposed project Altex will develop a Solid Waste Remediation System (ASWRS) for onsite disposal of bulk solid wastes generated at Patrol Bases (PBs) or Combat Outposts (COPs). The system is designed to recover heat and use innovative approaches to dispose of the waste in an efficient and… more
Abstract:ABSTRACT: Aircraft electromechanical actuators are dispersed throughout the aircraft and cannot utilize existing ECS or PTMAS for cooling. They must be cooled by passive thermal management system to maintain component reliability and longevity, particularly in high ambient temperature environments.… more
Abstract:Altex Technologies and the Pennsylvania State University propose the BioPure-FC biogas purification system, which is designed to purify biogas from landiflls and wastewater-treatement plants to levels compatible with fuel-cell systems. PSU's novel sorbents combined with Altex's… more
Abstract:Airborne high energy laser thermal management systems need lightweight and compact radiators. An innovative radiator heat exchanger concept has been identified, which can help reduce thermal management system weight and volume, to below 100 lbs and 8 cubic feet, respectively, while also reducing… more
Abstract:Junior infantry need usable tools and methods for collecting and interpreting significant information about the local economic environment through observation and questioning, and for developing daily tactical courses of action based on those interpretations. Altusys will lead a multidisciplinary… more
Abstract:DESCRIPTION (provided by applicant): Functional RNA molecules such as aptamers, siRNAs, miRNAs, and related compounds have enormous potential as human therapeutics and as tools for elucidating gene regulation in vivo. To reach this potential, such molecules must be highly potent and highly nuclease… more
Abstract:The DARPA is seeking rapid innovative manufacturing for turbine components in Vulcan Program. We, at UTRON Kinetics, propose a modern rapid Combustion Driven Advanced Powder Compaction Manufacturing to fabricate simple and complex shapes of various refractory alloys and composites using Mo-Re, with… more
Abstract:In response to MDA"s innovative manufacturing approaches, we propose to fabricate and evaluate high strength, higher temperature W-25Re base alloys and their select composite materialsof Hf, HfC, TaC for erosion resistant throats (for second or third stage rocket motors. Required number of… more
Abstract:We propose in Phase II effort to continue and further optimize and scale up to fabricate the large diameter fragmenting test cylinders/complex geometries using innovative and Cost-effective Combustion Driven Rapid Powder Compaction Manufacturing as a follow-up of the successful development and… more
Abstract:DESCRIPTION (provided by applicant): There is an urgent need for early-detection cancer biomarkers which can significantly lower the high mortality and cost of treating cancer. One of the most promising candidates for such biomarkers is tumor-associated autoantigens (TAA), autoantibodies to which… more
Abstract:DESCRIPTION (provided by applicant): This proposal focuses on the development of a high-throughput, high sensitivity, low blood-volume, multiplex system for in vitro diagnosis of pediatri food allergies. Allergies comprise a group of immune disorders constituting the 6th leading cause of chronic… more
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