Abstract:This Small Business Innovation Research project will develop a non-animal based in vitro assay for determining the efficacy of Botulinum (BoNT) neutralizing therapeutics. New technologies are currently needed in order to facilitate the development and approval of BoNT vaccines and therapies and… more
Abstract:DESCRIPTION (provided by applicant): Unknown or poorly understood differences in the potency of therapeutics containing the botulinum neurotoxin Type A (BoNT/A) could result in over or under dosing of patients. The potency of BoNT/A therapeutics is currently assessed using a mouse intraperitoneal… more
Abstract:DESCRIPTION (provided by applicant): Clinical laboratories (CL) practitioners play a crucial role in the detection, diagnosis, and treatment of disease, trauma, and maladies. In fact, 70% of the information used by health care practitioners in making medical decisions comes from the CL. However,… more
Abstract:In our Phase I effort, we propose to develop a technique for passively enhancing target scene object orientation detection for support of post-flight reconstruction. This passive solution will enable dynamic rate reconstruction for pitch, yaw, and roll at rates that range from sub-Hz to 100s of Hz.… more
Abstract:We will apply the test methods that we have developed to assess the performance of Ballistic Missile Defense interceptors in the presence of natural and man-made radiation environments. At the conclusion of Phase II, MDA will have a demonstrated hardware-in-the-loop capability to test the kill… more
Abstract:This Small Business Innovation Research Phase I project attempts to overcome fundamental limitations that are currently inhibiting the realization of much needed low-cost high-performance digital-to-analog converters (DACs), which can accommodate the wide bandwidths of current and future… more
Abstract:This Small Business Innovation Research Phase 2 project targets the realization of a cost-effective solution for achieving increased data throughputs in the crosstalk-constrained copper-medium-based cellular and access backhaul networks, to address the growing demand for capacity experienced in them… more
Abstract:The Urban Forestry Modeling and Prioritization Tools project addresses the research and tasks necessary for creating cost effective, web-based software that assists urban foresters with strategically selecting planting locations in order to maximize impact on both the environment and local… more
Abstract:Nylon fabric is a polyamide that is lightweight, strong and durable. The fabric dries quickly when wet and provides comfort. Nylon is used in multiple applications ranging from apparel, home furnishings, industrial applications and geo-textiles. The cloth specified by this proposal is Mil-C-… more
Abstract:A growing body of research underscores the need to prepare students socially—as well as academically—to ensure successful transition to middle school and foster subsequent academic success. This project team is developing a prototype of a series of web-based interactive games to help students… more
Abstract:DESCRIPTION (provided by applicant): The Advanced Biofidelic Lower Extremity Kids prosthesis (ABLE Kids) project will advance the state-of-the-art of pediatric prosthesis systems by advancing the demonstrably successful Phase I device and refining it intoan ultracompact and lightweight form factor… more
Abstract:DESCRIPTION (provided by applicant): Stiffness and alignment of ankle-foot orthoses (AFOs) should be tuned optimally to maximize their function. Improperly tuned AFO may induce joint pain, reduced ambulatory function, and increased medical complications for patients with stroke. Therefore, the… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project focuses on the further development of an advanced, mobile, easy-to-use, patient-oriented, advanced Home Hemodialysis (HHD) system that minimizes the use of water (less than 6 liters) and medical waste, and importantly, minimizes… more
Abstract:DESCRIPTION (provided by applicant): Over the past several decades, a large number of mental health (MH) practices and interventions have been rigorously tested through randomized control trials and shown efficacious. However, despite availability, evidence-based interventions (EBIs) are rarely… more
Abstract:DESCRIPTION (provided by applicant): Clinical science and its translation into preventive and clinical patient care are the primary means by which the nation's health care goals are fulfilled. NIH's broad mission to improve health outcomes for all people can only be achieved if scientific… more
Abstract:DESCRIPTION (provided by applicant): Non-suicidal self-injury (NSSI) is an increasingly common self-harming behavior among adolescents and young adults, with current estimates of NSSI in youth ranging from 12-37%. Although NSSI is associated with other mental health problems (e.g., depression,… more
Abstract:DESCRIPTION (provided by applicant): Although high school success and completion are among the most important determinants of future life outcomes, over half a million adolescents in the United States drop out of school each year. School dropout has negative individual (e.g., increased likelihood of… more
Abstract:DESCRIPTION (provided by applicant): As emphasized by the NIH Roadmap and NCRR's Strategic Priorities, NIH's broad mission to improve health outcomes for all persons depends on the ability to train and retain future generations of clinical and translational researchers who can quickly and… more
Abstract:Researchers are currently hindered when observing dynamic gas-solid interactions in the transmission electron microscope (TEM). Yet solid-state materials and gases interact in many important ways. The most critical technological application for these observations is catalysis, where one would like… more
Abstract:Understanding the microstructural origins of the mechanical behavior of materials has always been a core area of mechanical engineering and materials science. Renewed importance has been placed on mechanical behavior studies because the length scales of electronic and mechanical structures have… more
Abstract:The inability to dynamically image solid-state materials at atomic resolutions and perform spectroscopy at the same time in changing liquid and gas environments is a significant impediment to the advance of multiple areas of science. Recently Hummingbird Scientific has developed commercially viable… more
Abstract:The project will develop a cost-effective strategy for disposing of manure produced on dairy farms by developing an affordable anaerobic digestion method that requires lower infrastructure investment and operating costs. This will lead to less reliance on traditional energy sources for dairies and… more
Abstract:In the GMD battlespace, it"s critical to rapidly ascertain specific identifying characteristics of a track so follow-on sensors can match the same track. Currently, sensors communicate track data with differing biases and uncertainties with little data-rich content and attempts to utilize track… more
Abstract:Situation/threat modeling and threat prediction require higher levels of data fusion to provide actionable information to the warfighter. Beyond sensor data and sources the analyst has control over, the use of out-sourced and re-sourced data are becoming more common. However, the current data fusion… more
Abstract:Today"s intelligence exploitation has an information challengethere is a great deal of data being processed by a large number of analysts with insufficient ability to identify anomalies in the data. The process needs a capability that can facilitate a rapid understanding of complex information… more
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