Abstract:DESCRIPTION (provided by applicant): Endometriosis is a major cause of severe pelvic pain, pain during menstruation, dyspareunia and infertility in women of child-bearing age with an estimated 22 billion cost of diagnosis and treatment in the U.S. The disease ordinarily regresses after menopause… more
Abstract:DESCRIPTION (provided by applicant): Stiffness and alignment of ankle-foot orthoses (AFOs) are essential factors for its optimal function and fit. Improper stiffness and alignment of an AFO may induce joint pain, reduced ambulatory function, and increasedmedical complications for patients with… more
Abstract:DESCRIPTION (provided by applicant): The fit of a prosthesis determines the function of the user to a great degree. In the extreme, a painful fit will result in non-use of the prosthesis. Diurnal, menstrual and other fluctuations in body weight lead to noticeable changes in comfort and function of… more
Abstract:DESCRIPTION (provided by applicant): Current biomarkers employed in the detection of organ toxicity are often not sensitive enough to detect the early stages of acute organ damage, i.e. at a stage when reducing or eliminating exposure to a toxin could prevent progression of organ damage or a disease… more
Abstract:DESCRIPTION (provided by applicant): The purpose of the present SBIR Phase 1 feasibility study is to assess the efficacy of our selective dopamine (DA) transport inhibitor PD2005 in improving cognitive deficits associated with traumatic brain injury (TBI).Executive function deficits like short term… more
Abstract:DESCRIPTION (provided by applicant): PD2007 is a selective DAT inhibitor that P2D Bioscience (P2D) is developing for the treatment of obesity. PD2007 is an analog of benztropine (Cogentin) a non-Scheduled, safe FDA-approved drug in clinical use for over 40years. Structure-activity-relationship… more
Abstract:DESCRIPTION (provided by applicant): SBIR Phase 1 preclinical studies demonstrate the efficacy of our proprietary compound, PD2005, for treating Attention Deficit/Hyperactivity Disorder (ADHD). PD2005 is a selective dopamine (DA) transport inhibitor that P2D is developing for the treatment of… more
Abstract:This Phase I Small Business Innovative Research Program will develop and demonstrate the technology to produce large-scale, high temperature, lightweight composite missile structures for transition to a fielded weapons system where weight minimization and resistance to high temperature exposure is… more
Abstract:Three-dimensional textile preforms have shown tremendous advantages in the integration of load-bearing composite structures to traditional laminated composites and fastened structures due to improved delamination and damage tolerances. Hindrances occur when the composites are subjected to elevated… more
Abstract:In this Phase I Small Business Innovative Research Program we will develop and demonstrate novel materials and processes to provide improved Shipboard Radome performance for Air and Missile Defense Radar (AMDR) systems and operational assessment technologies to mitigate risk and impact of Radome… more
Abstract:This Phase II SBIR program will develop and demonstrate a high temperature polymer matrix composite system for use in a structural missile component in multiple BMD systems. Under this program, an extensive database of thermal, mechanical, and electrical properties will be established for the… more
Abstract:This Phase II Small Business Innovative Research Program will mature, and transition to the Air Force, a novel class of high performance structural adhesives based on P2SI newly developed hybrid chemistry. These adhesives, and their ability to bridge major technology gaps in the current… more
Abstract:The proposed Phase II innovation for a pitch fiber composite will make it possible to achieve the stated mechanical and thermal performance goals of the solicitation: 1) comparable mechanical performance to a state-of-the-art toughened epoxy/PAN carbon fiber composite; and 2) transverse thermal… more
Abstract:Tuna are among the most highly valued fish worldwide. Due to this value and high demand, tuna are being fished beyond sustainable levels in many parts of the world. Replacing or supplementing wild catch with hatchery raised tuna makes sense, but this is technically difficult with current technology.… more
Abstract:Unmanned vehicles (UVs) are transforming the submarines collection and communication capabilities. However, the user tasks needed to employ UVs are not seamlessly integrated into existing submarine tasks and personnel assignments. Further, submarines will have to flexibly coordinate UV employment… more
Abstract:The primary objective of this proposal is to develop a real-time decision support toolkit to provide mission planners a transparent method for using and interpreting empirical research findings. Such a tool would assist planners in making better educated decisions regarding how various environmental… more
Abstract:The Primed Intuition Training (Prime-IT) program combines cognitive and training science with critical domain knowledge, incorporating advances in immersive training and neurocognitive measurement, to develop the foundation for sound, intuitive decision-making. At the heart of Prime-IT are… more
Abstract:here is great current interest in improving the contact management of submarines operated in the littorals. Littoral contact management is challenging because the ambiguities inherent in contact localization make accurately reconstructing each contact a hard task. Littoral contact density is high,… more
Abstract:Modern warfare takes many forms. A common requirement across this spectrum of conflict is the need to understand and predict combatant and non-combatant goals and actions. OSD directs and oversees the Human Social Culture Behavior Modeling (HSCB) program to develop reliable, validated… more
Abstract:DESCRIPTION (provided by applicant): Loss of hearing affects the quality of life for individuals. The number of Americans with hearing loss is increasing as baby boomers age and younger citizens damage their hearing with personal audio devices. By 2025, approximately 40 million Americans are… more
Abstract:DESCRIPTION (provided by applicant): A Novel Regenerative Therapy for Myocardial Infarction Myocardial infarction (MI) is an acute public health problem killing one third of the 1.5 million Americans afflicted annually. Almost all MIs are caused by ruptureof coronary atherosclerotic plaques with… more
Abstract:DESCRIPTION (provided by applicant): Monobody for Renal Inflammation End stage renal disease (ESRD) affects gt485,000 Americans, including over 341,000 hemodialysis patients with an estimated 90,000 new cases per year. The annual cost of treating Americanssuffering from some form of kidney failure… more
Abstract:DESCRIPTION (provided by applicant): Susceptibility to common human diseases such as cancer and cardiovascular disease is determined by numerous genetic factors that interact in a nonlinear manner in the context of an individual's age and environmental exposure. This complex genetic… more
Abstract:The original Sublimator Driven Coldplate (SDC) design sought to provide significant mass savings over a traditional pumped fluid loop by combining the functions of a cold plate and a sublimator and eliminating the fluid loop (Leimkuehler, et. al., "Design of a Sublimator Driven Coldplate… more
Abstract:Extended duration missions to the Moon and Mars will require the use of In-situ resources to generate propellants and life support consumables. Many of the processes for in-situ resource utilization (ISRU) produce water, along with a variety of acid gases and other water soluble contaminants. … more
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