Abstract:DESCRIPTION (provided by applicant): Metabolism of administered drugs is determined by expression and activity of drug-metabolizing enzymes, such as cytochrome (CYP) P450 enzymes. These P450s are subject to inhibition and sometimes induction by xenobiotics, leading to possible pharmacokinetic… more
Abstract:We propose to fabricate a germanium blocked-impurity-band (BIB) detector using a novel process which will enable us to:1-fabricate a suitably-doped active layer using the well-established bulk crystal-growth process, which guarantees excellent dopant control and extremely low compensating impurities… more
Abstract:We propose to investigate the feasibility of developing a low noise, two-side buttable, 64x64 readout multiplexer with the following key design features:1- By far the largest readout array developed for far IR detectors to date. Four of these readout can be butted together to form a >16k-pixel… more
Abstract:DESCRIPTION (provided by applicant): This proposal seeks funding for a Phase I grant to develop tools for older Americans to use in assessing their financial needs and resources, including those related to health care. The Orlin Financial Planner will allow older Americans to access accurate,… more
Abstract:Electroplated hard chrome is used extensively for aerospace and industrial applications because it is wear resistant, corrosion resistant, has a good surface finish and has good adhesion. Naval aircraft use chrome plating on landing gear components because of these characteristics. However these… more
Abstract:Aging aircraft experience fatigue cracking from stress concentrations around rivet holes. Current best practice is to pull an oversized mandrel through the hole to induce beneficial residual compressive stresses and this improves fatigue life significantly. However, the benefit is reduced for… more
Abstract:Cold Spray is an emerging technology that uses pressurized gas to accelerate metal particles above a certain critical velocity so that they adhere to the targeted substrate and to each other. Liquid accelerated cold spray uses high pressure, high velocity liquid to accelerate the particles instead… more
Abstract:The overall goal of this Phase II project is to develop a prototype micro-fluidic sampling system that will lead to a field-deployable detection system capable of detecting low ppb levels of chemical warfare agents (CWAs) and explosive precursors in water. The proposed work will capitalize on Phase… more
Abstract:The goal of this Phase I project is to develop coatings for M8 paper that improve its robustness and rate of detection of potential liquid/aerosol chemical warfare attack at fixed military sites and installations. A problem that is currently experienced with M8 paper is that it is easily… more
Abstract:ABSTRACT: In this project, Orora Design Technologies, Inc. is teaming up with researchers from the University at Albany and the University of Washington to develop techniques to design, simulate and fabricate CMOS-memristor CMOL crossnet building blocks and neuromorphic processors. Phase I… more
Abstract:OBJECTIVE: The successful outcome of this effort will support the use of ultra-deep submicron integrated circuits in DoD satellite systems that will result in very significant savings in weight, power and reliability for systems that include Space Radar, Space Tracking and Surveillance Systems and… more
Abstract:DESCRIPTION (provided by applicant): Endometriosis is a major cause of severe pelvic pain, pain during menstruation, dyspareunia and infertility in women of child-bearing age with an estimated 22 billion cost of diagnosis and treatment in the U.S. The disease ordinarily regresses after menopause… more
Abstract:DESCRIPTION (provided by applicant): Stiffness and alignment of ankle-foot orthoses (AFOs) are essential factors for its optimal function and fit. Improper stiffness and alignment of an AFO may induce joint pain, reduced ambulatory function, and increasedmedical complications for patients with… more
Abstract:DESCRIPTION (provided by applicant): The fit of a prosthesis determines the function of the user to a great degree. In the extreme, a painful fit will result in non-use of the prosthesis. Diurnal, menstrual and other fluctuations in body weight lead to noticeable changes in comfort and function of… more
Abstract:DESCRIPTION (provided by applicant): Current biomarkers employed in the detection of organ toxicity are often not sensitive enough to detect the early stages of acute organ damage, i.e. at a stage when reducing or eliminating exposure to a toxin could prevent progression of organ damage or a disease… more
Abstract:DESCRIPTION (provided by applicant): The purpose of the present SBIR Phase 1 feasibility study is to assess the efficacy of our selective dopamine (DA) transport inhibitor PD2005 in improving cognitive deficits associated with traumatic brain injury (TBI).Executive function deficits like short term… more
Abstract:DESCRIPTION (provided by applicant): PD2007 is a selective DAT inhibitor that P2D Bioscience (P2D) is developing for the treatment of obesity. PD2007 is an analog of benztropine (Cogentin) a non-Scheduled, safe FDA-approved drug in clinical use for over 40years. Structure-activity-relationship… more
Abstract:DESCRIPTION (provided by applicant): SBIR Phase 1 preclinical studies demonstrate the efficacy of our proprietary compound, PD2005, for treating Attention Deficit/Hyperactivity Disorder (ADHD). PD2005 is a selective dopamine (DA) transport inhibitor that P2D is developing for the treatment of… more
Abstract:This Phase I Small Business Innovative Research Program will develop and demonstrate the technology to produce large-scale, high temperature, lightweight composite missile structures for transition to a fielded weapons system where weight minimization and resistance to high temperature exposure is… more
Abstract:Three-dimensional textile preforms have shown tremendous advantages in the integration of load-bearing composite structures to traditional laminated composites and fastened structures due to improved delamination and damage tolerances. Hindrances occur when the composites are subjected to elevated… more
Abstract:In this Phase I Small Business Innovative Research Program we will develop and demonstrate novel materials and processes to provide improved Shipboard Radome performance for Air and Missile Defense Radar (AMDR) systems and operational assessment technologies to mitigate risk and impact of Radome… more
Abstract:This Phase II SBIR program will develop and demonstrate a high temperature polymer matrix composite system for use in a structural missile component in multiple BMD systems. Under this program, an extensive database of thermal, mechanical, and electrical properties will be established for the… more
Abstract:This Phase II Small Business Innovative Research Program will mature, and transition to the Air Force, a novel class of high performance structural adhesives based on P2SI newly developed hybrid chemistry. These adhesives, and their ability to bridge major technology gaps in the current… more
Abstract:The proposed Phase II innovation for a pitch fiber composite will make it possible to achieve the stated mechanical and thermal performance goals of the solicitation: 1) comparable mechanical performance to a state-of-the-art toughened epoxy/PAN carbon fiber composite; and 2) transverse thermal… more
Abstract:Tuna are among the most highly valued fish worldwide. Due to this value and high demand, tuna are being fished beyond sustainable levels in many parts of the world. Replacing or supplementing wild catch with hatchery raised tuna makes sense, but this is technically difficult with current technology.… more
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