Abstract:Many of the antibodies produced for cancer research are poorly characterized, exhibit suboptimal affinity or selectivity, and are time-consuming and expensive to produce. Alternative affinity capture reagents are therefore needed as reproducible, highly characterized, rapid, and cost-effective… more
Abstract:DESCRIPTION (provided by applicant): With funding from NIMH, TeleSage has developed a state-of-the-art mental health outcomes tracking survey instrument for use with both public- and private-sector adults. This survey is currently in statewide use in Tenne
ssee and Iowa. Unfortunately, no… more
Abstract:DESCRIPTION (provided by applicant): Computer Adaptive Testing (CAT) provides a new mechanism for assessing patient-reported outcomes. Using CAT can: (a) increase measurement precision, leading to a decrease in the number of participants necessary to achieve statistically significant… more
Abstract:DESCRIPTION (provided by applicant): Rheumatoid Arthritis (RA) is a debilitating disease which affects nearly 1% of the US population. It initially attacks the small joints of the hand and foot. Recent RA research shows that early aggressive therapy is mos
t effective, making early diagnosis… more
Abstract:The proposed project is to manufacture a C-SiC honeycomb structure to use as a high temperature material in advanced aircraft, spacecraft and industrial applications. The proposers will fabricate a carbon fiber honeycomb structure. The structure will be charred and then converted to C-SiC by means… more
Abstract:DESCRIPTION (provided by applicant): In this Phase I application we will examine the feasibility of producing high yield porous nanocrystalline silicon (pnc-Si) membranes for protein purification products. Membranes made of this material are a breakthrough
technology, 1000x thinner than… more
Abstract:Performance of conventional primary and secondary batteries improve at a meager rate every year. Sensors and sensor networks which are advancing through relentless miniaturization effects need uninterrupted power sources in many scenarios. We propose to use a piezoelectric based energy scavenging… more
Abstract:ELORET Corporation, in collaboration with the Space Systems Design Laboratory of Georgia Institute of Technology, proposes developing and demonstrating a capability/technology to de-orbit small payloads (approximately 1 kg) from Low-Earth Orbit and returning them to Earth safely. To achieve this… more
Abstract:The proposed phase I research effort will develop a highly efficient MEMS energy harvesters that utilize a novel nanocomposite technology recently developed by Sodano Engineering LLC. Unlike existing piezoelectric nanocomposites, the material proposed here has an electromechanical coupling… more
Abstract:The proposed Phase I research effort will develop a novel technique to place vertically aligned ZnO nanowires in the interlaminar region of fiber reinforced composites. It is widely accepted that the interlaminar region of a composite presents one of the most challenging failure mechanisms to… more
Abstract:Oncology remains a major market of unmet need. BNOAT Oncology¿s long-term objective is New Drug Approval of its lead candidate nitrosylcobalamin, a tumor-specific, apoptosis-inducing, anti-cancer drug. Research Design and Methods: Nitrosylcobalamin purification will include… more
Abstract:Rapid tuning of narrowband sources is inherently limited by the number of roundtrips required in the high-Q cavity, which is required for generation of a narrow lasing linewidth. We propose to break the cavity tuning/linewidth barrier presented by conventional reconfiguration of the physical cavity… more
Abstract:Advanced airframes are expected to serve in multirole missions; mission-specific nodes must be incorporated in a scalable manner without performance penalty to existing services. Such systems are expected to operate with a mix of digital and analog signaling, with certain nodes likely requiring… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this SBIR proposal is to develop and commercialize a new approach for allergen specific immunotherapy as treatment for cat allergy. This proposal will provide a novel therapeutic for a very importan
t inhalant allergen and serve as a model… more
Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to develop and commercialize a novel approach for allergen specific immunotherapy as treatment for severe food allergy. Food allergy affects about 3.5% of the US population and 6% to 8% ofyoung children. It is clearly on the rise.… more
Abstract:Robust, lightweight, power-efficient excavation robots are mission
enablers for lunar outposts and surface systems. Lunar excavators of this
type cost-effectively utilize native materials for both outpost
preparation and in-situ resource utilization. They address the need for
implements that dig,… more
Abstract:The proposed innovation is a scalable gravity off-load system that enables controlled integrated testing of Surface System elements such as rovers, habitats, and space suits in planet-relevant gravity which addresses T6.02 in the direct solicitation of a gravity off-load system. Phase I delivers a… more
Abstract:DESCRIPTION (provided by applicant): Recently methicillin resistant Staphylococcus aureus (MRSA) has surpased HIV as the most deadly pathogen in the United States, accounting for over 100,000 deaths per year. In Orthopaedics, MRSA osteomyelitis (OM) has b
ecome the greatest concern in patient care,… more
Abstract:DESCRIPTION (provided by applicant): This Phase I SBIR application entitled Substance Abuse Continuing Care through Mobile Assessment and Messaging is designed to create a low cost, continuous care decision support text messaging intervention to increase
treatment adherence, decrease drop-out and… more
Abstract:DESCRIPTION (provided by applicant): Flow cytometry is a bioanalysis technique that enables counting and sorting of cells and particles based on their physical and biochemical properties. Flow cytometer instruments are widely used in diverse research and c
linical settings, for example the diagnosis… more
Abstract:DESCRIPTION (provided by applicant): Ion channels are membrane proteins that allow the selective movement of charged molecules through cellular membranes. Many disease states, such as cystic fibrosis, muscular dystrophies, hypertension, and cardiac arrhyth
mias are caused by ion channel pathologies.… more
Abstract:DESCRIPTION (provided by applicant): Retinitis Pigmentosa (RP) is an inherited disease of the eye that robs its victims of vision. The loss of vision is caused by the degeneration of the rods and cones of the retina while other cells in the retina remain
alive. RD is a relatively rare disease,… more
Abstract:DESCRIPTION (provided by applicant): Seasonal Affective Disorder (SAD) is one of the most common mood disorders, affecting 1-3% of the population in temperate climates, predominantly women. Currently, there are no specific drug therapies for SAD. Patients
are prescribed general anti-depressants or… more
Abstract:DESCRIPTION (provided by applicant): The SACC-Substance Addiction Collaboration Channel(R) platform is a new Collaboration, WEB-2.0 springboard specifically designed to structure and share information across the Behavioral/Mental Health Workforce commun
ity with the special focus on… more
Abstract:DESCRIPTION (provided by applicant): Abnormalities in the cytosol of subpopulations of cells are often a hallmark of pathology. Most analysis methods will only provide information on the cytosol of cell populations as a whole, not for individual cells or s
ubpopulations of cells. To overcome this,… more
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