Abstract:DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. The currently available treatments are largely palliative and have minimal impact on the inflammatory proce
ss in COPD that inexorably leads to a… more
Abstract:DESCRIPTION (provided by applicant): Despite notable achievements over the past two decades, cancer remains a challenging 21st century epidemic demanding new, more effective drugs. Nitric oxide (NO) is well known to kill cancer cells without harming norma
l bone marrow cells, but until now has not… more
Abstract:DESCRIPTION (provided by applicant): Ohmx Corporation is developing integrated point-of-care (POC) bioelectronic sensor technologies for protein biomarkers relevant to cancer diagnosis and risk stratification. The principal goal of this SBIR proposal is to
develop an assay for prostate-specific… more
Abstract:DESCRIPTION (provided by applicant): Loss of ambulatory function due to disease and injury has an increasing societal impact as the US population ages and has an even greater impact on veterans. The development of methods for effective assessment and reha
bilitation of impairments of the ambulatory… more
Abstract:DESCRIPTION (provided by applicant): There is a strong need for the development and dissemination of effective prevention programs for mental health problems with college students, who are at risk for depression, anxiety, eating disorders, substance use, a
nd many other difficulties (American… more
Abstract:This proposal by Jansen's Aircraft Systems Controls, Inc presents an innovative solution for Active Combustion Control. Relative to the state of the art, this concept has the ability to provide frequency modulation (greater than 1000 Hz) in combination with high amplitude modulation (in excess of… more
Abstract:The proposed innovation is to apply proven nano-film technology to enable Microchannel plate (MCP) devices to be manufactured on a range of insulating substrates and devices which possess sufficiently high gain and low ion feedback to replace chevron stacks in current NASA detector technologies. … more
Abstract:The work proposed in this SBIR proposal is intended to follow the basic R&D effort of a consortium of national laboratories, universities, and industry, led by Argonne National Laboratory and the University of Chicago for the development of new, large area, photo-detector devices. This project… more
Abstract:DESCRIPTION (provided by applicant): 5-Aminosalicylic acid (5-ASA) and its analogs such as the prodrug sulfasalazine are front line therapy for Inflammatory Bowel Disease (IBD), which include both Crohn's disease and ulcerative colitis. 5-ASA is only moder
ately efficacious in putting patients into… more
Abstract:DESCRIPTION (provided by applicant): Measurements of the affinity, potency and efficacy of ligands to G protein-coupled receptors (GPCRs) are fundamental to pharmacology and drug discovery. Cellular functional assays measuring the production of GPCR second
messengers such as cAMP and inositol… more
Abstract:DESCRIPTION (provided by applicant): With increasing risk of nuclear detonation there is a need for effective medicinal counter-measures that can be delivered after exposure to prevent radiation-induced mortality. Adding to this need, mortality increases s
ignificantly when radiation is combined… more
Abstract:* * Description of team not provided in the application aside from CVs thus making it difficult to assess quality. 3. Innovation: Strengths * Development of inexpensive, simple, disposable, point-of-care screening method attractive. * A
ntigen-modified detector is unique. *… more
Abstract:DESCRIPTION (provided by applicant): For such life-changing impact that bariatric surgery represents for obesity, this popular procedure is noted for its poor post- operative follow-up rates and outcomes tracking. Laparoscopic Gastric Bypass (LGB) has emer
ged as one of the most popular surgical… more
Abstract:DESCRIPTION (provided by applicant): Bone fractures are common traumatic injuries that often cause temporary disability. In healthy children and adults, fractures normally heal without sequelae, though the temporary disability can lead to muscle atrophy,
rehabilitation, and lost time from the work… more
Abstract:DESCRIPTION (provided by applicant): This Fast-Track SBIR proposal submitted by SoloHealth of Duluth, Georgia, requests grant funds to build and test a multifunction health-screening kiosk. Our current kiosk prototype, EyeSite, has demonstrated efficacy in
reaching low income, high health disparity… more
Abstract:DESCRIPTION (provided by applicant): High-fidelity clinical movement analysis with body mounted sensors Summary Clinical movement analysis is an important tool for management of orthopedic and neurological movement disorders. Despite scientific and clinic
al successes, this tool has not found… more
Abstract:DESCRIPTION (provided by applicant): Reducing Health Disparities: A Health IT Solution, proposes a collaborative effort to coordinate community stakeholders in Dane County, WI, to integrate a replicable and innovative health IT solution to overcome syste
mic barriers that exacerbate health… more
Abstract:When the United States military commits to operations in foreign territories, it is important for soldiers to have the ability to understand textual information they encounter accurately and in a timely manner. For this SBIR Limaging proposes to develop a document and sign translation system that… more
Abstract:Objects tracked by optical sensors in ascent phase and midcourse are frequently obscured on the focal plane by countermeasures and debris (or clutter) that affect the performance of discrimination and tracking algorithms. Ascent phase can be especially challenging due to the presence of fuel… more
Abstract:The objective of this proposal is to develop a Multiple Hypothesis Tracking (MHT) algorithm that will operate in real-time while receiving detection reports in ascent phase from a variety of disparate sensors. ExoAnalytic Solutions has developed mature tools, including the CCIR3 CSO algorithm and… more
Recent National Assessment of Educational Progress reports indicate that high percentages of students – especially English Language Learners, those with reading deficiencies, and those with… more
Recent National Assessment of Educational Progress reports indicate that high percentages of students – especially English Language Learners, those with reading deficiencies, and those with learning… more
Abstract:Atomic Layer Deposition (ALD) has been widely studied for water permeation barriers for flexible OLED displays. Inorganic films of approximately 100nm have been demonstrated to reduce the water vapor transmission rate (WVTR) to 6e-7 g/m^2/d at room temperature. However, these films crack at less… more
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