Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to create immunotherapeutics based on two high-affinity, HIV-specific, soluble T cell receptors (TCRs) as targeting molecules for HIV-infected cells. These human-derived TCRs were selected b
ased on their ability to recognize HIV… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this proposal is to develop tumor-targeted TCR-IL15 fusion proteins as immunotherapeutics for treating cancers. Previous proof-of-concept studies with TCR-IL2 and TCR-IgG1 fusion proteins in m
ouse tumor efficacy models demonstrated the… more
Abstract:The Ballistic Missile Defense System (BMDS) requires a method for a distributed, near real-time, security management system that provides comprehensive situational awareness of the Information Assurance state of the BMDS and its components. Altusys has de
Abstract:AM Biotechnologies (AM) will develop a diagnostic system in response to SBIR Topic X10.01 Reusable Diagnostic Lab Technology that will simultaneously detect and quantify numerous protein biomarkers with excellent sensitivity. AM will enhance the current clinical gold standard immunoassay… more
Abstract:DESCRIPTION (provided by applicant): Systemic Anaplastic Large Cell Lymphoma (ALCL) is the most common T-cell lymphoma in children. ALCL is characterized by its anaplastic cell morphology and high level expression of CD30 on the cell surface. This diffuse
and homogeneous CD30 expression in ALCL… more
Abstract:In response to OSD/NAVY's need for landing gear component applications, We propose to develop advanced high strength steels using CDC compaction manufacturing. Common materials used are 4340 steel, 300M, and AerMet 100. AerMet 100 has superior material properties to 4340 and 300M. Landing gear… more
Abstract:In response to MDA's needs for non-eroding throats for controllable axial upper stages , UTRON proposes an innovative near net shape fabrication technology called High Pressure Combustion Driven Powder Compaction (CDC) with tremendous potential for cost-effective manufacturing of advanced cermet… more
Abstract:This Small Business Innovation Research Phase I research project will use femtosecond laser machining to fabricate Lithium ion based nanobatteries composed of arrays of nanocells. In addition, an array of addressable batteries will also be constructed. A femtosecond laser is a powerful tool to… more
Abstract:DESCRIPTION (provided by applicant): There is an urgent need to develop an effective method for detection of primary and recurrent bladder cancer. Bladder cancer is the fourth most common malignancy in men and the ninth most common malignancy in women in W
estern countries. If identified early,… more
Abstract:DESCRIPTION (provided by applicant): A key rationale of this project is the growing need for an improved low-cost, high sensitivity multigene mutation profiling method for tumors. An important example is the recent recommendation of the National Comprehens
ive Cancer Network (NCCN) to screen all… more
Abstract:A dc-dc converter with integrated Magnetics and sensor and ZVS, ZCS circuit topology in one package to reduce the interconnects and the losses is proposed. The custom made three dimensional magnetic design will allow us to increase the switching frequency to >500kHz, while maintaining >92%… more
Abstract:A network of the Distributed exportable power Generation "DG" with each DG capable of having local power and energy management. The main power and energy control is based on the real time power generation and the reserve capacity of the DG unit. All DG units communicate via CAN J1939 with local and… more
Abstract:DESCRIPTION (provided by applicant): Fragile X Syndrome (FXS), is the most common form of inherited mental retardation, affecting 1 in 4000 males and about 1 in 6000 females of all ethnicities. Additionally, carrier frequencies are quite high. About 1 in
250 females carry Fragile X and about 1 in… more
Abstract:DESCRIPTION (provided by applicant): The overall objective for this project is to develop and implement a comprehensive set of technologies to improve screening and diagnosis of conditions associated with Fragile X Syndrome (FXS). FXS is caused by an expa
nsion of a cytosine-guanine-guanine (CGG)… more
Abstract:DESCRIPTION (provided by applicant): Malignant melanoma is the least frequent but the most aggressive and deadliest form of skin cancer. Early detection and accurate staging are therefore crucial to ensure timely intervention and a good prognosis. Our long
-term goal is to develop a microRNA (miRNA)… more
Abstract:DESCRIPTION (provided by applicant): In the United States, lung cancer has the highest incidence and the highest mortality rate of all cancers. An estimated 215,020 new cases of lung cancer and an estimated 161,840 deaths from lung cancer will occur in the
United States during 2008. This high… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is to develop a comprehensive molecular diagnostic assay for the detection of clinically relevant genetic abnormalities in patients with acute myeloid leukemia (AML), chronic myel
ogenous leukemia (CML), and… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop and implement an integrated suite of technologies for enabling microarray-based diagnostic assays and the cGMP manufacturing processes and procedures necessary to manufact
ure these products. Microarrays have found… more
Abstract:The US Ferroics / Colorado State University team proposes to utilize it''s mature expertise gained in materials deposition and characterization at RF / microwave frequencies to investigate a series of low-loss electrode / metalization technologies for hetero-ferroic RF devices. The first component… more
Abstract:This proposal investigates the concept of swift trust in temporary teams. We will investigate cognitive and behavioral manifestations of trust and propose metrics to measure the formation of swift trust. Further, we propose to research and develop a training program for leaders which will help… more
Abstract:The objective of this Phase 2 Program is to build on the Phase 1 results: 1). Continue refine the millimeter wave HIFET model. 2). Fabricate and test GaN HEMT millimeter wave HIFET to prove the validity of the millimeter wave HIFET model. 3). Develop State-of-the-art millimeter wave MMIC PA module… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to solve the computational problem of on-demand job matching and scheduling for the purpose of creating an active online listing in the service domain. The recent explosion of online listings reflects the demand by users for… more
Abstract:The Army needs a suite of effective Modeling, Analysis, Simulation, and Evaluation tools for the design, development, implementation and validation of the gyrocompassing based azimuth and attitude determination modules for the FTL systems. The Phase II project is to demonstrate, test, validate, and… more
Abstract:The objective of this project is to demonstrate intelligent health and maintenance status determination and predictive fault diagnosis techniques for NASA rocket engines under online and offline conditions from either on-board or maintenance, test and analytic data. AGNC proposes a Health and… more
Abstract:The on-ground and Distributed Rocket Engine Testing Health Monitoring System (DiRETHMS) provides a system architecture and software tools for performing diagnostics and prognostics for supporting NASA's Integrated System Health Management (ISHM) capability for rocket engine testing and ground… more
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