Abstract:DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). The abnormal accumulation of neurotoxic brain ss-amyloid peptides (A?) is thought to be a possible cause the disease. A? are p
roduced by proteolytic cleavage of a larger… more
Abstract:DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). Neurotoxic ?-amyloid peptides (A??) are thought to cause the disease with their accumulation in brain plaques being a hallmar
k. A? are cleaved from a larger amyloid… more
Abstract:Research reactors such as the High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL) and the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) have a long history of service to the nation and are expected to continue to operate successfully for many more years.… more
Abstract:Power generation utilities are striving to use wireless technologies in nuclear power plants, but a number of important challenges must be overcome. These challenges include infrastructure issues, security risks, reliability questions, and interference problems. This project will develop a… more
Abstract:Analysis, Design & Diagnostics, Inc. has put together a unique team comprised of the Woods Hole Oceanographic Institution, Adaptive Methods, Inc. and Teledyne Benthos. Under this effort the team will develop a planning tool designed so that environmental and operational mission planners can… more
Abstract:A 4-channel marine mammal detection and classification system capable of automatically detecting and classifying marine mammal vocalizations will be developed under this Phase II effort. The system will allow the operator to view marine mammal vocalizations throughout the spectrum and will include… more
Abstract:During the past century, physicists have explored subatomic particles in an attempt to understand the fundamental components of the universe, explain the origin of mass, and probe the possibility of an extra-dimensional universe. To advance these explorations, scientists from around the world are… more
Abstract:DESCRIPTION (provided by applicant): Despite significant recent government and private-sector efforts to improve the current state of the art in bone marrow transplants, many patients still suffer from lack of adequate matching bone marrow inventories and
from severe treatment-related complications… more
Abstract:In the proposed SBIR Phase I project, American Superconductor Corporation (AMSC) will carry out an extensive industry "best practice" exercise to optimize a high temperature superconductor (HTS) degaussing cable design to meet U. S. Navy (USN) shock and vibration requirements. The materials… more
Abstract:Analytical Services, Incorporated, teamed with Davidson Technologies, proposes a new approach to the characterization of drag and lift coefficient distributions for debris resulting from missile intercepts. The proposed approach utilizes both theoretical considerations and available measured data… more
Abstract:In this SBIR project, a preliminary design of a highly accurate, highly repeatable impulse thruster will be completed. ASI, together with ATK, proposes to complete the preliminary design in parallel with the development of a comprehensive thruster model in a Monte Carlo environment that will… more
Abstract:Jet engine titanium compressor airfoils are susceptible to erosion damage ranging from a few percent loss in blade chord length in fighter engines to more significant erosion exhibited by helicopter engines operating in desert environments. The application of titanium nitride coatings on individual… more
Abstract:The majority of students and educators would probably agree that students are better able to grasp scientific concepts from the use of hands-on activities and other inquiry-based educational practices than from typical lecture problem solving methods. Anasphere, Inc is working to make
inquiry based… more
Abstract:Improved observations of the battlespace are of key and growing importance in today's combat environment. UAVs are making key contributions in this area, and sensor improvements are a key part of increasing UAV capabilities. However, all sensors are subject to degradation under detrimental… more
Abstract:Phase 1 has seen the development of a revolutionary new type of sensor for making carbon dioxide (CO2) measurements from small Unmanned Aircraft Systems (UAS) and other platforms such as sounding balloons. The chemistry behind the new sensor has been proven, example sensors were fabricated, and the… more
Abstract:Scanning Probe Microscopy, SPM, is a strategically vital tool for nanotechnology research, a 250 million dollars per year industry essential to such multibillion-dollar downstream industries as materials and pharmaceuticals. However, the single biggest drawback to SPM is its inability to obtain any… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project seeks to develop the prototype of a characterization system which can perform IR spectroscopy and imaging at sub-100nm spatial resolution and thus break the 5 micron resolution barrier that has limited IR spectroscopy for the last 50… more
Abstract:The Anautics CourseBook Project will address three national critical issues in mathematics education the need to support standards based instruction, the need to raise student achievement scores through effective teaching, the need for instruction management through electronic curriculum guidance,… more
Abstract:The Global War on Terrorism is increasing pressure for DOD depots to expedite the return of serviceable weapon systems to the warfighter while maintaining or decreasing maintenance costs. Each military service has responded to this challenge by undertaking enterprise-wide logistics modernization… more
Abstract:Many Department of Defense (DoD) weapon systems are operating beyond their original design specifications, resulting in failures requiring unplanned parts, materials and sustainment procedures. Such U.S. Air Force weapon systems are collectively denoted as aging aircraft. A large number of aging… more
Abstract:DESCRIPTION (provided by applicant): Site-specific protein phosphorylation is essential for signal transduction in mammalian cells, and perturbation in phosphoprotein levels is a hallmark of cancerous transformation. Unfortunately there are no sensitive me
thods for detecting multiple… more
Abstract:"Situation or Problem" Immersion frying is a popular food preparation method. U.S. Consumers enjoy billions of pounds of low cost and taste appealing fried foods annually. Sensorial properties include golden color, crunchy crust, tender-moist core, and pleasing flavors. Unfortunately,… more
Abstract:DESCRIPTION (provided by applicant): The aim of the work proposed here is to demonstrate the feasibility Encouraging Handwashing Messages (EHM). The intent of EHM is to increase hand hygiene on a hospital floor by rewarding good hand hygiene with a voice m
essage praising the listener. In Phase I,… more
Abstract:Andrews Space proposes an inflatable rigidizable wing that can be stored folded or rolled up, and deployed at altitude via an inflation system, and will then cure to form a rigid wing improving the reliability and reducing the risk of an inflatable wing. It will also be much lighter and have a much… more
Abstract:The problem of debris propagation and impact location has been studied since the formation of the Missile Defense Agency because accurate prediction of where and with what probability the fragments created during an intercept will impact the ground is crucial to the determination of possible… more
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