Abstract:DESCRIPTION (provided by applicant): During Phase I of our proposed research, we will develop and validate procedures for recovering, labeling, and analyzing miRNAs from fixed tissue samples. The procedures will be based on the miRNA microarray and fix
ed tissue RNA isolation systems that we… more
Abstract:DESCRIPTION (provided by applicant): Prostate cancer (PrCa) is the most commonly diagnosed cancer in American men, with over 218,000 new cases diagnosed each year. It is second only to lung cancer in cancer mortality among men, and approximately 1 man in 5
will be diagnosed during his lifetime.… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop and implement an integrated suite of technologies for enabling microarray-based diagnostic assays and the cGMP manufacturing processes and procedures necessary to manufact
ure these products. Microarrays have found… more
Abstract:DESCRIPTION (provided by applicant): This is a proposal to develop a cGMP-manufactured RNA labeling kit suitable for clinical diagnostic assays and research applications that require multiplex RNA detection. The kit's target preparation technology will en
able accurate and reproducible profiling of… more
Abstract:The Small Business Innovation Research (SBIR) Phase I project proposes to achieve recently reported gains in CIGS solar cell efficiency from in-situ laser deposition, by using an ex-situ laser annealing approach that is compatible with an existing pilot manufacturing system. The proposed ex-situ… more
Abstract:With the increased high interest of the U.S. Air Force in developing the decision assistance tools that can optimize, layer, network, and allow cooperation of the distributed airborne sensors in the space domain and its operations, there is a fundamental need for increased level of automation,… more
Abstract:NASA is seeking innovative spatial and visual methods for search analysis and display of scientific data, to aid outreaching of this data to the interested mass-users. To address this need, AGNC proposes to develop innovative Attribute Image Map Fused 3D Web-Objects (AIMFO-3DWO) technology and… more
Abstract:Our long-term objective of this project is to develop an integrated system that is capable of categorizing and managing injured combatants in the field of combat trauma care. In this STTR, however, we focus on developing suitable imaging systems that can triage the combatants who are salvageable,… more
Abstract:This SBIR Phase II project aims to develop a commercial grade optical probe and system for FDA clinical trials and subsequent commercialization of a population-wide colon cancer screening test. An interdisciplinary research team of engineers, biologists, and clinicians has developed low-coherence… more
Abstract:Project Summary/Description The goal of this small business technology transfer application is to validate and commercialize an improved means of polyp detection during colonoscopy: spectroscopic microvascular blood assessment from the endoscopically norma
l mucosa. Missed lesions on colonoscopy are… more
Abstract:A new system is required aboard U.S. Army helicopters to assist the pilot in the landing of the aircraft in brown out or white out conditions. The brown out condition occurs when a helicopter attempts to land in a sandy environment and the downwash from the rotor kicks up the sand, engulfing the… more
Abstract:DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). The abnormal accumulation of neurotoxic brain ss-amyloid peptides (A?) is thought to be a possible cause the disease. A? are p
roduced by proteolytic cleavage of a larger… more
Abstract:DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). Neurotoxic ?-amyloid peptides (A??) are thought to cause the disease with their accumulation in brain plaques being a hallmar
k. A? are cleaved from a larger amyloid… more
Abstract:Research reactors such as the High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL) and the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) have a long history of service to the nation and are expected to continue to operate successfully for many more years.… more
Abstract:Power generation utilities are striving to use wireless technologies in nuclear power plants, but a number of important challenges must be overcome. These challenges include infrastructure issues, security risks, reliability questions, and interference problems. This project will develop a… more
Abstract:Analysis, Design & Diagnostics, Inc. has put together a unique team comprised of the Woods Hole Oceanographic Institution, Adaptive Methods, Inc. and Teledyne Benthos. Under this effort the team will develop a planning tool designed so that environmental and operational mission planners can… more
Abstract:A 4-channel marine mammal detection and classification system capable of automatically detecting and classifying marine mammal vocalizations will be developed under this Phase II effort. The system will allow the operator to view marine mammal vocalizations throughout the spectrum and will include… more
Abstract:During the past century, physicists have explored subatomic particles in an attempt to understand the fundamental components of the universe, explain the origin of mass, and probe the possibility of an extra-dimensional universe. To advance these explorations, scientists from around the world are… more
Abstract:DESCRIPTION (provided by applicant): Despite significant recent government and private-sector efforts to improve the current state of the art in bone marrow transplants, many patients still suffer from lack of adequate matching bone marrow inventories and
from severe treatment-related complications… more
Abstract:In the proposed SBIR Phase I project, American Superconductor Corporation (AMSC) will carry out an extensive industry "best practice" exercise to optimize a high temperature superconductor (HTS) degaussing cable design to meet U. S. Navy (USN) shock and vibration requirements. The materials… more
Abstract:Analytical Services, Incorporated, teamed with Davidson Technologies, proposes a new approach to the characterization of drag and lift coefficient distributions for debris resulting from missile intercepts. The proposed approach utilizes both theoretical considerations and available measured data… more
Abstract:In this SBIR project, a preliminary design of a highly accurate, highly repeatable impulse thruster will be completed. ASI, together with ATK, proposes to complete the preliminary design in parallel with the development of a comprehensive thruster model in a Monte Carlo environment that will… more
Abstract:Jet engine titanium compressor airfoils are susceptible to erosion damage ranging from a few percent loss in blade chord length in fighter engines to more significant erosion exhibited by helicopter engines operating in desert environments. The application of titanium nitride coatings on individual… more
Abstract:The majority of students and educators would probably agree that students are better able to grasp scientific concepts from the use of hands-on activities and other inquiry-based educational practices than from typical lecture problem solving methods. Anasphere, Inc is working to make
inquiry based… more
Abstract:Improved observations of the battlespace are of key and growing importance in today's combat environment. UAVs are making key contributions in this area, and sensor improvements are a key part of increasing UAV capabilities. However, all sensors are subject to degradation under detrimental… more
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