Abstract:Biofuels plant production is constrained by the high cost of moving agricultural residues from the farm to a central processing plant. Conventional equipment for biomass densification is too costly for use in upgrading feedstocks for biofuels plants. This project will develop an innovative biomass… more
Abstract:The objective of the research is to produce a technology that will effectively automate the processes of recognizing security threats to BMDS under the conditions of unpredictable dynamic situations and the periods of heightened alerts. Our method will provide human operators with results in the… more
Abstract:The goal of this effort is to develop technologies enabling situational awareness for large-scale cyber network defense, assessing the impact of adversarial action against a network, and predicting future adversary attack strategy. Based on Phase I, we plan to develop, implement, and validate a… more
Abstract:DESCRIPTION (provided by applicant): The siRNA molecule needs better protection from nuclease degradation before it can be effectively used as a therapeutic. AM Biotechnologies (AM) will address this critical issue by developing ribonucleoside thiophospho
ramidite (ABz, CBz, GIbu and U) reagents… more
Abstract:High energy physics accelerators and instruments in other fields require the use of thousands of superconducting radio frequency (SRF) cavities that are made of high purity niobium (Nb) material. The purity of Nb is critical for these cavities to reach the highest accelerating fields. Tantalum (Ta)… more
Abstract:This Small Business Innovation Research (SBIR) Phase I This Small Business Technology Transfer (STTR) Phase I project is aimed at developing a multi-objective bi-level approach to highway alignment optimization. Unlike the rapid developments in the automobile and construction industries road design… more
Abstract:The proposed Phase II STTR program will implement forward-error correction and other processing, as well as coherent transceiver operation, in order to improve the performance of underwater communications systems. Significant reduction in the bit-error rate will be demonstrated under both… more
Abstract:DESCRIPTION (provided by applicant): Significant advances have been made toward the development of a new generation of molecularly targeted cancer drugs, many of which are only now emerging from the pipeline. This project aims to develop a new, highly sens
itive technology for detecting… more
Abstract:Visual Data Mining (VDM) is an Internet-based software that supports spatial and temporal analyses of multimodal NASA science data including satellite images and in-situ sensory data. It combines computer vision, multi-physics simulation and interactive visualization. VDM tools can be integrated to… more
Abstract:DESCRIPTION (provided by applicant): Lymph node evaluation is an important prognostic factor in colorectal cancer (CRC) because accurate identification of lymph node metastases significantly influences survival. However, a 30% recurrence rate in patients w
ith node-negative CRC clearly indicates… more
Abstract:DESCRIPTION (provided by applicant): During Phase I of our proposed research, we will develop and validate procedures for recovering, labeling, and analyzing miRNAs from fixed tissue samples. The procedures will be based on the miRNA microarray and fix
ed tissue RNA isolation systems that we… more
Abstract:DESCRIPTION (provided by applicant): Prostate cancer (PrCa) is the most commonly diagnosed cancer in American men, with over 218,000 new cases diagnosed each year. It is second only to lung cancer in cancer mortality among men, and approximately 1 man in 5
will be diagnosed during his lifetime.… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop and implement an integrated suite of technologies for enabling microarray-based diagnostic assays and the cGMP manufacturing processes and procedures necessary to manufact
ure these products. Microarrays have found… more
Abstract:DESCRIPTION (provided by applicant): This is a proposal to develop a cGMP-manufactured RNA labeling kit suitable for clinical diagnostic assays and research applications that require multiplex RNA detection. The kit's target preparation technology will en
able accurate and reproducible profiling of… more
Abstract:The Small Business Innovation Research (SBIR) Phase I project proposes to achieve recently reported gains in CIGS solar cell efficiency from in-situ laser deposition, by using an ex-situ laser annealing approach that is compatible with an existing pilot manufacturing system. The proposed ex-situ… more
Abstract:With the increased high interest of the U.S. Air Force in developing the decision assistance tools that can optimize, layer, network, and allow cooperation of the distributed airborne sensors in the space domain and its operations, there is a fundamental need for increased level of automation,… more
Abstract:NASA is seeking innovative spatial and visual methods for search analysis and display of scientific data, to aid outreaching of this data to the interested mass-users. To address this need, AGNC proposes to develop innovative Attribute Image Map Fused 3D Web-Objects (AIMFO-3DWO) technology and… more
Abstract:Our long-term objective of this project is to develop an integrated system that is capable of categorizing and managing injured combatants in the field of combat trauma care. In this STTR, however, we focus on developing suitable imaging systems that can triage the combatants who are salvageable,… more
Abstract:This SBIR Phase II project aims to develop a commercial grade optical probe and system for FDA clinical trials and subsequent commercialization of a population-wide colon cancer screening test. An interdisciplinary research team of engineers, biologists, and clinicians has developed low-coherence… more
Abstract:Project Summary/Description The goal of this small business technology transfer application is to validate and commercialize an improved means of polyp detection during colonoscopy: spectroscopic microvascular blood assessment from the endoscopically norma
l mucosa. Missed lesions on colonoscopy are… more
Abstract:A new system is required aboard U.S. Army helicopters to assist the pilot in the landing of the aircraft in brown out or white out conditions. The brown out condition occurs when a helicopter attempts to land in a sandy environment and the downwash from the rotor kicks up the sand, engulfing the… more
Abstract:DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). The abnormal accumulation of neurotoxic brain ss-amyloid peptides (A?) is thought to be a possible cause the disease. A? are p
roduced by proteolytic cleavage of a larger… more
Abstract:DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). Neurotoxic ?-amyloid peptides (A??) are thought to cause the disease with their accumulation in brain plaques being a hallmar
k. A? are cleaved from a larger amyloid… more
Abstract:Research reactors such as the High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL) and the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) have a long history of service to the nation and are expected to continue to operate successfully for many more years.… more
Abstract:Power generation utilities are striving to use wireless technologies in nuclear power plants, but a number of important challenges must be overcome. These challenges include infrastructure issues, security risks, reliability questions, and interference problems. This project will develop a… more
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