Abstract:The feasibility of ANP's proposed seld-calibrated rapid test forf AChE inhibitors has been clearly shown in Phase I. Its compatability with ANP's handheld reader for immuno-assay based threat agent rapid testing has been confirmed. Phase II will finalize the design for robustness, full integration… more
Abstract:This Small Business Innovation Research Phase I project is directed towards development of an innovative technology for fabrication of high-efficiency thin film nanocomposite photovoltaic materials and solar cells taking advantage of the recently discovered breakthrough effect of carrier… more
Abstract:This project develops a multi modal computer interface device and authoring toolkit for the development of age appropriate computer learning for children and adolescents with developmental delays.
Abstract:One of the major questions simulation designers must address is "which components of fidelity have the greatest impact on transfer of training?" In theory, the notion is that the higher the simulation fidelity, the more likely an operator is to behave in a similar fashion within the simulation as… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase II project is to develop robot-based content to target upper extremity movement therapy goals and evaluate the clinical efficacy of the CosmoBot Robotics System as a therapy
intervention for children diagnosed with… more
Abstract:DESCRIPTION (provided by applicant): The goal of this application is to develop imageable tumor-targeting bacteria that can cure tumors without progressive infection of the host. Previous experiments by others employed anaerobic microorganisms for cancer t
herapy. Target specificity appeared largely… more
Abstract:This effort will identify and model the critical functional/physical system and subsystem requirements, components, subcomponents, and key performance parameters for a shock response spectrum test facility that is capable of multi-axis fuze testing.
Abstract:This proposal defines a pathway to safely carry and dispense gasoline and other highly volatile fuels within enclosed spaces aboard U.S. Navy ships, and in particular, the Littoral Combat Ship. This is necessary to accommodate the Combat Rubber Raiding Craft (CRRC) employed by SEAL detachments and… more
Abstract:We will build a versatile, compact, rugged and low-power laser system for use in rubidium Bose-Einstein condensate (BEC) experimentation and sensors. Existing commercial laser systems available for driving 780 nm rubidium transitions have very limited numbers of optical frequency outputs. … more
Abstract:DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection is a major cause of liver disease throughout the world. Existing therapies are suboptimal and the search for alternative therapies is imperative. Recent years have seen a tremendous inc
rease in efforts to identify more effective… more
Abstract:DESCRIPTION (provided by applicant): A novel bioprocess platform, involving synthesis of peptide and protein biopharmaceutical products as fusions with a synthetic anchor protein in bacteria, and subsequent proteolytic cleavage, will be developed. The un
ique features of the system allow for the… more
Abstract:Many NASA space and Earth programs in the infrared range 1060-1550 nm are limited by the detector performance that require long exposure time due to their low sensitivity and/or high noise. Large format infrared photon counting arrays with ranging capability would provide a valuable tool to many… more
Abstract:Long range, RF space communications do not meet anymore the bandwidth requirements or power constraints of future NASA missions. Optical communications offer the potential to dramatically increase the link bandwidth and decrease the emitter power. High-bandwidth, long-range optical communications… more
Abstract:The unique requirements of the high-voltage capacitive load DC/DC converter for the Navy's non-explosive based acoustic source provide an exciting opportunity for applying innovative design concepts not commonly encountered in commercial power supply product design. The objective of this SBIR… more
Abstract:To meet the ever-increasing power demand of today's spacecraft systems, an integrated power electronics system capable of interfacing, and simultaneously controlling, three power ports will be designed and demonstrated in Phase I of the proposed project. This new proposed power electronic… more
Abstract:DESCRIPTION (provided by applicant): This is an SBIR Phase II proposal directed at the continued development of a diagnostic for the early detection of age-related macular degeneration (AMD). It relies on a functional test of dark adaptation kinetics (the
transition from being light-adapted to… more
Abstract:DESCRIPTION (provided by applicant): This STTR Phase I proposal is directed at the development of a topical treatment for mild psoriasis. It is based on the recent discovery of a cell signaling module important for the regulation of keratinocyte proliferat
ion and differentiation. This signaling… more
Abstract:This proposal offers the demonstration of an approach to integrate the latest corrosion sensor technology with corrosion structural effects modeling to enable the transition from periodic corrosion inspections to an efficient, focused prognostics and health monitoring (PHM) system. The fundamental… more
Abstract:DESCRIPTION (provided by applicant): Prostate cancer is the most prevalent cancer among men; and the second leading cause of cancer death among men in the US. There are currently no approved therapies for hormone-refractory prostate cancer. Epidemiological
studies have demonstrated a strong… more
Abstract:The Atmospheric Pressure Plasma Jet (APPJr) technology invented at Los Alamos National Laboratory and exclusively licensed to APJeT, Inc., is a revolutionary platform technology enabling economic application of atmospheric pressure plasma technology in an array of applications. APPJr is a… more
Abstract:DESCRIPTION (provided by applicant): Sleep-related breathing disorders (SRBDs), such as sleep apnea, take a heavy public health toll, especially on children. Mounting evidence suggests that these disorders can impact physical and mental development. Diagno
sing and understanding these disorders are… more
Abstract:DESCRIPTION (provided by applicant): The goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents for retinal and choroidal vascular diseases. Because of its critical role in sphingolipid
metabolism, we have focused on SK as an… more
Abstract:DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) is an autoimmune disease that targets insulin secreting pancreatic beta cells for destruction and remains a major cause of morbidity and mortality in over 1% of the population worldwide. Although i
nsulin therapy and islet transplantation… more
Abstract:DESCRIPTION (provided by applicant): The main objective of this proposal is to develop a novel cancer vaccine, ApoVax-SVN(tm) based on the use of a proprietary costimulatory chimeric ligand, 4-1BBL, designed to specifically deliver survivin, a tumor associ
ated antigen (TAA) to professional… more
Abstract:DESCRIPTION (provided by applicant): Various cancer vaccines based on tumor associated antigens (TAAs) or tumor specific antigens (TSAs) have shown efficacy in preclinical models. However, their therapeutic efficacies have been rather limited in clinical
trial settings. Although the reason for… more
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