Abstract:DESCRIPTION (provided by applicant): The broad long term goal of this project is to prevent mother to child transmission of HIV through breast feeding in resource poor countries. In the developing world, perinatal transmission is greatly reduced through relatively simple expedients such as dosing… more
Abstract:DESCRIPTION (provided by applicant): The long term goal of this research is to reduce or eliminate blindness due to diseases of the back of the eye by developing sustained release intravitreal injectable formulations for anti-inflammatory drugs. In previous work, supported in part through SBIR Phase… more
Abstract:Given the vulnerability of the GPS system to intentional or hostile denial of service, it is imperative that the U.S. military develop technologies that provide robust navigation solutions that do not rely on GPS data. To achieve this capability, Aurora and MIT have teamed to develop the Integrated… more
Abstract:The machining of structures from materials such as titanium is typically accomplished using end mills and roughing 90 to 95 percent of the material to leave precise, complex features on thin walled structures. High speed machining is widely used in the manufacture of parts and reduces labor… more
Abstract:DESCRIPTION (provided by applicant): Influenza virus is one of the most important human pathogens accounting for widespread morbidity and mortality. Influenza virus is currently classified as a NIAID Biodefense Category C priority pathogen, a status that may be upgraded due to the recent emergence… more
Abstract:An improved control system for autonomous vehicles is proposed in which prognostic and diagnostic data generated by the vehicle itself is used as an input to the controller. This is in contrast to conventional controllers in which the vehicle is represented by a static model. ASI will analyze the… more
Abstract:There is an urgent need for a man-transportable EOD robot which can quickly traverse the distance between its operator and the suspected UXO, perform manipulation tasks requiring high dexterity, and then quickly return. This proposal describes an innovative solution to this need called `Taz'. Taz… more
Abstract:DESCRIPTION (provided by applicant): The confocal fluorescent microscope directly eliminates the light emitted from out-of-focus internal structures. This has enabled the observation of fluorophore-labeled processes or 3D structures deep within thick specimens. Unfortunately, high performance… more
Abstract:DESCRIPTION (provided by applicant): Impaired or abnormal wound healing is a major health problem for elderly, diabetic, immunosuppressed, immobilized, burn-injured and keloid individuals. Every year in the United States, 6.5 million people have chronic skin ulcers caused by pressure, venous stasis… more
Abstract:Each year, more than sixteen million shipping containers arrive in the US via truck, rail, or container ships. Current inspection regimes rely on cumbersome and expensive procedures such as manual inspection and/or x-ray, gamma ray, and radiation detection technology to determine the risk posed by… more
Abstract:DESCRIPTION (provided by applicant): Typhoid fever is an infectious disease that annually afflicts an estimated 16 million people worldwide, resulting in 600,000 deaths. The etiologic agent of typhoid fever, Salmonella typhi (S. typhi), is transmitted to humans by the fecal-oral route through… more
Abstract:There are solutions available today to secure intra-domain VoIP traffic. This same type of security capability is needed to support cross-domain voice collaboration applications. Avenda Systems proposes a secure inter-domain collaboration enabling solution called SIDCO (Secure Inter-Domain… more
Abstract:AVID LLC proposes a smart material-enabled hovering ducted-fan micro air vehicle (MAV) to greatly enhance the bomb damage information (BDI) capabilities of the U.S. Air Force. Such a design offers a more intuitive search capability for the BDI mission. Unlike fixed-wing MAVs, a ducted-fan MAV… more
Abstract:DESCRIPTION (provided by applicant): Yersinia pestis, the bacterium responsible for plague, is a Category A pathogen, a significant biowarfare agent. If weaponized, it can easily gain direct access to the respiratory system to cause rapid death by pneumonic plague. Pneumonic plague has fatality… more
Abstract:DESCRIPTION (provided by applicant): This phase II SBIR project will test the feasibility of producing large amounts of human monoclonal antibody into transchromosomic avian egg white. We will use a full length ovomucoid genomic locus expression construct created and tested in phase I, to drive… more
Abstract:Basic science discoveries have led to the development of a series of human biotherapeutic drugs for the treatment of cancer and HIV as well as many other diseases. Currently there are over 400 drugs in clinical trials just for the first two diseases. The current biotherapeutics' manufacturing… more
Abstract:The Afloat Master Planning System (AMPS) module of the Navy Data Environment is the authoritative data source for the Fleet Commander Command, Control, Computers, Communication, Combat systems, and Intelligence (C5I) baseline. AMPS has evolved in response to emergent requirements without planning in… more
Abstract:In Phase II, AVYD DEVICES plans to demonstrate the radiation hardened single wave band and dual wave band VLWIR HgCdTe focal plane arrays (FPAs) with fabrication, characterization and delivery to MDA, of 256X256 arrays hybridized to Si Read Out Integration Chips.
Abstract:Phase II objective is to demonstrate and deliver to MDA, Si substrate based co-located 2-color LWIR/LWIR focal plane arrays in a 512x512 or larger format with improved NEI (or NEFD) for enhanced sensitivity.
Abstract:Phase I effort focuses on demonstrating the feasibility of our approach to develop a technology to fabricate large format Multi-Color HgCdTe FPAs. In Phase II, we plan to validate the feasibility established in Phase I with demonstration and delivery of large format two-dimensional arrays hybridized… more
Abstract:DESCRIPTION (provided by applicant): Long-term Objectives Aims: Sexual dysfunction is the most common long-term consequence of cancer treatment, affecting half of survivors of breast and gynecological cancer and many women treated for other cancers. Yet, few women get the help they need for sexual… more
Abstract:In this Phase I DHS STTR proposal submitted in response to Topic H-SB06.2-007, Aymont Technology, Inc. and University of Virginia will develop gallium phosphide (GaP) avalanche photodiodes (APD) with high quantum efficiency (QE>50% at 360 nm in Phase I), high gain (>100000), and high speed (2 GHz… more
Abstract:Historically, biometric collection systems have been designed for fixed Law Enforcement office applications. Their limitations stem from the fact that they were designed for specific hardware collection sensors optimized for a specific application. To a large extent the software is proprietary to… more
Abstract:DESCRIPTION (provided by applicant): LED based curing lights are beginning to replace conventional halogen lamps as the first choice for dental photo-curing applications. The target of this proposal is to develop a new generation LED dental curing light. It will be the first curing light that is… more
Abstract:Low-light-level photodetector arrays are proposed for detecting the weak optical emission spectra from the trace atoms in the laser-induced breakdown spectroscopy (LIBS). The proposed semiconductor image intensifier and low-light-level camera utilize the miniaturized and monolithically integrated… more
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