Abstract:DESCRIPTION (provided by applicant): The long-term goal of this program is to identify and develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism and angiogenesis, we have focused on SK as an… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism, we have focused on SK as an innovative molecular target for the… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective for the treatment of arthritis. Sphingolipids are being increasingly recognized as key mediators of apoptosis, stress responses, cell… more
Abstract:DESCRIPTION (provided by applicant): Cancer is one of the major causes of death in the U.S. and many developed countries with an estimated economic burden of over 100 billion dollars in direct and indirect costs in the U.S. alone. Although surgery, chemotherapy, and radiotherapy are commonly used… more
Abstract:DESCRIPTION (provided by applicant): Acid-prepared mesoporous silica ("APMS") shows significant advances over commercially available silica in high performance liquid chromatography ("HPLC"), a technique commonly used to isolate molecules. HPLC columns containing APMS show dramatically enhanced… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop and implement as software methods for entering, processing, and analyzing species distribution monitoring data, which is one of the most basic forms of biological information that comes from surveys, censuses, and other… more
Abstract:Efforts will focus on the physical and logical interface design for a bidirectional translation device. The deliverable will be a prototype design as well as recommendations on ergonomic factors and interaction requirements of a bidirectional speech driven mobile translation appliance. The design… more
Abstract:DESCRIPTION (provided by applicant): Electric Cell-substrate Impedance Sensing (ECIS) was developed by Applied Bio Physics to study the behavior of cultured cells in real time. Instruments currently find use in over 60 laboratories world wide measuring cell properties such as permeability of cell… more
Abstract:The pulp and paper industry require the removal or bleaching of lignin as an important manufacturing step for many of their products. Chemical bleaching is the preferred current process for whitening because of its relatively low cost. The bleaching process uses large amounts of chlorinated and… more
Abstract:Joint Tactical Radio System (JTRS) is a software radio capable of tuning from 2MHz to 2000MHz. A wideband antenna or a set of antennas are needed to support operation across the entire frequency spectrum of JTRS. To meet this need, Applied EM is proposing an innovative conformal design, which… more
Abstract:Current anti Jam GPS antennas are approximately 14" in diameter making them too large for several platforms of interest such as unmanned aerial vehicles, missiles and fighter aircrafts. A modified version of this antenna array is significantly smaller in size (seven inch diameter) but incorporates… more
Abstract:Providing accurate PVT (Position, Velocity and Time) information is very critical for systems like Joint Precision Approach and Landing System (JPALS). JPALS is a key component enabling U.S. military forces to be highly mobile and capable of "rapid response" on a global basis to a wide range of… more
Abstract:The proposed research effort addresses two main shortcomings in the state-of-art GPS anti-jam systems. One of them relates to antenna size and the other pertains to performance limitation imposed by antenna electronics implementations. The current antenna array GAS-1 CRPA has seven antenna… more
Abstract:Direction Finding (DF) systems on rotorcrafts vehicles and more specifically rotorcraft UAVs suffer from effects on rotorcraft blade modulations. Only coarse DF on rotorcraft has been achieved during the EH-60 QuickFix program. During this effort, Applied EM is proposing to develop very accurate… more
Abstract:This proposal is submitted under the Innovative Tools and Techniques Supporting the Practical Uses of Earth Science Observations topic. We seek to evaluate and demonstrate technical approaches for linking remote sensing rangeland products with a soil biogeochemical model to form a decision support… more
Abstract:This innovative SBIR Phase II proposal will develop next generation products for Thermal Control Material Systems (TCMS) an adhesives based on the next generation nano-cluster chemistry based new binder systems, through the systematic investigations to tailor required unique performance properties… more
Abstract:The purpose of this STTR phase I proposal is to demonstrate the feasibility of producing the survivable multi-functional engineered material systems for spacecraft surfaces at an affordable cost using the proposed novel material designs and processes. The objectives of these efforts are not only to… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research project develops the concept of using hand-held, mobile devices to link the physical world to information networks using advanced pattern and symbol recognition technology that will be deployed on the mobile device. The proposed mobile… more
Abstract:DESCRIPTION (provided by applicant): The population of aging adults in the United States is entering a period of rapid growth as baby boomers get older and life expectancy continues to increase. One problem that is significantly affecting their ability to live and function independently is low… more
Abstract:DESCRIPTION (provided by applicant):
Applied Medical Visualizations has developed a real-time graphical display showing model-based predictions of drug pharmacology (pharmacokinetics and pharmacodynamics), intended for use by anesthesiologists in the operating room. The administration of… more
Abstract:DESCRIPTION (provided by applicant): ALung Technologies, Inc. is developing a respiratory catheter (the Nattier Catheter) for treatment of acute and acute-on-chronic respiratory failure, which affects over 100,000 adults in the United States.
A major limitation in clinical respiratory… more
Abstract:Applied Minds, Inc. (AMI) will prototype a transverse two-virtual-wheel robotic mule that will carry a diesel generator and a small rechargeable battery, and which will be capable of carrying additional loads.
AMI's concept is to build a legged robotic vehicle by replacing the wheels of a… more
Abstract:This SBIR proposal aims to develop all-passive fiberoptic lighting systems that can be used on long space missions or here on earth. By addressing the traditional problems of concentration and solar tracking in a novel way, we will create a high efficiency lighting system that is also very durable… more
Abstract:The use of small unmanned ground vehicles in both military and civilian operations is rapidly growing. Unfortunately, vendors today only offer their own proprietary Operator Control Units and vehicle payloads that can only be used with their vehicle platform. The objective of this Phase I effort is… more
Abstract:Current robotic controllers place a great deal of emphasis on graphical control methods. While graphics and visualization are an important and critical method for controlling robotic assets, they are not sufficient in all cases. The ideal robotic controller would enable the soldier to interact with… more
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