Abstract:We propose to develop a universal strategy to encapsulate protein-based therapeutics using our patented non-toxic, non-immunogenic, water soluble, nanometer size capsules. These nanocapsules have a functionalized surface rendering them "unseen" by the normal immunogenic scavenging response of the… more
Abstract:We propose to develop a multiplexed immunoassay for the detection of 2 - 4 medically relevant biomarkers of traumatic brain injury for use by front-line medical personnel and their civilian equivalents. The assay will provide results in less than 30 minutes, and provide information as to the actual… more
Abstract:Antennovation and the Pennsylvania State University propose to develop novel new electromagnetic bandgap (EBG) materials in conjunction with miniaturized broadband antennas for use in man-portable antenna applications. The proposed antenna/EBG system will be designed to be low-profile, compact, and… more
Abstract:DESCRIPTION (provided by applicant): Numerous studies have demonstrated that homocysteine (HCY) is a major risk factor in heart disease and stroke. Recent studies have shown that lowering HCY levels with large doses of folate have reduced the incidence of cardiovascular disease. However, in… more
Abstract:DESCRIPTION (provided by applicant): The ready availability of pluripotent adult stem cells would have many important therapeutic applications. Our recent results suggest that the hair follicle is a promising source for such stem cells. Our recent discovery that the neural stem cell marker, nestin… more
Abstract:Maskless technology capable of sub-100 nm patterning is attractive for manufacturing of many microelectronic and biomolecular devices. In numerous military applications, the number of different types of electronic modules required is large, whereas the quantities needed of each type of module are… more
Abstract:One of the ultimate goals of sensor research is to build an integrated unit that harnesses its energy from its surroundings and reacts to, and transmits, any changes in its environment in a predictable and reliable manner. There are several components to this universal goal of a self-contained… more
Abstract:This Small Business Innovation Research (SBIR) research project aims to develop a multi-resolution large-area maskless lithography system and process flow for fabricating electronic packages, such as integrated circuit packages, multi-chip modules, and printed circuit boards. This technology will… more
Abstract:It is desirable to develop a high-efficiency lighting source for large-area irradiation of space-based crops. The key requirements for such a system include high efficiency, light weight, easy and rapid deployment, compact storage, ruggedness, and low cost. Furthermore, in order to maximize the… more
Abstract:Highly-integrated, reconfigurable radar antenna arrays fabricated on flexible substrates offer high functionality in a portable package that can be rolled up and transported on the ground, or deployed into space. High levels of integration allow for: reconfigurability of operating frequency and / or… more
Abstract:The primary purpose of this proposal is to study and demonstrate the feasibility of building a fast-running physics based simulation of a warhead that dispenses several independent submunitions from the warhead using a Windows based PC to host the simulation. In the simulation system to be designed… more
Abstract:This Phase I proposal seeks to develop and demonstrate an improved first responder molecular analysis system based on a simplified methodology using aluminum oxide membrane (AOM) integrated sample preparation, amplification, and detection technology. This method has been shown to be faster, simpler,… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will scale-up a new technology for producing high-surface area tantalum powders for the electronic capacitor industry. The existing technology is over 30 years old and cannot keep pace with the needs of smaller electronics, which… more
Abstract:DESCRIPTION (provided by applicant): Influenza virus causes a pandemic disease of the respiratory tract that results in significant human morbidity and mortality. Diagnosis of influenza virus infection during the winter months makes up a large component of the clinical virology workload. The goal… more
Abstract:The goal of this proposal is find novel combinations of approved drugs for the treatment and/or prevention of infection with filoviruses. Ebola and Marburg viruses, the only filoviruses, cause an acute hemorrhagic fever syndrome which has a high mortality rate and poses a significant bio-terrorism… more
Abstract:78147S High-resolution tracking detectors based on silicon CCDs and Active Pixel Sensor (APS) arrays have been valuable tools in Nuclear Physics research, and have contributed to major discoveries. APS mega pixel arrays for fine granularity tracking have already demonstrated advantages over CCDs,… more
Abstract:The objective of this research is to investigate the technical feasibility of building a bidirectional converter to achieve the power density, efficiency, and coolant temperature objectives using an innovative marriage of state-of-the-art technologies. These technologies each represent innovations… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research project will develop highly miniaturized power converters by developing a functional, scaled-down hardware prototype of a high-temperature multichip power module (MCPM). To achieve this goal, the company has taken advantages of the key… more
Abstract:DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a commercial diagnostic for the early detection of age-related macular degeneration (ARMD). It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that… more
Abstract:The Atmospheric Pressure Plasma Jet (APPJr) technology invented at Los Alamos National Laboratory and exclusively licensed to APJeT, Inc., is a revolutionary platform technology enabling economic application of atmospheric pressure plasma technology in an array of applications. APPJr is a… more
Abstract:Global market demands for fresh tuna products have resulted in increased pressure on tuna fisheries worldwide. As a result, consumer driven market pressures have created significant commercial importance in the U.S. market for certain high-value tuna species. Domestic tuna harvests and harvests by… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this program is to identify and develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism and angiogenesis, we have focused on SK as an… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism, we have focused on SK as an innovative molecular target for the… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective for the treatment of arthritis. Sphingolipids are being increasingly recognized as key mediators of apoptosis, stress responses, cell… more
Abstract:DESCRIPTION (provided by applicant): Cancer is one of the major causes of death in the U.S. and many developed countries with an estimated economic burden of over 100 billion dollars in direct and indirect costs in the U.S. alone. Although surgery, chemotherapy, and radiotherapy are commonly used… more
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