Abstract:DESCRIPTION (provided by applicant): The overall goal of this project is to produce large amounts of high-quality copper-67 on a routine basis, at reasonable prices to support cancer research and approved drug products. Researchers using Cu-67 have obtained promising results. Unfortunately this… more
Abstract:New challenges and mission requirements constantly emerge, establishing the need for versatile equipment and instruments to perform the new/expanded tasks. AlphaSniffer propose the development of a compact chemical monitoring system that provides highly sensitive, selective, and rapid detection of… more
Abstract:In shallow water environments or using broadband processing,detection statistics enerated from sonar data can exhibit highly non-Gaussian statistics due to the discrete nature of the returns from different clutter elements in different range resolution cells. Optimal likelihood detectors rely… more
Abstract:79504S05 The growth of large semi-insulating single crystals of aluminum antimonide (AlSb) for the potential application of room temperature, high-energy, gamma-ray radiation detection, needed for radiation detection, is hindered by the presence of melt slag during Czochralski crystal growth. This… more
Abstract:ALTAIR Center in cooperation with the University of Rochester proposes to develop the first silicon-based photonic crystal laser diode. The photonic crystal microcavity forms gain region of the laser diode. This enhances the system efficiency. The laser operating either in bandgap edge emitting mode… more
Abstract:ALTAIR Center in cooperation with the NanoTech Institute at the University of Texas at Dallas proposes to develop a new class of terahertz (THz) lasers generating about 1 mW in the frequency range 0.3-10 THz at room temperature. The proposed concept is based on employing the semiconductor… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will demonstrate superior power-delivery, rapid-charge, and long cycle-life performance of prototype carbon-coated, nanoparticle-based electrodes for use in inherently safe, moderate-to-large sized lithium ion batteries of various… more
Abstract:DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently… more
Abstract:DESCRIPTION (provided by applicant):
Founded in 1998, Altea Therapeutics is developing its PassPort(tm) transdermal drug delivery system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This… more
Abstract:DESCRIPTION (provided by applicant): We propose an innovative approach combining two separate, novel techniques to greatly enhance accurate detection of leukemia or lymphoma cells, which can be used ultimately for diagnostics and early detection of minimal residual disease (MRD) in bone marrow,… more
Abstract:Altex Technologies, a small business entity, and Pennsylvania State University (PSU), a research organization, have teamed up under this STTR program to develop the innovative Person Portable JP-8 Fueled Fuel Cell-Power Generator (PJF-Gen). The 500-1000 watts PJF-Gen system will be light and… more
Abstract:Low temperature Solid Oxide Fuel Cells (SOFC) operating on JP-8 and other distillate fuels are the ideal power sources for all applications, especially for portable power applications. By operating at lower temperature (400-600 C) these systems have faster response, quicker startup, better longevity… more
Abstract:DESCRIPTION (provided by applicant): The objective of this project is to develop an anti-tissue factor antibody, Sunol-cH36, as a treatment for Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). The association between coagulation and inflammation has been well established and… more
Abstract:DESCRIPTION (provided by applicant): The need to develop novel, cost effective manufacturing processes to produce therapeutic antibodies commercially will continue to be of considerable and growing interest to biopharmaceutical and medical industries. The long-term objectives related to this… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is to develop small molecule inhibitors of MHC class II activity for the treatment of rheumatoid arthritis (RA). The strong genetic association between specific MHC class II alleles, such as HLA-DR molecules containing the… more
Abstract:DESCRIPTION (provided by applicant): Sex steroids play important roles in a number of cancers including breast, ovarian, endometrial and prostate cancers. In this proposal, we are planning to investigate means to modulate steroid levels in an effort to suppress tumor growth. During the Phase I of… more
Abstract:DESCRIPTION (provided by applicant): The long term goal of this proposal is the development a new class of pharmacological agents that modulate intraocular pressure by altering the levels of cortisol. Our approach consists of the design of inhibitors for an oxidoreductase that acts as a key… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this proposal is to develop a new class of pharmacological agents that aid in the management of different aspects of the metabolic syndrome by modulating the levels of cortisol. The compounds could also be of use in the management of… more
Abstract:78000 One way to reduce greenhouse gases is to sequester carbon dioxide. Once sequestered, a bioconversion process can convert carbon dioxide into methane, an environmentally friendly energy source. The process requires an abundance of hydrogen, which is present in the hydrogen-rich coal macerals… more
Abstract:79766S05 In order to increase proton energy up to 8 GeV in a driver linear accelerator, particles must be accelerated through various stages and three different power levels (25kW, 100 kW, and 210kw). Unfortunately, no power coupler element for these cavities has ever been produced using U.S.… more
Abstract:79784S05 In superconducting cavities used in nuclear physics research, the detection of impurities on to less than 50 micrometer sizes would enable the cavities to reach the highest possible accelerating fields. Currently available equipment can only inspect flat sheets, which allows for defective… more
Abstract:79412S05 Superconducting radio frequency (RF) cavities (of which the proposed International Linear Collider (ILC) will need several thousand) require ultra clean vacuum and surface cleanness. A break in a ceramic RF coupler window, with consequent inrushing of air and contaminants, would have… more
Abstract:DESCRIPTION (provided by applicant): Helicobacter pylori (Hp), a gastric bacterial pathogen of humans; infection is the cause of type B gastritis and is also strongly associated with gastric carcinoma (intestinal type) and gastric MALT lymphoma. Combination antimicrobial therapy (triple therapy… more
Abstract:DESCRIPTION (provided by applicant):
Significant advances have been made in the development of a new generation of molecularly targeted cancer drugs, many of which are only now emerging from the drug development pipeline. Examples of small molecule drugs are imatinib (Gleevec), used to treat CML,… more
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