Abstract:DESCRIPTION (provided by applicant): Congestive heart failure (CHF) is a complex syndrome characterized by multiple symptoms including fluid retention and shortness of breath (dyspnea). Although these symptoms are currently generally treated by oral loop diuretics, intravenous (IV) delivery of loop… more
Abstract:DESCRIPTION (provided by applicant): Acute agitation is a serious and common complication of a variety of major psychiatric disorders, including dementia, schizophrenia and mania. In addition, it is one of the most detrimental factors in the continued stigmatization of mental illness. The current… more
Abstract:DESCRIPTION (provided by applicant): Breakthrough pain is a feared symptom afflicting the majority of cancer patients at some point in their illness. It is characterized by rapid onset, with pain intensity reaching excruciating level within several minutes, and brief duration (median duration… more
Abstract:DESCRIPTION (provided by applicant): Asthma is a chronic disease characterized by inflammation of the airways and lung, causing attacks characterized by wheezing and shortness of breath. Around 5% of the population in the United States suffers from asthma, with the prevalence of this disease… more
Abstract:DESCRIPTION (provided by applicant): Algos Therapeutics, Inc., a biopharmaceutical company, seeks funding for early drug discovery research designed to validate two proprietary ion channels as molecular targets for treatment of neuropathic pain. Neuropathic pain is initiated by nerve damage and… more
Abstract:DESCRIPTION (provided by applicant): In the broadest terms, the goal of the proposed work is to make it easier for researchers to apply robust, scalable, entity-centered, heterogeneous data access to the biomedical literature. 'Entity centered' means that information is indexed irrespective of what… more
Abstract:We propose to develop a new fiber optic splice that is designed for military and aerospace avionic applications. The purpose of the Phase I program is to demonstrate the feasibility of our proposed approach. The new fiber optic splice is intended to meet stringent military and avionic requirements… more
Abstract:We propose to develop a new fiber optic cleaning system that is designed for low-cost, effective cleaning, compact size, and ease of use. The purpose of the Phase I program is to demonstrate the feasibility of our proposed approach. The comprehensive cleaning system incorporates a solvent cleaning… more
Abstract:We propose to develop an optical Improvised Explosive Device (IED) activity detection system that is designed for military applications. The purpose of the Phase I program is to demonstrate the feasibility of our proposed approach. The proposed system is intended to detect tampering with or… more
Abstract:It makes great economical and environmental sense to recycle A/C C-C brake. Used C-C brake composites, both 2D and 3D, are available in large quantities but to date have found limited use due to their thinness and annular shape. In Phase I, we have successfully demonstrated the feasibility of… more
Abstract:Advanced ceramic-based composite heat exchanger offers the potential to reduce weight, improve heat exchanger performance, increase aircraft payload, and decrease life-cycle cost. Under the proposed Phase II effort, Allcomp plans to develop a full-size composite Fan Duct heat exchanger for JSF… more
Abstract:Our research program is focused on achieving high thermal performance in a high temperature carbon-carbon (C-C) radiator especially designed to fulfill present and future challenges in outer space applications. The radiator is one of the key parts in heat rejection systems, in both power conversion… more
Abstract:Carbon-carbon (C-C) composites are the state-of-the-art friction material for aircraft brakes. Generally speaking, C-C brake offers low wear and provides excellent frictional performance at high energy conditions such as rejected take off (RTO). The use of C-C aircraft brakes adds safety, increases… more
Abstract:High-performance and high-power electronic semiconductor devices, such as solid state lasers, solid state motor drivers, RF power amplifiers, radar T/R modules among others, are used extensively in military and commercial applications. As the devices get more powerful while their volumes and weights… more
Abstract:Nuclear Electric Propulsion (NEP) technology holds great promise for power and propulsion demands of NASA current and future deep space explorations. Closed Brayton Cycle (CBC) space power system is one of the most efficient energy conversion technologies for nuclear electric propulsion. There are… more
Abstract:DESCRIPTION (provided by applicant): Undiagnosed sources of pain are a frequent, though often a nonspecific presenting symptom of numerous medical conditions. A classic attempt to make pain a more specific diagnostic in conjunction with anatomical knowledge is when the Doctor palpates a particular… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to develop an ultrasound particle agglutination (UPA) method for determination of pathogenic bacteria Escherichia coli O157:H7 and Listeria monocytogenes in body fluids, food and environmental samples. The UPA assay is based on… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to demonstrate the feasibility of a novel method for detection of human immunodeficiency virus (HIV) antibody in the body fluids. The method is based on the use of ultrasound to significantly increase the sensitivity and reduce… more
Abstract:75374-In response to the DOE¿s desire to identify spin-off technology from its Magnetic Fusion Energy program, this project addresses the identification of unexploded ordnance, using a nuclear assay with neutrons produced by fusion reactions. In particular, a portable neutron source will be… more
Abstract:75252 The development of fusion energy would be quickened if spin-off applications could be identified and commercialized. In this spirit, this project will develop a nuclear assay that uses a high intensity neutron source based on an inertial electrostatic confinement (IEC) plasma device… more
Abstract:DESCRIPTION (provided by applicant):
Almen Laboratories has developed a sophisticated software system for imaging applications that provides extensive tools to identify objects and image features of interest, analyze the information content and then store, retrieve and compare different objects… more
Abstract:DESCRIPTION (provided by applicant): This proposal will create tools to link repositories of biochemical pathway information via a graph like annotation system. We will use these tools to annotate KEGG, a popular repository of pathway information. Current biochemical information is fragmentary, and… more
Abstract:This Small Business Innovation Research Program Phase II project will develop advanced forms of transparent network proxies for both satellite and terrestrial broadband wireless communications to the Internet. Shared wireless access links to the Internet often exhibit what has been called a traffic… more
Abstract:DESCRIPTION (provided by applicant): Elevated intracranial pressure (ICP) remains a critical problem in management of patients with neurological problems and is the most common cause of death in these patients. Elevated ICP can be managed and treated if detected at an early stage. Therefore,… more
Abstract:Alpha Omega Electromagnetics LLC. has proposed a novel, bandwidth-tunable array radiating element architecture. This technology will support advanced technology multi-octave dual-polarized radar or electronic warefare-based phased array radiating apertures. In this SBIR program, it is our objective… more
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