Abstract:DESCRIPTION (provided by applicant): Because proteins and large macromolecular drugs do not normally cross epithelial barriers (i.e., intestine and lung), they are parenterally administered to patients. Injection is invasive and not well-accepted by patients or the medical community. Delivery of… more
Abstract:DESCRIPTION (provided by applicant): We have discovered a new method for administering proteins to the pulmonary system by a noninvasive technique using a receptor-mediated process. Because injection is invasive and not well accepted by patients, or the medical community, this method should be well… more
Abstract:The need is becoming ever greater for smaller, lighter, more compact, and higher density power electronics. With the introduction of SiC power diodes and the coming availability of high-temperature SiC power switches on the commercial market, the powerelectronics industry stands on the threshold of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on the implementation of a blue-light converter based on a novel structure of KTiOPO4 (KTP) crystal. It proposes to integrate quasi-phase-matched (QPM) second-harmonic generation (SHG) with 90 degrees phase-matched… more
Abstract:DESCRIPTION (provided by applicant): The dementia of Alzheimer's Disease (AD) is caused by the buildup in the brain over many years of amyloid. Therefore, the development of a brain scan that measures brain amyloid could identify those individuals at risk for the later development of AD. Early… more
Abstract:DESCRIPTION (provided by applicant): There presently is no neuroprotective agent that can be given to patients with acute stroke. The costs for rehabilitation of patients that survive a stroke are greater than $40 billion per year in the U.S. The reason that an effective neuroprotective drug has not… more
Abstract:This proposal describes an SBIR Phase II program to develop, optimize, and demonstrate the effectiveness of hybrid composite armor for AAAV. Hybrid composite armor systems, comprised of unique combinations of dissimilar composite materials, offer lightweight protection at a much lower cost than… more
Abstract:The objective of this Phase I proposal is to demonstrate specific mine-blast-resistant crew seat design concepts that can attenuate or absorb the high G loading, with lowest weight and cost possible. A computer simulation will be presented to identify therequired shock absorber characteristics.… more
Abstract:DESCRIPTION (provided by applicant):
Manipulation of objects on a microscopic scale can be done conveniently with a device known as a laser or optical tweezers. While laser trapping was originally devised for trapping Rayleigh particles (i.e. particles much less than the wavelength of the… more
Abstract:DESCRIPTION (provided by applicant):
Manipulation of objects on a microscopic scale can be done conveniently with a device known as a laser or optical tweezers. While laser trapping was originally devised for trapping Rayleigh particles (i.e. particles much less than the wavelength of the… more
Abstract:In consideration of the operational requirements of the US Navy VSW/MCM forces to transport marine mammals, this investigation evaluates alternative hullform and innovative technologies to reduce shock transmission to occupants and mammals. Specifically,this investigation evaluates and compares the… more
Abstract:DESCRIPTION (provided by applicant): The objective of the proposed research is to develop clinically applicable DNA microarray methods for detecting chromosome imbalance (e.g. aneuploidy) in isolated cells. Such tests will be widely applicable and we anticipate their use in several areas: 1)… more
Abstract:DESCRIPTION (provided by the applicant): Autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes, and multiple sclerosis, are thought to arise from abnormalities of innate or adaptive immune responses. Autoimmune diseases are often difficult to diagnose, as… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to define methodology to facilitate the growth of engineered cartilage tissue for use in a multi-well culture system for drug discovery. Culture systems, which are currently available to study the affect of potential… more
Abstract:DESCRIPTION (provided by applicant): This small business Innovation Research Phase I project proposes to define methodology to facilitate the growth of engineered cartilage tissue. Recent studies have demonstrated that the alginate recovered chondrocyte (ARC) method can be used to stimulate… more
Abstract:In the 2002 Small Business Innovation Research Solicitation, the U.S. Environmental Protection Agency explicitly expressed interest in instruments that can accurately and reliably measure particulate emissions from vehicles. The availability of suitable instruments for measuring particulate… more
Abstract:The Phase II basic effort seeks to develop and test a prototype PDI cloud probe for reliable and accurate measurement of the cloud droplet size distribution from airborne platforms. The key features of this device are high accuracy and precision of dropletsizing, large dynamic range, accurate… more
Abstract:The Phase II basic effort seeks to develop and test a prototype PDI cloud probe for reliable and accurate measurement of the cloud droplet size distribution from airborne platforms. The key features of this device are high accuracy and precision of dropletsizing, large dynamic range, accurate… more
Abstract:Given two closely related pieces of software X and Y, where Y differs from X through a number of small but important (from a security point of view) modifications that were done to Y, the
Abstract:Ascension Technology proposes to develop a fast, six degrees-of-freedom tracker, phasorBIRD, immune to cockpit and helmet scatterers of magnetic/electrical field energy. It will integrate seamlessly with helmet-mounted displays in tactical aircraft,tracked ground vehicles, and combat air operations… more
Abstract:Ascension Technology proposes to develop a fast, six degrees-of-freedom tracker, phasorBIRD, immune to cockpit and helmet scatterers of magnetic/electrical field energy. It will integrate seamlessly with helmet-mounted displays in tactical aircraft,tracked ground vehicles, and combat air operations… more
Abstract:Ascension Technology proposes to develop a fast, new six degrees-of-freedom tracker, phasorBIRDTM, immune to cockpit and helmet scatterers of magnetic/electrical field energy. It will integrate seamlessly with training simulators, aircraft, tanks, andcombat air operations centers (CAOCs). Design… more
Abstract:DESCRIPTION (provided by applicant):
Ultrasound is widely used for imaging of blood vessels because it is non-invasive, real-time, and relatively inexpensive. Reliable quantitative evaluation of blood vessels plays a pivotal role in cardiovascular disease diagnosis and follow-up intervention to… more
Abstract:72383S03-I Conventional waveguide windows have power-handling limitations that severely restrict linear accelerator performance. This project will develop a novel microwave window concept that directly addresses the electrical and thermal stress limitations of conventional waveguide windows,… more
Abstract:Early and effective hemodialysis can decrease mortality of trauma patients with acute renal failure. Unfortunately, current technology is not easily deployed in the field or during transport of patients. The Sorbent Hemodialysis (SHD) System now beingdeveloped using technology from Ash Medical… more
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