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Year:2002
Company: Acellent Technologies, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2002 / 1
Abstract: Acellent Technologies is developing a Hybrid piezoelectric/fiber optic (HyPFO) structural diagnostic system that can be used to perform quick non-destructive evaluation and long-term health monitoring of aerospace vehicles and structures. The development is based on Acellent's state-of-the-art SMART… more
Company: ACERA BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): The structural and biosynthetic similaritybetween FR900482 and mitomycin (MC) group of antitumor antibiotics makes it
promising to rationally create novel mitomycin/FR900482 hybrids through
combinatorial biosynthesis. After successful identification of both MC… more
Company: ACI TECHNOLOGIES, INC. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "ACIT has studied a remotely addressed strain detection system consisting of a passive embedded sensor and a handheld detector, used in either a stationary or portable mode. This Proposal will demonstrate the utility of the strain detection system forspecific advanced composite materials used in… more
Company: ACIONT, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): Phenylketonuria (PKU) is a genetic deficiency of phenylalanine hydroxylase (PAH). Without PAH, the patient with PKU cannot metabolize phenylalanine (PHE) to tyrosine. The resulting accumulation of PHE and the accumulation of phenylpyruvate by a secondary… more
Company: ACIONT, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: The accurate measurement of blood glucose concentration is important in the management of diabetes. Current methods of glucose monitoring involve piercing the skin and collecting blood samples for analysis up to four times daily or more. Even the non-invasive Glucowatch tm glucose monitoring system… more
Company: Acorda Therapeutics, Inc. Agency/Program/Year/Phase: HHS / STTR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): The primary goal of the current research will be to select the best recombinant form of one of two naturally occurring human igM antibodies demonstrated to stimulate remyelination to further develop for clinical testing in inflammatory demyelinating disease, such… more
Company: Acoustech Corporation Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "A study is proposed in which the performance of an underwater acoustic vector sensor (AVS) containing conventional piezoelectric transducers is compared with that of an AVS containing single crystal piezoelectric transducers. An acoustic vector sensor isa device that measures three orthogonal… more
Company: Acoustech Corporation Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "Acoustech proposes a Phase I study to develop an acoustic dyadic sensor using piezoelectric single crystals. The study combines theoretical and numerical modeling along with experimental data obtained from a pre-prototype unit to assess the feasibility ofdeveloping a full scale unit during Phase… more
Company: ACOUSTIC IDEAS, INC. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 2
Abstract: "Nondestructive inspection is a key component of programs aimed at extending the service life of aging aircraft. One important capability is the detection of cracking and corrosion around fastener holes. In thick, multiple layer structures, there is oftenno solution but removal of the fasteners… more
Company: ACOUSTIC IDEAS, INC. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "Current manufacturing technology for cast titanium components cannot guarantee theabsence of hard alpha inclusions.Under the effect of fatigue, such inclusions become likely sites for structuralfailure. By performing nondestructive inspections on the manufactured parts usingphased array ultrasound,… more
Company: ACRYMED, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: Collagen based biosynthetic materials have profoundly improved the outcome of reconstruction and restoration of congenital defects and traumatic injuries. This has been most apparent for massive burn victims that historically suffered lifelong severe scarring and lost of function following wound… more
Company: ACTA Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "The proposed project will demonstrate the feasibility of developing a Stochastic Neural Network for Missile Reliability Prognostics. A neural network model will be developed to predict missile reliability based on the environmental history of particularmissiles. Prediction training will be… more
Company: Active Decision Support, Ltd. Agency/Program/Year/Phase: NSF / SBIR / 2002 / 1
Abstract: This Small Business Innovation Research (SBIR) Phase I project is aimed at developing a general platform for conducting combinatorial auctions. It is proposed to develop a bidding language and user interface, along with a system architecture for an integrated combinatorial auction platform that can… more
Company: Active Motif, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): DNA damages are key events during carcinogenesis. Deficiencies in repairing damaged DNA represent a poor prognosis during tumorigenesis and/or cancer treatment. Besides monitoring DNA damage formation, it would be helpful to monitor DNA repair protein activity.… more
Company: Active Motif, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): The aim of this proposal is to develop a
series of fluorogenic imaging molecules, which can be easily delivered into
viable cells and monitor cellular functions. The FIMs are composed of a peptide
backbone containing a target site for a kinase or a protease. Some… more
Company: Active Motif, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): This proposal focuses on the development of multi-well ELISA-like assays to quantify DNA binding activity of two breast cancer prognosis markers, Sp1 and ER, with much more sensitivity and high throughput than standard DNA gel shift techniques. Such an approach… more
Company: Active Parallel Instrumentation, Inc Agency/Program/Year/Phase: NASA / SBIR / 2002 / 1
Abstract: API proposes to develop a comprehensive toolkit for the construction of real-time diagnostics of aerospace systems. The toolkit includes modular ruggedized hardware components, based upon a COTS design, scalable from 400MFLOPS to 40 GFLOPS or more. Hermetically sealed, thermal managed processors in… more
Company: ACTIVE SHOCK, INC. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "A shock mitigating suspended seat which places the Special Forces Operator in an optimal ergonomic position will be developed for use in small Maritime Combatant Craft. It will feature an actively controlled shock absorber to optimize the suspension for abroad range of operator weights and sea… more
Company: Active Signal Technologies, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: "Active Signal Technologies proposes to develop an active noise reduction (ANR) stethoscope that will enable detection and discrimination of heart and breathing sounds in the high noise environment of a UH-60 BlackHawk helicopter. We will enhance ourdirect contact sensor technology, which already… more
Company: Active Signal Technologies, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): Active Signal Technologies, in partnership with the Brain Attack Team of the University of Maryland Medical Center, proposes to refine and test a novel portable, non-invasive system that will enable rapid identification of stroke. Approximately 750,000 people… more
Company: Active Signal Technologies, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 2
Abstract: DESCRIPTION (provided by applicant): Active Signal Technologies, in partnership with the Brain Attack Team of the University of Maryland Medical Center, proposes to refine and test a novel portable, non-invasive system that will enable rapid identification of stroke. Approximately 750,000 people… more
Company: ACTIVESITE BIOTECH Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: Alzheimer's disease (AD) is a debilitating mental disorder that results in a progressive loss of cognitive functions. However, there is no effective treatment for this disease. The neurotoxin AB peptide plays a central role in AD, involving increased production and accumulation of AB in brain… more
Company: ACTIVESITE BIOTECH Agency/Program/Year/Phase: HHS / SBIR / 2002 / 2
Abstract: Alzheimer's disease (AD) is a debilitating mental disorder that results in a progressive loss of cognitive functions. However, there is no effective treatment for this disease. The neurotoxin AB peptide plays a central role in AD, involving increased production and accumulation of AB in brain… more
Company: MOBILEROBOTS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: Our nation faces increasing challenges in meeting the special needs of elderly and disabled individuals. Non-ambulatory persons with visual impairment, diminished upper-body mobility, spasticity/tremors, memory/attention deficits and other problems may require extraordinary care measures because… more
Company: ACTIVX BIOSCIENCES Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: DESCRIPTION (provided by applicant): Chemical probes will be developed to profile toxicities resulting from drug interactions. We have developed fluorescent probes that exclusively identify active members of the serine hydrolase super-family of enzymes. Using our technique, we can elucidate activity… more
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