Abstract:65526 Current and next generation experiments in nuclear and particle physics require detectors with high spatial resolution, fast response, and accurate energy information. However, in many nuclear physics experiments, the existing detector technology is the limiting factor. This project… more
Abstract:65526 Current and next generation experiments in nuclear and particle physics require detectors with high spatial resolution, fast response, and accurate energy information. However, in many nuclear physics experiments, the existing detector technology is the limiting factor. This project… more
Abstract:65689 For an increasing number of human diseases, smaller animals such as mice and rats can serve as effective models. Accordingly, high-resolution radionuclide imaging, such as positron emission tomography (PET), of small animals can contribute unique information. However, clinical PET scanners… more
Abstract:Scientists have used laser-induced breakdown spectroscopy (LIBS) over the past decade to perform elemental analysis of soil, water and gases. The formation of laser-induced plasma, which produces a localized blackbody source for atomic emissions, enables this technology. Collection of the plasma's… more
Abstract:Scientists have used laser-induced breakdown spectroscopy (LIBS) over the past decade to perform elemental analysis of soil, water and gases. The formation of laser-induced plasma, which produces a localized blackbody source for atomic emissions, enables this technology. Collection of the plasma's… more
Abstract:65584 The monitoring of tritium on various surfaces at DOE facilities presents unique challenges for dosimetry and health-risk assessment. Thus, there is a need for a hand-held, direct-reading instrument. So far, the methods proposed for this purpose have not had the sensitivity (or required… more
Abstract:70001 Current and next generation experiments in nuclear and particle physics require detectors with high spatial resolution, fast response, and accurate energy information. In many nuclear physics experiments, existing detector technology is the limiting factor. This project will… more
Abstract:70062 Gamma ray spectrometers are an important tool for checking the proliferation of the nuclear weapons. The requirements for the ?-ray spectrometers used in this application include good energy resolution, high detection efficiency, compact size, light weight, portability, and low power… more
Abstract:65584 The monitoring of tritium on various surfaces at DOE facilities presents unique challenges for dosimetry and health-risk assessment. Thus, there is a need for a hand-held, direct-reading instrument. So far, the methods proposed for this purpose have not had the sensitivity (or required… more
Abstract:70000 Scintillation spectrometers, consisting of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of nuclear and elementary particle physics experiments. However, the performance of detection systems used in these experiments is often limited… more
Abstract:65689 For an increasing number of human diseases, smaller animals such as mice and rats can serve as effective models. Accordingly, high-resolution radionuclide imaging, such as positron emission tomography (PET), of small animals can contribute unique information. However, clinical PET scanners… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a new intraoperative imaging probe based on a solid-state, compact readout sensor coupled to a high resolution, high light output converter. Nuclear Medicine imaging has been widely used to preoperatively image… more
Abstract:This Phase II SBIR builds on the exciting results demonstrated during the Phase I research. Using a new approach for enhancing the near-infrared (IR) sensitivity of high gain avalanche photodiodes (APDs), Radiation Monitoring Devices, Inc. (RMD) will develop a reliable procedure to produce APD… more
Abstract:This Phase II SBIR builds on the exciting results demonstrated during the Phase I research. Using a new approach for enhancing the near-infrared (IR) sensitivity of high gain avalanche photodiodes (APDs), Radiation Monitoring Devices, Inc. (RMD) will develop a reliable procedure to produce APD… more
Abstract:DESCRIPTION (provided by applicant):Positron Emission Tomography (PET) is an in vivo analog of autoradiography, which makes it a potentially powerful new tool for imaging biological processes and molecular targets in small laboratory animals. Its fundamental advantage is that functional data can be… more
Abstract:DESCRIPTION (provided by applicant):Positron Emission Tomography (PET) is an in vivo analog of autoradiography, which makes it a potentially powerful new tool for imaging biological processes and molecular targets in small laboratory animals. Its fundamental advantage is that functional data can be… more
Abstract:DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) has become an important tool in the fight against cancer. PET is now being used in diverse studies ranging from basic research in animal models of cancer in the mouse, through to diagnosis and staging of cancer patients in the… more
Abstract:Nuclear medicine techniques (such as SPECT) have the potential to become powerful new tools in imaging biological processes in small laboratory animals. With the every increasing number of human disease models, particularly in the smaller animals such as mice and rats, the potential of high… more
Abstract:DESCRIPTION (provided by applicant):
Nuclear Medicine imaging has been widely used to preoperatively image
structures of interest for excisional biopsy. Radio-guided intraoperative
procedures utilizing radiotracers have facilitated a cost-effective, highly
specific means to locate suspect tissue and… more
Abstract:In this Phase I work, we propose to carry out the research necessary to develop, test, and characterize a sophisticated, by avalanche-photodiode (APD) arrangement as a compact, high-performance replacement for photomultiplier tubes used in flow cytomers. Development of a high- performance,… more
Abstract:DESCRIPTION (provided by applicant):The proposed Phase II research focuses upon an application specific integrated circuit (ASIC) that is necessary to support new avalanche photodiode (APD) and lutetium orthosilicate (LSO) detector module designed for small-animal PET applications. Based on our… more
Abstract:DESCRIPTION (provided by applicant):The proposed Phase II research focuses upon an application specific integrated circuit (ASIC) that is necessary to support new avalanche photodiode (APD) and lutetium orthosilicate (LSO) detector module designed for small-animal PET applications. Based on our… more
Abstract:DESCRIPTION (provided by applicant): Nuclear medicine techniques (such as SPECT) have the potential to become powerful new tool in imaging biological processes in small laboratory animals. With the ever increasing number of human disease models, particularly in the smaller animals such as mice and… more
Abstract:Dedicated high-resolution small animal imaging systems have recently emerged as important new tools for cancer research. These systems permit noninvasive screening of animals for mutations
or pathologies and to monitor disease progression and response to therapy. One
imaging modality, x-ray… more
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