Abstract:Epilepsy is a debilitating disorder affecting 1 adult in 200 in the United States. Although several drugs are valuable for epilepsy therapy, their poor aqueous solubility does not permit effective formulation for intravenous administration. No IV formulation exists for carbamazepine (CBZ), a drug of… more
Abstract:Our company will formulate a protease inhibitor, KNI-272, to improve bioavailability following oraladministration. This will be accomplished using patented technology to convert this nearly water-insspherical, amorphous, uniformly-sized submicron particles suspended in a biocompatible aqueous… more
Abstract:In the operation of passive sonar systems, some Contacts Of Interest (COIs) radiate detectable amounts of broad band energy; on the other hand, their narrow band components are too weak for initial detection, yet are required for classification. Our new approach to such systems is based on envelope… more
Abstract:Visidyne proposes to design and develop a prototype rendering system for the visualization of stochastic cloud images for use in Distributed Interactive Simulation (DIS) applications. Using numerical integrals fo 3-dimensional or volumetric cloud properites the system will determine the radiometric… more
Abstract:Visidyne proposes to develop an expert, neural net based, system for classifying cloud types based on texture analysis in satellite imagery using geometric measures as network inputs. In Phase I Visidyne proposes to investigate the utility of a variety of network inputs based on the geometry and… more
Abstract:The fiber/polymer interfacial adhesion in a biodegradable composite determines the mechanical integthe initial (dry) interfacial adhesion is enhanced through the use of coupling agents or other surfadestroyed as the fiber breakdown. Up until now, biodegradable composites have tended to lose their… more
Abstract:PAVEMENT DISTRESS DATA ARE UTILIZED DURING PAVEMENT EVALUATION, DESIGN, REHABILITATION, MAINTENANCE, MANAGEMENT, AND RESEARCH. CURRENTLY, THE MANUAL SURVEY METHOD, UTILIZING PAPER AND PENCIL, IS USED EXTENSIVELY IN COLLECTING THE DISTRESS DATA, BUT THIS PROCESS IS SLOW, TEDIOUS, EXPENSIVE, AND PRONE… more
Abstract:There is a need for optical crystals, having large nonlinear coefficients and low optical absorption in the mid IR region (2-5 m). Crystals of KTA have shown promise in this application, however, improved optical transmission is still required. The synthesis, crystal growth and characterization of… more
Abstract:The use of ZnGeP2 in nonlinear optical applications has been limited in the past due to an extrinsic absorption in the near infrared. Defect studies of ZnGeP2 indicate that the extrinsic absorption is due to nonstoichiometry (as a result of high volatility of some components at the temperatures… more
Abstract:There is a need for optical materials with large nonlinear coefficients and high laser damage thresholds for tunable laser operation in the 2-5um region. This proposal describes a new member of the KTP family CsZrOAsO4 (CZA), which is expected to have superior properties in comparison to KTP. An… more
Abstract:Protein kinases play a key role in the regulation of metabolic activities in eukaryotic cells. A laprotein kinases have been isolated and characterized, but we are still in the early stages of undersphosphorylation on the target proteins. Better tools are needed to study protein kinases and the… more
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