Abstract:High voltage semiconductor devices have found important applications in the areas of high power generation, power control, power conversion, surge protection, and industrial electronics. However, GaAs or Si based high voltage device are limited by a relatively low intrinsic breakdown voltage and… more
Abstract:We propose a six month Phase I research program aimed at developing compliant substrates for the epitaxy of GaN and AlGaN films. We present two alternate approaches one with silicon and the other with GaAs as the starting substrate material and a unique multilayer structure to be deposited using low… more
Abstract:THE END OF THE COLD WAR HAS SWITCHED THE FOCUS FROM BUILDING WEAPONS OF DETERRENCE TO MINIMIZING THE CHANCES FOR THE USE OR PROLIFERATION OF NUCLEAR WEAPONS. THUS, ARMS CONTROL VERIFICATION AND THE CAREFUL MONITORING OF THE NUCLEAR NON-PROLIFERATION TREATY ARE ESSENTIAL COMPONENTS OF ANY… more
Abstract:NUMEROUS COMPOUNDS SHOWING ANTINEOPLASTIC ACTIVITY HAVE BEEN IDENTIFIED IN THE ORGANIC SOLVENT EXTRACTS OF PLANT MATERIAL, MICROORGANISMS, AND MARINE ORGANISMS. FURTHER INVESTIGATION INTO THE UTILITY OF THESE COMPOUNDS AS CHEMOTHERAPEUTIC AND ANTI-HIV AGENTS HAS BEEN HAMPERED BY THEIR LOW NATURAL… more
Abstract:This Phase I effort will investigate the feasibility of basic concepts for a hillside straddle tractor. A true straddle tractor for tall crops on hillsides does not currently exist. This straddle tractor, the Smart Mountain Mule (SMM), will be designed as a tool for Christmas tree farms in hilly… more
Abstract:Crystallization of membrane-proteins has been a difficult problem because of their peculiar physiconature. We will develop detergents that closely mimic the biological milieu inhabited by membrane prdetergents are expected to form large micelles; thereby, allowing the formation of larger, and… more
Abstract:We have described a new technology called "preparative in situ hybridization (Prep-I.S.H.), which is capable of isolating a set of cDNA or genomic clones according to their chromosome location. The technology takes advantage of in situ hybridization of cloned DNAs to metaphase chromosome spreads,… more
Abstract:Our research decribes a strategy for producing a high density set of PCR-base microsatellite markerpolymorphic in L5178Y, the cell line used in the mouse lymphoma assay (MLA). These polymorphic marketwo detailed long range restriction maps in the vicinity of the thymidine kinase (tk-1) gene, with… more
Abstract:This proposal describes a set of reagents which will make gene mapping to chromosomes and chromosomas well as gene finding exercises, accessible to any molecular biologist or geneticist familiar withtechniques. These reagents, called the Gene. ID system, are a set of "dot-blots". The "Chromosome… more
Abstract:We propose using new molecular techniques to survey the spectrum of mutagenic events occurring at tL5178Y cells. We will compare this spectrum with the range of abnormalities occurring in human cancemouse lymphoma assy (MLA) as an accurate reflection of events of human significance. Specifically… more
Abstract:Long term objective is to purify DNA of fetal origin, starting with a sample of maternal blood. Thtechnology to be used with a variety of Diagnostic Methods including Polymerase Chain Reaction (PCR)Genomic Hybridization (CGH), Electrophoresis. The whole human genome becomes analyzable for a… more
Abstract:Reconnaissance and surveillance missions, using small robust spacecraft, may require that sensors be rapidly positioned to suit the specific mission requirements. These maneuvers are most effectively conducted using a CMG with an output torque of 2-100 ft.-lbs.; however, the smallest CMG currently… more
Abstract:This Phase I project is for the development of a concept that integrates a printed circuit board with a high stiffness, high thermal conductivity composite material structure to achieve a multifunctional structural electronics packaging product for spacecraft application. The project involves… more
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