Abstract:ABSTRACT: The objective of this STTR Phase II project is to continue the development of a fine scale forecast model capability that will provide a technologically superior, high resolution atmospheric decision tool to accurately predict areas of clear air turbulence in the upper troposphere and… more
Abstract:Our approach for protecting critical program information in US weapons systems from exploitation or reverse-engineering efforts is based on a new sensor technology. Utilizing advances in the field of nanotechnology and the sub-field of plasmonics, our design is miniscule in size and allows for… more
Abstract:The goal of this project is to develop STC101, a biosmilar Herceptin . Trastuzumab is a monoclonal antibody made against the HER2 protein that is overexpressed in 20-25% of patients with breast cancer. Because of high cost associated with prescribing Herceptin , a generic version of this drug would… more
Abstract:Goals of 80% clean energy production for the United States by 2035 and 20% of the countrys power being supplied by wind energy by 2030 imply nearly a tenfold increase in wind power production. This means that the need for forecast information will extend to longer projection windows with increasing… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project addresses the need for breakthrough technologies in the production of ultrahigh temperature (UHT) ceramics, including nanograin structures, with improved performance-to-cost ratio. UHT ceramics are often challenging to densify. The… more
Abstract:The Army has identified the need to enhance existing ground-based surveillance platforms by utilizing polarimetric imaging (PI). Situational awareness imagery has become a vital tool for locating and helping to neutralize roadway threats. The urgency of these threats demands quick, cost effective… more
Abstract:The objectives of this proposal are to further preclinical development of unique two-photon-activated photodynamic therapy (TPPDT) triads that incorporate a nontoxic porphyrin photosensitizer, a tumor targeting group, and an imaging functionality, providing for noninvasive image-guided treatment of… more
Abstract:A growing body of research underscores the need to prepare students socially—as well as academically—to ensure successful transition to middle school and foster subsequent academic success. This project team is developing a prototype of a series of web-based interactive games to help students… more
Abstract:DESCRIPTION (provided by applicant): Over the past several decades, a large number of mental health (MH) practices and interventions have been rigorously tested through randomized control trials and shown efficacious. However, despite availability, evidence-based interventions (EBIs) are rarely… more
Abstract:DESCRIPTION (provided by applicant): Clinical science and its translation into preventive and clinical patient care are the primary means by which the nation's health care goals are fulfilled. NIH's broad mission to improve health outcomes for all people can only be achieved if scientific… more
Abstract:DESCRIPTION (provided by applicant): Non-suicidal self-injury (NSSI) is an increasingly common self-harming behavior among adolescents and young adults, with current estimates of NSSI in youth ranging from 12-37%. Although NSSI is associated with other mental health problems (e.g., depression,… more
Abstract:DESCRIPTION (provided by applicant): Although high school success and completion are among the most important determinants of future life outcomes, over half a million adolescents in the United States drop out of school each year. School dropout has negative individual (e.g., increased likelihood of… more
Abstract:DESCRIPTION (provided by applicant): As emphasized by the NIH Roadmap and NCRR's Strategic Priorities, NIH's broad mission to improve health outcomes for all persons depends on the ability to train and retain future generations of clinical and translational researchers who can quickly and… more
Abstract:The World Health Organization estimates that more than one-third of the worldwide population is infected with Mycobacterium tuberculosis (MTB), the causative agent of most cases of tuberculosis (TB). Patients who are infected with MTB, but do not have active TB disease have latent tuberculosis… more
Abstract:DESCRIPTION (provided by applicant): The prevalence of nutrition-related conditions (overweight/obesity, cancer, diabetes, heart disease, etc.) among Americans is widely documented. During the last twenty years, the frequency of dining out has increased, with Americans currently eating… more
Abstract:ABSTRACT: There is a current need to remove the use of EHC on landing gear component bores (non-line of sight). EHC has been utilized on landing gear components for numerous years. There are many benefits to EHC such as providing an excellent wear surface, a good corrosion barrier and it allows… more
Abstract:Landing gear systems are one of the more problematic subsystems on Naval aircraft. Landing gear failure can be caused by hard landings due to actual severe high sink rate with high enough GW to exceed the design strength, but are extremely rare. More common are fatigue and environmentally caused… more
Abstract:ABSTRACT: Chrome plating has been utilized for Aircraft, Landing Gear, Engine and Propeller components for over half a century, and High Velocity Oxygen Fuel (HVOF) tungsten carbide (WC-Co, or WC-Co-Cr) coatings are currently being utilized for chrome replacement on many aerospace components and… more
Abstract:ABSTRACT: Aircraft structure, engine, propeller and landing gear systems utilize high and low strength steel, cad-plated threaded components and fasteners throughout its structure. Threaded components and fasteners manufactured from these alloys require sacrificial protective coatings due to the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project concerns the development of an optical fiber biosensor platform that achieves exceptionally high sensitivity through use of a nanoscale, high refractive index, self-assembled polymer coating on the cladding surface. A rapid, specific,… more
Abstract:Atmospheric aerosols influence the earths radiation balance through direct scattering and absorption of radiation, and through alteration in the formation, brightness and extent of clouds. The concentrations and size distribution of aerosols aloft is important to these effects. Needed is a method to… more
Abstract:DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction.… more
Abstract:DESCRIPTION (provided by applicant): In the present STTR we propose to investigate two novel approaches in our exploration of the therapeutic and regenerative potential of cell-based medicine. Furthermore, we will utilize a preclinical animal model of compression syndrome (CS) that mimics the… more
Abstract:DESCRIPTION (provided by applicant): This STTR Phase II application is to finalize the one-of-its-kind Assessment of Liability and Exposure to Substance use and antisocial behavior(c) (ALEXSA(c)) for educator, pediatric, prevention and epidemiology uses. The ALEXSA system, first funded by a NIDA… more
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