Abstract:ABSTRACT: The objective of this STTR Phase II project is to continue the development of a fine scale forecast model capability that will provide a technologically superior, high resolution atmospheric decision tool to accurately predict areas of clear air turbulence in the upper troposphere and… more
Abstract:The goal of this project is to develop STC101, a biosmilar Herceptin . Trastuzumab is a monoclonal antibody made against the HER2 protein that is overexpressed in 20-25% of patients with breast cancer. Because of high cost associated with prescribing Herceptin , a generic version of this drug would… more
Abstract:Goals of 80% clean energy production for the United States by 2035 and 20% of the countrys power being supplied by wind energy by 2030 imply nearly a tenfold increase in wind power production. This means that the need for forecast information will extend to longer projection windows with increasing… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project addresses the need for breakthrough technologies in the production of ultrahigh temperature (UHT) ceramics, including nanograin structures, with improved performance-to-cost ratio. UHT ceramics are often challenging to densify. The… more
Abstract:The objectives of this proposal are to further preclinical development of unique two-photon-activated photodynamic therapy (TPPDT) triads that incorporate a nontoxic porphyrin photosensitizer, a tumor targeting group, and an imaging functionality, providing for noninvasive image-guided treatment of… more
Abstract:A growing body of research underscores the need to prepare students socially—as well as academically—to ensure successful transition to middle school and foster subsequent academic success. This project team is developing a prototype of a series of web-based interactive games to help students… more
Abstract:DESCRIPTION (provided by applicant): Over the past several decades, a large number of mental health (MH) practices and interventions have been rigorously tested through randomized control trials and shown efficacious. However, despite availability, evidence-based interventions (EBIs) are rarely… more
Abstract:DESCRIPTION (provided by applicant): Clinical science and its translation into preventive and clinical patient care are the primary means by which the nation's health care goals are fulfilled. NIH's broad mission to improve health outcomes for all people can only be achieved if scientific… more
Abstract:DESCRIPTION (provided by applicant): Non-suicidal self-injury (NSSI) is an increasingly common self-harming behavior among adolescents and young adults, with current estimates of NSSI in youth ranging from 12-37%. Although NSSI is associated with other mental health problems (e.g., depression,… more
Abstract:DESCRIPTION (provided by applicant): Although high school success and completion are among the most important determinants of future life outcomes, over half a million adolescents in the United States drop out of school each year. School dropout has negative individual (e.g., increased likelihood of… more
Abstract:DESCRIPTION (provided by applicant): As emphasized by the NIH Roadmap and NCRR's Strategic Priorities, NIH's broad mission to improve health outcomes for all persons depends on the ability to train and retain future generations of clinical and translational researchers who can quickly and… more
Abstract:The World Health Organization estimates that more than one-third of the worldwide population is infected with Mycobacterium tuberculosis (MTB), the causative agent of most cases of tuberculosis (TB). Patients who are infected with MTB, but do not have active TB disease have latent tuberculosis… more
Abstract:DESCRIPTION (provided by applicant): The prevalence of nutrition-related conditions (overweight/obesity, cancer, diabetes, heart disease, etc.) among Americans is widely documented. During the last twenty years, the frequency of dining out has increased, with Americans currently eating… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project concerns the development of an optical fiber biosensor platform that achieves exceptionally high sensitivity through use of a nanoscale, high refractive index, self-assembled polymer coating on the cladding surface. A rapid, specific,… more
Abstract:Atmospheric aerosols influence the earths radiation balance through direct scattering and absorption of radiation, and through alteration in the formation, brightness and extent of clouds. The concentrations and size distribution of aerosols aloft is important to these effects. Needed is a method to… more
Abstract:DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction.… more
Abstract:DESCRIPTION (provided by applicant): In the present STTR we propose to investigate two novel approaches in our exploration of the therapeutic and regenerative potential of cell-based medicine. Furthermore, we will utilize a preclinical animal model of compression syndrome (CS) that mimics the… more
Abstract:DESCRIPTION (provided by applicant): This STTR Phase II application is to finalize the one-of-its-kind Assessment of Liability and Exposure to Substance use and antisocial behavior(c) (ALEXSA(c)) for educator, pediatric, prevention and epidemiology uses. The ALEXSA system, first funded by a NIDA… more
Abstract:The primary technical objective to be achieved during Phase II is the transition from the developed laboratory prototype, which clearly demonstrated the feasibility and superior outcomes of the approach, to a deployable system consisting of two key elements (the reference station - compression side… more
Abstract:DESCRIPTION (provided by applicant): Cardiotoxicity, as a result of adverse drug effects, is a serious problem that has yet to be effectively screened prior to patient exposure. Cardiac safety is one of the leading causes of compound attrition in the pharmaceutical industry and withdrawal of… more
Abstract:Environmental Benefits: The proposed technology relates to Climate change and sustainable energy. Fatty acids are currently produced from palm oil, 80% of which comes from Malaysia and Indonesia. Both these countries have finite land available and often times rainforests are destroyed to make way… more
Abstract:For long-term exploratory space travel, there will be a critical need for in-situ diagnosis and assessment of biological specimens from symptomatic astronauts, especially, disease pathogens (virus, bacterium, or fungus) and microbial contaminants. Hence, a real-time, non-culture-based microbial… more
Abstract:An accurate predictive capability of coupled fluid-structure interaction in propulsion system is crucial in the development of NASA's new Space Launch System (SLS). This STTR effort will develop a multi-disciplinary tool to improve CFD prediction capability in modeling coupled fluid structure… more
Abstract:ABSTRACT: The goal of this project is to develop theoretical models for electrode erosion in high-pressure arcs and incorporate them into computational tools for simulations of arc heaters. The complexity of the electrode material removal process is associated with the multi-phase nature of the… more
Abstract:ABSTRACT: The overall goal of the proposed effort is to develop and demonstrate a general-purpose, fast, and reliable management and learning software tool for analyzing massive data sets generated by dynamic multi-disciplinary simulations. The salient elements of the software tool are: (1) an… more
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