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Displaying 141601 – 141625 of 146890 Awards
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THIS PROJECT WILL PRODUCE MOUSE AND RAT MONOCLONAL ANTIBODIES TO THE LEUKEMOGENIC HUMAN RETROVIRUS, HTLV-I. STABLE, IMMUNOGLOBULIN-SECRETING HTLV-I ELISA-REACTIVE SUBCLONES WILL BE ISOLATED AND THEIR VIRAL ANTIGEN SPECIFICITY CONFIRMED BY IMMUNOPRECIPITATION, WESTERN BLOTTING, AND IMMUNOFLUORESCENCE… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: HTLV-III/LAV IS A RECENTLY DESCRIBED HUMAN RETROVIRUS LINKEDBOTH MOLECULAR- AND SEROEPIDEMIOLOGICALLY TO THE CURRENT EPIDEMIC OF AIDS. IT SHOULD BE POSSIBLE NOT ONLY TO INTERFERE WITH VIRAL PROPOGATION IN A CHEMOTHERAPEUTIC MANNER BUT ALSO TO EFFECT IMMUNOPROPHYLAXIS IN THE AT-RISK POPULATION, AS… more
Company: GENELABS TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: THE HUMAN IMMUNE RESPONSE IS GOVERNED BY ORDERED INTERACTIONS BETWEEN FUNCTIONALLY AND PHENOTYPICALLY DISTINCT LYMPOID CELLS (T CELLS AND THEIR SUBSETS, B CELLS) AND MONOCYTES IN THE CONTEXT OF IA-LIKE MOLECULES ENCODED BY THE HLA COMPLEX OF GENES. THUS,THE PRODUCTS OF THESE HLA CLASS II GENES (DP… more
Company: General Digital Industries Inc Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: IN AN EFFORT TO COMPENSATE FOR THE DECLINING SKILL LEVELS OF SHIPYARD WELDERS, THIS PROGRAM RESEARCHES THE FEASIBILITY OF BUILDING AN ADAPTIVE WELD CONTROL SYSTEM USING A RULE-BASED EXPERT SYSTEM AND APPROPRIATE SENSORS. THE SHIPYARD WELDING PROCESS THAT CAN BENEFIT MOST FROM SUCH A CONTROL SYSTEM… more
Company: General Oceanics Inc Agency/Program/Year/Phase: DOE / SBIR / 1986 / 1
Abstract: N/A
Company: General Pneumatics Corp Agency/Program/Year/Phase: NASA / SBIR / 1986 / 2
Abstract: CRYOCOOLERS AND GAS LIQUEFIERS UTILIZE ISENTHALPIC EXPANSION OF COOLED GAS IN JOULE-THOMSON NOZZLES. TO EFFECTIVELY OPTIMIZE USAGE OF THE COMPRESSED GAS, A VARIABLE GAS MASS FLOW RATE IS NECESSARY. A HIGH FLOW RATE IS REQUIRED INITIALLY WITH A PROGRESSIVE REDUCTION AS THE DESIGN CONDITION IS… more
Company: General Sciences, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: THE USE OF HIGHLY EXOTHERMIC SELF PROPAGATING INTERMETALLIC REACTIONS IN PROPOSED TO BOND TOGETHER LOW COST ANISTROPIC GRAPHITIC MATERIALS WHICH HAVE SHOWN PROMISE AS LASER RESISTANT MATERIALS DUE TO HIGH REFLECTIVITY AND HIGH HEAT OF VAPORIZATION. IN ADDITION SEVERAL TECHNIQUES ARE PROPOSED IN… more
Company: General Sciences, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: N/A
Company: General Technology Inc Agency/Program/Year/Phase: DOD / SBIR / 1986 / 2
Abstract: A NEW HIGH-FREQUENCY, NONFOULING, FOUR-ELECTRODE, OPEN-CELL CONDUCTIVITY SENSOR FOR OCEANIC USE IS PROPOSED. THIS SENSOR IS TO REPLACE THE COMMONLY USED CONDUCTIVITY CELL MADE BY N. BROWN INSTRUMENT SYSTEM. THE NEW SENSOR WILL BE DESIGNED TO MINIMIZE OR ELIMINATE PROBLEMS ASSOCIATED WITH N. BROWN… more
Company: General Technology Inc Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: N/A
Company: GENESIS LABORATORIES, INC Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: THE LONG-TERM OBJECTIVE OF THIS WORK IS TO DEVELOP A RAPID, COLORIMETRIC, INSTRUMENT-DEPENDENT ASSAY FOR CARDIO-DIGITALIS CONSTITUENTS, NOTABLY DIGOXIN AND DIGITOXIN. GENESIS LABS' ""IMMUNOSTRIP'' ASSAY (PROTECTED BY PATENT) IS CONSTRUCTED IN A CONFIGURATION THAT IS APPLICABLE FOR THE RAPID… more
Company: Genesys Research, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: IN VITRO CYTOGENETIC TESTS TO EVALUATE THE GENETIC HAZARDS OF CHEMICALS ARE INCREASING IN IMPORTANCE FOR PREDICTING IN VIVO EFFECTS. IN PARTICULAR, STUDIES HAVE DEMONSTRATED (1) THE RELEVANCE OF CHROMOSOMAL MUTATION TO INHERITANCE IN GERMCELLS; (2) THAT SPECIFIC CHROMOSOMAL DEFECTS ARE ASSOCIATED… more
Company: Genesys Research, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: N/A
Company: Genetic Diagnostics Corp Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: RECENT ADVANCES IN BIOCHEMISTRY AND IMMUNOLOGY NOW MAKE POSSIBLE NEW APPROACHES FOR DETECTION AND TREATMENT OF INFECTIOUS DISEASES. OUR GROUP IS COMMITTED TO SUCH TECHNOLOGICAL APPLICATIONS, AND THIS PHASE I PROPOSAL IS IN RESPONSE TO THE STATED INTEREST OF THE N.I.A.D.A. IN SUCH INNOVATIVE… more
Company: Genetic Diagnostics Corp Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: AS THE USE OF MARIHUANA HAS CONTINUED TO GROW, THE NEED FOR ACCURATE AND RELIABLE MEANS OF MEASURING CANNABINOID LEVELS HAS BECOME MORE URGENT. THIS PHASE I APPLICATION OUTLINES OUR INTEREST IN DEVELOPING SUCH A CANNABINOID ASSAY WHICH WILL BE RAPID, NON-ISOTOPIC, AND CAPABLE OF BEING PERFORMED IN A… more
Company: Genetics Data Services Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: N/A
Company: Genetics Institute Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: CURRENT TECHNIQUES FOR THE DIAGNOSIS OF GENETIC DISEASE ARE LIMITED BY AN INABILITY TO DETECT THE MAJORITY OF MUTATIONS AND POLYMORPHISMS IN DNA. DNA MOLECULES THAT DIFFER BY ONE OR A FEW BASE PAIRS CAN MOST EFFICIENTLY BE DISTINGUISHED BYDENATURING GRADIENT GEL ELECTROPHORESIS DUE TO SEQUENCE… more
Company: Genetics Institute Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE OBJECTIVE OF THE PROJECT IS TO ESTABLISH HUMAN HEMATO- POIETIC PROGENITOR GROWTH FACTOR-DEPENDENT CELL LINES IN CULTURE. TO ACCOMPLISH THIS, RESEARCHERS WILL FIRST DESIGN AND CONSTRUCT RETROVIRAL VECTORS THAT CAN INFECT AND EXPRESSCLONED GENES IN APPROPRIATE CELL TYPES. THESE WOULD CARRY BOTH A… more
Company: Genetics Institute Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: N/A
Company: Genetics Institute Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: N/A
Company: Genex Corpon Agency/Program/Year/Phase: DOC / SBIR / 1986 / 1
Abstract: BOVINE PANCREATIC RIBONUCLEASE A (RNASE A) IS A MODEL SYSTEMFOR ESTABLISHING RULES THAT GOVERN PROTEIN STABILITY AND FOLDING. BY LEARNING AND APPLYING THESE RULES, MORE ROBUST ENZYMES OF VARIOUS TYPES COULD BE DESIGNED FOR COMMERCIAL APPLICATIONS. SYNTHESIS, CLONING AND EXPRESSION IN… more
Company: Genex Corpon Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: L-ASPARAGINASE IS AN IMPORTANT ADDITION TO COMBINATION CHEMOTHERAPY PROTOCOLS FOR CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA. HOWEVER, IMMUNOLOGICAL REACTIONS TO THIS FOREIGN PROTEIN CAN GREATLY LIMIT ITS THERAPEUTIC EFFECTIVENESS. THEREFORE, THE PRODUCTION OF NON-CROSS REACTING L- ASPARAGINASE VARIANTS… more
Company: Genex Corpon Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: N/A
Company: Genzyme Corp. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE SPECIFIC AIM OF THIS PHASE I PROJECT IS TO PURIFY TO HOMOGENEITY ACIDIC A-D-MANNOSIDASE FROM HUMAN PLACENTAS AND BOVINE KIDNEYS. IT IS ANTICIPATED THAT BY EMPLOYING A COMBINATION OF CHROMATOGRAPHIC TECHNIQUES ON AFFINITY, HIGH-PERFORMANCE ANION EXCHANGE, AND/OR HIGH PERFORMANCE GEL FILTRATION… more
Company: GEO-CENTERS, INC. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: THE DEVELOPMENT OF A MINIATURIZED ALL SOLID STATE MAGNETIC SENSOR CHIP IS PROPOSED. THE SENSOR EXPLOITS THE MAGNETOELASTIC RESPONSE OF AN AMORPHOUS METAL FILM. PHASE I RESEARCH IS DIRECTED TOWARDS ESTABLISHING THE PRINCIPLE OF OPERATION OF THE PROPOSED SOLID STATE MAGNETIC SENSOR, IDENTIFYING THE… more
Displaying 141601 – 141625 of 146890 Awards
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