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Company: H. G. Pars Pharmaceutical Labo Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: H. G. PARS PHARMACEUTICAL LABORATORIES' LONG-TERM GOAL IS TO DEVELOP AND MARKET AN ORALLY ACTIVE ANTIHYPERTENSIVE DRUG FROM ITS SERIES OF SULFUR AND NITROGEN CANNABINOID ANALOGS. HYPOTENSIVE CANNABINOIDS ARE BELIEVED TO EXERT THEIR EFFECTS BY ALTERING CENTRAL SYMPATHETIC NERVOUS SYSTEM ACTIVITY BUT… more
Company: H. G. Pars Pharmaceutical Labo Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE MODIFICATION OF -LACTAM ANTIBIOTICS CONTINUES TO BE A PROMISING MEANS FOR THE IMPROVEMENT OF THIS VERY IMPORTANT CLASS OF ANTIMICROBIALS. THE VARIED USEFUL ATTRIBUTES OF THE NEW OXACEPHALOSPORIN MOXALACTAM, NAMELY BROAD SPECTRUM OF ACTIVITY, FAVORABLE PHARMACOKINETIC PROFILE, AND STABILITY,… more
Company: H. G. Pars Pharmaceutical Labo Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: CURRENT BACTERIOCIDAL AND FUNGICIDAL AGENTS ARE UNSATISFACTORY FOR USE ON SENSITIVE SOFT TISSUE OR MUCOUS MEMBRANE. THERE IS NO KNOWN CHEMICAL AGENT WHICH POSSESSES BROAD-RANGE BACTERIOCIDAL AND FUNGICIDAL ACTIVITY AND IS NONIRRITANT TOWARDS OCULAR TISSUE. THE DISCOVERY OF SUCH AN AGENT WOULD BE… more
Company: H. G. Pars Pharmaceutical Labo Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND REVERSIBLE, IS NOT CURRENTLY AVAILABLE. GOSSYPOL, THE MOST PROMISING NONSTEROIDAL MALE ANTIFERTILITY LEAD, HAS AN UNACCEPTABLY NARROW THERAPEUTIC RATIO. WE PROPOSE THAT THE THERAPEUTIC RATIO MAY BE IMPROVED BY ALTERATION OF THE… more
Company: Hss, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1985 / 2
Abstract: IF SUCCESSFUL THIS PROGRAM SHOULD LEAD TO THE DEVELOPMENT OF THE VISIBILITY SENSOR REQUIRED BY THE ARMY FOR THE TMQ-30 AUTOMATED METEOROLGICAL STATION. A FURTHER BENEFIT TO THE ARMY WILL ENSURE IF THE FEASIBILITY OF ADDING A PRESENT WEATHER CAPABILITY TO THE SENSOR CAN BE DEMOSTRATED. THE VISIBILITY… more
Company: Hampshire Instruments, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: UNDERSTANDING THREE-DIMENSIONAL STRUCTURAL RELATIONSHIPS IN CELLS AND TISSUES IS IMPORTANT IN BOTH BASIC MEDICAL SCIENCE AND CLINICAL PATHOLOGY DIAGNOSIS. TO HELP ADDRESS THIS NEED, HAMPSHIRE INSTRUMENTS IS DEVELOPING A HIGH-RESOLUTION THREE-DIMENSIONAL OPTICAL MICROSCOPY WORKSTATION WITH… more
Company: Handicapped Childrens Technolo Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: A STUDY IS PROPOSED WHICH WILL DETERMINE THE FEASIBILITY OF DEVELOPING A COMPUTER BASED MODEL FOR ADMINISTERING ASSESSMENT AND THERAPY TO MENTALLY RETARDED/DEVELOPMENTALLY DISABLED INFANTS AND CHILDREN. THE PRINCIPAL AIM OF PHASE I IS TO SURVEY CURRENT TECHNOLOGIES AS THEY RELATE TO THERAPY AND… more
Company: Hauser Laboratorytories Agency/Program/Year/Phase: DOD / SBIR / 1985 / 2
Abstract: SELECTIVE APPLIATION OF TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION (TENS) FOR PAIN CONTROL HOLDS PROMISE IN THE AREA OF DENTAL ANESTHESIA. APPLICATION OF A NOVEL CARBON FIBER ELECTRODE WITH A SOPHISTICATED YET SIMPLE CONTROL UNIT, WILL LEAD TO AFFECTIVE PAIN CONTROL IN DENTAL APPLICATIONS.… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: USDA / SBIR / 1985 / 2
Abstract: WE PROPOSE TO DEVELOP AN IMMUNOASSAY FOR THE PESTICIDE, CARBOFURAN. PHASE I WILL CONSIST OF SYNTHESIZING SUITABLE HAPTENS, CONJUGATING THESE HAPTENS TO AN IMMUNOGENIC CARRIER, PREPARING AND SCREENING RABBIT ANTISERA, AND CONDUCTING PRELIMINARY COMPETITIVE ELISA TESTS TO DEMONSTRATE THE FEASIBILITY… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE OBJECTIVE OF THIS PROJECT IS TO USE IMMUNOLOGICAL METHODS TO PURIFY AND CHARACTERIZE THE 50 KDA ANOREXIGEN ISOLATED PREVIOUSLY IN LOW YIELDS USING CONVENTIONAL PROCEDURES. A SMALL AMOUNT OF THE PURIFIED ANOREXIGEN IS PRESENTLY AVAILABLE AND WILL BE USED TO GENERATE A SET OF MONOCLONAL ANTIBODIES… more
Company: Enslein Research, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 2
Abstract: THIS PROPOSAL DEALS WITH THE DEVELOPMENTOF STRUCTURE ACTIVITY EQUATIONS (MODELS) FOR THE DRAIZE SKIN AND EYE IRRITANCY TESTS. THE APPLICANT HAS PREVIOUSLY DEVELOPED SUCH MODELS FOR RAT ORAL LD(50), MUTAGENICITY, CARCINOGENICITY, TERATOGENICITY, AND BIODEGRADABILITY. THE PRINCIPLES USED IN THE… more
Company: Hem Research, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE GOAL OF THIS RESEARCH PROJECT IS TO DEVELOP A NUCLEIC ACID HYBRIDIZATION ASSAY FOR HTLV-III/LAV VIRAL DNA AND MRNA WHICH CAN BE COMPLETED WITHIN TWO HOURS, HAS MINIMAL BIOHAZARD ASSOCIATED WITH PERFORMING THE TEST, AND IS APPROPRIATE FOR AUTOMATION. THE PROBE ASSAY WILL BE TESTED FOR SENSITIVITY… more
Company: Hemascience Laboratorytorie Agency/Program/Year/Phase: HHS / SBIR / 1985 / 2
Abstract: DEMANDS FOR WASHED RED BLOOD CELLS IS INCREASING. THIS IS IN PART TO AWARENESS OF TRANSFUSION RELATED DISEASE SUCH AS HEPATITIS AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). EXISTING TECHNOLOGY FOR CELL WASHING IS INEFFICIENT IN THAT A SIGNIFICANT AMOUNT OF FINAL WASHED PRODUCT IS OFTEN LOST IN… more
Company: Hepar Industries, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: CURRENTLY THERE IS NO EFFECTIVE ORAL PROPHYLACTIC FOR THROMBOEMBOLIC DISORDERS. AS A RESULT, AFFLICTED INDIVIDUALS MUST RECEIVE SINGLE OR MULTIPLE INJECTIONS OF MEDICATION EACH DAY. THE EFFECTIVENESS OF HEPARIN AS AN ANTICOAGULANT IS WELL KNOWN. HOWEVER, HEPARIN MUST BE ADMINISTERED BY INJECTION.… more
Company: Hittite Microwave Corporation Agency/Program/Year/Phase: DOD / SBIR / 1985 / 1
Abstract: N/A
Company: Hittman Materials And Agency/Program/Year/Phase: DOE / SBIR / 1985 / 2
Abstract: A METHOD IS PROPOSED FOR THE METALLIZATION OF MACHINEABLE GLASS-CERAMICS BY THE APPLICATION OF THIN FILM ACTIVE METALS WHICH WILL THEN PERMIT BRAZING OF CERAMIC-TO-METAL AND CERAMIC-TO-CERAMIC ASSEMBLIES. THROUGH PROPER CONTROL AND APPLICATIONS OF THE ACTIVE METAL IT WILL BE POSSIBLE TO OVERCOME THE… more
Company: Hokenson Co Agency/Program/Year/Phase: DOD / SBIR / 1985 / 1
Abstract: A TWO-DECK BOUNDARY LAYER MODEL OF THE FLOW OVER AN ABLATING (AND/OR TRANSPIRING) SURFACE IS PROPOSED IN ORDER TO COMPUTE THE SURFACE ROUGHNESS AND TEMPERATURE DISTRIBUTION IN THE WALL AND FLOW FOR A GIVEN SET OF WALL AND FREESTREAM CONDITIONS. THE OUTER FLOW OF THE TWO-DECK MODEL RESEMBLES A… more
Company: Homogenetics Inc. Agency/Program/Year/Phase: USDA / SBIR / 1985 / 1
Abstract: A RAPID AND VERY SENSITIVE BIOLUMINESCENT IMMUNOASSAY WILL BE USED FOR TRHE DETECTION AND MEASUREMENT OF SALMONELLA BACTERIA IN FOODS. BOTH POLYCOLONAL AND MONOCLONAL ANTIBODIES TO SALMONELLA WILL BE USED. IT IS HOPED TO ATTAINDETECTION LIMITS OF A FEW HUNDRED BACTERIA PER ML. IN AN ASSAY TAKING… more
Company: Hoover Keith & Bruce Inc Agency/Program/Year/Phase: HHS / SBIR / 1985 / 2
Abstract: THIS PROPOSAL IS DIRECTED TOWARD THE CONTROL TECHNOLOGY RESEARCH AREA TO BE SPONSORED BY THE NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH. IN PHASE I, A SYSTEMATICAL INVESTIGATION WILL BE PERFORMED OF THE NOISE GENERATED DURING THE PROCESS OF HONING CYLINDERS. THIS NOISE IS OF INTEREST… more
Company: Horizon Information Systems Agency/Program/Year/Phase: DOD / SBIR / 1985 / 1
Abstract: THE ABILITY TO ACCURATELY ESTIMATE SOFTWARE DEVELOPMENT COSTS AS EARLY AS POSSIBLE IS CLEARLY OF GREAT IMPORTANCE IN CHOOSING BETWEEN DIFFERENT SYSTEM ALTERNATIVES. UNFORTUNATELY, THE PRESENT STATE OF THE ART LEAVES MUCH TO BE DESIRED, FOR AT LEAST TWO BASIC REASONS: THE ABSENCE OF GOOD… more
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