Abstract:DESCRIPTION (provided by applicant): Diabetes is a serious, life-threatening disease caused by improper absorption and metabolism of glucose. Increased glucose levels can lead to an accumulation of toxic sugar degradation products, such as methylglyoxal (MG), in the bloodstream. MG is a reactive… more
Abstract:DESCRIPTION (provided by applicant): Recent advances in massively parallel cDNA sequencing (RNA-seq) have paved the way for comprehensive analysis of the transcriptome, a set of all RNA molecules including mRNA, rRNA, tRNA and other non-coding RNAs in oneor more populations of cells. RNA-Seq can… more
Abstract:DESCRIPTION: Oil spills can cause tremendous environmental damage and are a serious threat to public health. Petroleum contains many toxic compounds, including polyaromatic hydrocarbons (PAHs). Some PAH compounds are highly carcinogenic and cause DNA mutations in humans. When petroleum is spilled… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to make next generation sequencing technology for small RNA more quantitative and less biased. High throughput sequencing has transformed the landscape of genomic research with its ability to produce gigabases of data in a single… more
Abstract:ABSTRACT: 5-D Systems (5-D) has developed a concept for a state-of-the-art Vision Processor for Helmet Systems (VPHS) that will provide significant performance improvements over currently deployed systems. Our concept will achieve the government"s performance requirements and address the two… more
Abstract:5-D is developing a cost effective, militarized, power line communications (PLC) system leveraging commercial"Smart Grid"and PLC technologies. Our approach provides the system components necessary to properly manage the variable resources and loads inherent in micro grid power systems… more
Abstract:Solar water heaters are a well-established renewable energy technology that has been widely adopted outside of the United States. Here we propose to significantly improve the evacuated solar tube collectors (ETC) by utilizing the dry-drawable carbon nanotube (CNT) sheets for solar energy absorption… more
Abstract:Crossfield Technology LLC proposes the design and development of an Accelerated Processing Unit (APU) System on Chip (SoC) consisting of a hybrid CPU/GPU digital signal processor. The APU incorporates high-speed interfaces to external sensors and a NAND Flash Controller. The NAND Flash Controller… more
Abstract:ABSTRACT: Crossfield Technology proposes the development of a high-performance Solid State Disk (SSD) for on-board sensor data storage along with Ground Support Equipment (GSE) to download data from the SSD to a secondary data storage system. Crossfield's approach will provide increased… more
Abstract:ABSTRACT: Crossfield Technology proposes a Fermi Cluster for Real-Time Hyperspectral Scene Generation. The system architecture features heterogeneous processors for real-time scene generation, a high-throughput (10-40 Gbps), very-low-latency communications fabric, and a synchronous hyperspectral… more
Abstract:We will develop automatic ontology-aligning software, leveraging the enormous existing Cyc AI system to drive the formulation and ranking (pro/con argumentation) of hypotheses about term-term relationships, especially where the relationship is not simple 1-to-1 correspondence. Multiple Cyc… more
Abstract:Our proposal describes a multi-functional, non-lethal (NL) warhead for miniature organic precision munitions, which combines: kinetic, blast, flash, dazzle and chemical effects in a single warhead designed to provide incapacitating effects out to 4.25m. The first innovation involves high-density,… more
Abstract:ABSTRACT: Our concept is designed to create and disperse a vapor cloud from a low-vapor-pressure fuel at near stoichimetric conditions and then detonate or at least deflagrate the cloud with a single event system. Our concept relies upon rapid shock compression of the fuel followed by flash… more
Abstract:The need to access parallel computing resources is ever expanding, as both the scale of simulations and the size of data sets are quickly growing. Also, the increasing ubiquity of parallel hardwaremulti-core chips, parallel co-processors and accelerators, near effortless cluster computing on cloud… more
Abstract:FPGAs are widely used in nearly every DoD electronics system because of their processing capabilities, low NRE costs, field programmability, and time to market advantages over ASICs. However, FPGAs"greatest strength reconfigurability is also the source of their low performance and high power… more
Abstract:To enable NASA's next-generation missions, there is a critical need for a reconfigurable FPGA that can withstand the wide temperatures ranges and radiation of the space environment while consuming minimal power without compromising on performance. To address this need, GoofyFoot Labs proposes… more
Abstract:One of the very important issues in many industries is bonding of dissimilar materials, since high bond resistance to high and rapid thermal and mechanical loads is required. The problems associated with the bond durability stem from fundamental differences in the coefficients of thermal expansion… more
Abstract:Invocon's Wireless Intra-vehicle Communication System (WICS) is being designed as an enabling technology for low-cost launch vehicles. It will reduce the cost of these vehicles in primarily three ways:1. Minimizing vehicle weight by decreasing bulky cables and connectors - this increases the… more
Abstract:Invocon has devised a method to determine the location of lightningstrikes on structures to as close as 1" by combining simple sensorswith highly capable electronics. This method measures a strike frommultiple transducers to triangulate its location. Initial testing on metallic and composite… more
Abstract:Invocon, Inc. proposes the development and testing of a Hypervelocity Impact Damage Assessment system that can track the electrical charge dispersion created when a hypervelocity impact (HVI) occurs between two entities with a closing velocity greater than 1 km per second. This same system can… more
Abstract:ABSTRACT: Invocon proposes its Radiation Environment Monitor for Spacecraft (REMS) as a method to provide real-time space radiation weather information for satellites and other spacecraft. REMS measures, stores, and communicates information about radiation dose, dose rate, and angle of incidence.… more
Abstract:DESCRIPTION (provided by applicant): MALDI tissue imaging, when enabled by Nanoparticulate (NP) Matrix implantation, is maturing into a useful preclinical tool for biomarker and drug discovery in our laboratory and at NIDA-IRP. Quantitatively reproducibleimages from serial coronal sections suggest… more
Abstract:The tremendous amount of information available to the analyst is both an opportunity and a problem. Clearly, more information provides analysts with a better foundation for their analyses. However, as the amount of information increases, analysts are finding it more and more difficult to take… more
Abstract:iSee (IC the augmentation of intuitive decision making using Computation) is a framework that will enable accelerated, accurate intuitive Decision Making (iDM). Knowledge Based Systems, Inc. (KBSI) will model iDM based on the functioning of our brains to improve decision-making performance by… more
Abstract:We propose to design and develop a Cohort Development and Analysis Toolkit (CDAT) that will assist clinicians, practice administrators and public health professionals in comparing the effectiveness of different clinical practices, including preventive and treatment modalities. The overall goal of… more
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