Abstract:DESCRIPTION (provided by applicant): Biotherapeutics is a fast-growth sector in the pharmaceutical market with monoclonal antibodies accounting for almost 50% of the 100 billion USD spent each year on protein therapies. Bacterial fermentation, which accounts for about 35% of all protein therapeutics… more
Abstract:DESCRIPTION (provided by applicant): In today's biopharmaceutical pipeline, monoclonal antibodies (mAbs) are a predominant modality for a broad range of clinical indications including oncology and inflammatory diseases. Most antibody therapies have to be administered to the patients in large… more
Abstract:Complex skin defects, including burns and trauma, represent a major medical problem affecting both military and civilian populations. In recent military engagements, burns account for approximately 5% of combat casualties. Furthermore, approximately 1.25 million Americans each year require medical… more
Abstract:DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop an innovative in vitro assay for the classification of skin sensitizers that permits evaluation of chemicals within the highly relevant context of a three-dimensional model of human skin that more closely mimics the… more
Abstract:DESCRIPTION (provided by applicant): Human health has benefited tremendously from the therapeutic application of monoclonal antibodies (mAb), treating painful and devastating diseases such as rheumatoid arthritis and cancer, among others. However, mAb development is a laborious and time consuming… more
Abstract:DESCRIPTION (provided by applicant): Remarkable improvements in throughput, accuracy and cost-effectiveness of next-generation sequencing (next-gen) technologies are ushering in a new era of clinical medicine. Genome wide association studies (GWAS) in particular have begun to leverage these advances… more
Abstract:Convincing scientific evidence has associated dietary choices with chronic disease expression. Dietary guidelines now in place are designed to prevent the onset of such chronic diseases as tissue-specific cancers, cardiovascular diseases, and osteoporosis. The cornerstone of recommended dietary… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a real-time ultrasound system for evaluating musculoskeletal soft tissue conditions by implementing the novel ultrasound post-processing software developed in Phase I into a programmable platform ultrasound system.… more
Abstract:ABSTRACT: An instrument measuring volume charges in thin dielectric films is proposed. The instrument utilizes an enhanced Pulsed Electro-Acoustic (PEA) technique and delivers submicron spatial and at least 0.1 micro-Coulombs per cubic centimeter resolutions of the charge density. Traditional PEA… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop and commercialize an integrated system to actively stabilize an optical microscope to the precision required by today's cutting-edge imaging methods. Microscopy in the biological sciences is undergoing radical… more
Abstract:Purpose: Prior research demonstrates that younger students who are low- or non-verbal often have difficulty independently practicing skills that provide a foundation for early literacy. The proposed product will provide support to students who are low- or non-verbal to independently practice phonics… more
Abstract:DESCRIPTION (provided by applicant): Patient socket performance is a critical barrier to progress in rehabilitation, the most common source of patient dissatisfaction and part of a growing medical and socioeconomic problem. Poor socket performance is a greatly uncharacterized multi-factorial… more
Abstract:DESCRIPTION (provided by applicant): Our companys' goal is to create and commercialize a modular, immediate fit, transtibial prosthesis system at a fraction of the cost of conventionally manufactured devices. Our product will be mass produced using the latest injection molding techniques with… more
Abstract:USDA secretary, Tom Vilsack, has urged the Forest to prioritize "protecting and maintaining all American Forests, including state and private lands. ... The Forest Service must play a significant role in the development of new markets and ensure their integrity." Small-diameter round… more
Abstract:We propose to design and implement a set of CAD queries by which to achieve model interchangeability in assemblies, model interoperability, and model integration for CAD/CAE. A model scenario will be used to illustrate how this can be accomplished. In Phase 1, we will establish the feasibility of… more
Abstract:DESCRIPTION (provided by applicant): Current NIGMS-SBIR funding supported InvivoSciences LLC's (IVS) launch of several product lines in 2010. IVS generated revenues from the sales of three-dimensional (3D) cell culture tools (MC-8TM and IVS InsertsTM) thatcan grow various hydrogel tissues… more
Abstract:Our company has several vaccine candidates that could help in protecting animals from Johne's disease. In this phase of the project, we will test the performance of these vaccines in mice. Once proven protective, we will be able to run more tests on a ruminant model of infection that pave the… more
Company:DAND FISH FARMAgency/Program/Year/Phase:USDA / SBIR / 2012 / 1
Abstract:Walleye are a highly valued foodfish and sportfish in the North Central region of the US. The overall goal of our project is to test the feasibility of combining selected new technologies for the commercial production of walleye for food fish and for advanced fingerlings for stocking. For foodfish… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is to provide a smoking-cessation intervention tool for health care providers in prenatal settings. Smoking during pregnancy is a significant public health issue. The prevalence of smoking in women of child-bearing age… more
Abstract:DESCRIPTION (provided by applicant): Xenotransplantation with pig organs offers the best near term hope for satisfying the limitation imposed by shortage of human organs. This research project is directed toward producing as a product a genetically modified pig that will be the best potential donor… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to demonstrate the feasibility of a system that allows for rapid detection and measurement of the concentration of metal ions in water with a view towards application of this system to monitoring water being released into… more
Abstract:This Small Business Innovation Research Phase I project explores the design and implementation of a robust and high-bandwidth audio-visual communication system between vehicles (especially, emergency vehicles such as police cars, firetrucks, and ambulances) and command and control centers. The core… more
Abstract:This Small Business Innovation Phase I project proposes to address the issue of end-of-life management of a family of bioplastics, specifically polylactic acid (PLA). The majority of products today manufactured from PLA are land filled or incinerated once reaching their end of life. Although PLA is… more
Abstract:ABSTRACT: Quantum-dot gain medium in semiconductor lasers exhibit higher resistance to radiation induced damage. Irradiated diode lasers comprising quantum-dot gain medium demonstrated lasing two orders of magnitude beyond the maximum dose sustainable by quantum-well semiconductor lasers. These… more
Abstract:DESCRIPTION (provided by applicant): A high-growth PR8 virus for pandemic vaccine production in ST6-Vero cells. In 2009, the traditional means of vaccine manufacturing for the H1N1 influenza pandemic failed to yield sufficient doses during the peak of thecrisis. A vaccine production method that can… more
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