Abstract:DESCRIPTION (provided by applicant): Workers in painting, automobile, textile, printing, and pharmaceutical industries are exposed to vapors from organic solvents that are recognized by National Institute of Occupational Safety and Hygiene (NIOSH) as carcinogens, reproductive hazards, and/or… more
Abstract:DESCRIPTION (provided by applicant): Primorigen Biosciences LLC SBIR Project Abstract Primorigen will use SBIR funds to develop and validate a microcarrier-based cell culture system for selection, scale-up and feeder-free mass production of iPS cells, based on Primorigen's proprietary… more
Abstract:The interplay between accurate modeling and well-diagnosed experiments plays a critical role in advancing our understanding of high energy density laboratory plasmas (HEDLPs). It is vital to have high-fidelity computational physics tools that have well-tested radiation physics modeling, and that are… more
Abstract:DESCRIPTION (provided by applicant): Complications arising from pathogen infection incur a tremendous societal cost both in morbidity and mortality (as high as 50-60%), as well as in care and treatment estimated in billions of dollars. In susceptible patients, infection induces mis-regulation of the… more
Abstract:Silatronix has developed novel organosilicon compounds that can be used as drop-in replacements for conventional carbonate electrolytes in lithium-ion cells. These organosilicon electrolytes have very high flash points and have demonstrated superior stability and safety characteristics. In the… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a high-throughput assay incorporating 3-D skin models capable of accurately identifying and characterizing DNA damage. There is an urgent need for improved genotoxicity assays for safety screening in drug development… more
Abstract:DESCRIPTION (provided by applicant): Chronic and infected wounds significantly affect the quality of life for millions of US citizens and are associated with increased risk of complications including the devastating consequence of amputation. As of 2006, infections of diabetic foot ulcers resulted… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Type 2 Competitive Renewal SBIR application to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct a phase I/II clinical trial to investigate the safety and earlyefficacy of a novel antimicrobial living… more
Abstract:In vitro skin models have shown excellent potential for the evaluation of acute skin irritation. However, the current systems lack the ability to discriminate between mild and strong irritants and require labor-intensive protocols that limit test throughput. To address the three critical limitations… more
Abstract:DESCRIPTION (provided by applicant): Over the last decade, bacterial and archaeal communities have been identified in virtually every ecological niche examined, from acid mine drainage to tropospheric clouds to the human body. Understanding the make-up andinteractions within these communities is… more
Abstract:ABSTRACT: ORBITEC proposes to develop and synthesize a safe, high performance, high density solid oxidizer to replace Ammonium Perchlorate (AP) in solid propellants for use in booster, tactical, and strategic systems. The long sought replacement for ammonium perchlorate remains an unanswered… more
Abstract:ABSTRACT: ORBITEC proposes to develop and demonstrate a family of Low-Cost Thrust Chambers (LCTC) for use in future NASA exploration systems. Substantial cost savings will be realized in the production of the LCTCs with ORBITEC"s innovative hybrid fabrication technique. Hybrid fabrication… more
Abstract:ORBITEC proposes to develop high strength cast aluminum alloys for use in Expeditionary Fighting Vehicle (EFV) structures. Using a new casting technique developed by MSOE, the cast alloys HPAC structures will achieve material properties similar to those of forged structures. The casting process is… more
Abstract:ORBITEC proposes to develop the Recoilless Launcher Propulsion System (RLPS), a means of propelling a warhead from a shoulder-mounted recoilless launcher which will greatly reduce the risks posed to the operator by the back blast from such launchers, including over-pressure, high sound levels, and… more
Abstract:ABSTRACT: ORBITEC proposes to demonstrate and validate a laboratory-scale experimental injector stability screening technique which will quantify injector element stability characteristics. The experimental approach promises to dramatically reduce development cost by utilizing a gaseous single… more
Abstract:C5-6 Technologies and University of Wisconsin Stevens Point scientists will develop a bacterial strain that economically ferments sugars into isoprene, a platform chemical that will play a central role in the future bio-economy. UWSP scientists have genetically engineered E. coli to produce isoprene… more
Abstract:DESCRIPTION (provided by applicant): Improved therapy has transformed cystic fibrosis (CF) from a disease characterized by death in early childhood to a chronic illness with a median survival of approximately 30 years. However, there is still no cure for this devastating genetic disease affecting… more
Abstract:The objective of this phase I STTR project is to develop and demonstrate a roll-to-roll process for printing semiconductor and metal nanostructures with lateral dimensions as small as 100 nm on flexible substrates. systeMech will collaborate with the University of Wisconsin-Madison (Prof. M.G.… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a novel software technology for practical clinical use that can evaluate dynamic ultrasound images to accurately interpret changes or pathologies in soft tissues, such as tendons and ligaments. Today, a radiologist… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to significantly advance H2 gas sensing technologies by exploring a novel nanohybrid sensing platform of SnO2 nanocrystals supported on carbon nanotubes (CNTs). The high demand of H2 as a clean energy source drives the fast growth… more
Abstract:This Small Business Innovation Research Phase I project targets multifunctional meta-materials having acoustic impedance equal to tissue and optimized for solid-state tactile sensing. Optimized multifunctional performance of these newly developed meta-materials includes enhanced mechanical, acoustic… more
Abstract:A bi-stable meta-material which rejects high amplitude harmful sound but transfers sound levels needed for the situation awareness is proposed. A threshold intensity of the sound is determined by the material design and is set to 90 dBA all signals exceeding this level will be attenuated at least… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is aimed at developing an integrated system to stabilize a conventional high-end, inverted optical microscope to the precision required to routinely achieve the imaging power of emerging super-resolution (SR) microscopy techniques. These… more
Abstract:This Small Business Innovation Research (SBIR) phase I aims to demonstrate the feasibility of constructing a novel machine for manufacturing low-cost glass-to-metal seals for insulating window glazing. Applications include vacuum glazing which insulates as well as a wall (R11 to R20), representing a… more
Abstract:Vacuum glazing requires a scratch-resistant Low-E coating. Microscopic pane spacers are required to prevent the two panes from touching under external pressure, but create high contact stresses which can scratch glass and existing Low-E coatings during pane movement with temperature change. Hard… more
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