Abstract:DESCRIPTION (provided by applicant): Cardiotoxicity, as a result of adverse drug effects, is a serious problem that has yet to be effectively screened prior to patient exposure. Cardiac safety is one of the leading causes of compound attrition in the pharmaceutical industry and withdrawal of… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to complete development of a universal, in vitro assay for determining the enzymatic activity of botulinum neurotoxin (BoNT)-based pharmaceuticals. This assay, called BoTest Matrix A Assay, will enable standardized comparisons… more
Abstract:Each week, in total, 338 small and mid-sized farms ($1,000-500,000 in revenue) go out of business despite the undeniable demand for local food. This proposal will work with a state department of agriculture to research the viability of real-time price sheet marketing, as compared to static… more
Abstract:DESCRIPTION (provided by applicant): The internet is an increasingly important resource for clinicians to access training materials and resources for treatment delivery of evidence-based treatments such as cognitive behavioral therapy (CBT) and antidepressant medications. This project proposes to… more
Abstract:DESCRIPTION (provided by applicant): More efficient methods to screen and monitor elderly patients in clinical practice and research are needed, but visits to clinical offices are expensive and many older patient are restricted by mobility or transportation access. The Alzheimer's Disease… more
Abstract:DESCRIPTION (provided by applicant): Contrast enhancement on MRI (magnetic resonance imaging) provides the best currently available approach for measuring tumor response to therapy in brain and other solid tumors. Accordingly, criteria have been formulated, by international committees, to guide the… more
Abstract:DESCRIPTION (provided by applicant): Modeling Professional Attitudes and Teaching Humanistic Communication in VR (MPathic-VR) Patients with life-threatening cancer need caregivers who can help them through difficult decisions by understanding their interests, values, and beliefs, and who… more
Abstract:DESCRIPTION (provided by applicant): Respiratory infections have a significant health and economic impact worldwide. Current test products for the diagnosis of respiratory viral infections such as influenza are inadequate for the timely diagnosis needed for successful implementation of antiviral… more
Abstract:DESCRIPTION (provided by applicant): 100,000 Americans perish each year due to untreatable bacterial infections. The societal benefits of new antibiotic compounds that are effective against numerous multiple drug resistant pathogens would be significant. The best possible source for new antibiotic… more
Abstract:DESCRIPTION (provided by applicant): A major goal in the post-genomic era is to express the vast collection of protein- coding sequences, eventually resulting in a better understanding of protein interactions and the development of novel therapeutics. Themost favored host for heterologous… more
Abstract:DESCRIPTION (provided by applicant): Each year, 100,000 Americans perish due to untreatable bacterial infections. The societal benefits of new antibiotic compounds that are effective against numerous multiple drug resistant pathogens would be significant.The best possible source for new antibiotic… more
Abstract:DESCRIPTION (provided by applicant): Robust expression of multi-subunit protein complexes is crucial for understanding the basic biology of organisms. Expression of the individual components in E. coli or yeast may be quick and cost-efficient, but many mammalian proteins show poor expression or… more
Abstract:DESCRIPTION (provided by applicant): Monoclonal antibodies (mAbs) have been developed into a highly effective class of therapeutic molecules, with global growth of 37% between 2001 and 2002. Since their discovery in 1975, mAbs have been described as magic bullets with the potential to seek out… more
Abstract:ABSTRACT: Study of non-stationary phenomena in turbulent combusting flows requires spatial measurements of a set of parameters at kHz rates. Ideally these parameters would include the velocity , temperature, and a relevant species concentration. In response to this need, ORBITEC and the… more
Abstract:ORBITEC's Non-Thermal Sanitation by Atmospheric Pressure Plasma technology sanitizes fresh fruits and vegetables without the use of consumable chemicals and without significantly raising the temperature of the food, so food taste and quality are not affected. Atmospheric pressure plasma is well… more
Abstract:ORBITEC proposes to develop and demonstrate a novel cooling concept called Lattice Regenerative Cooling Methods (LRCM) for future high thrust in-space propulsion systems. Incorporation of ORBITEC's innovative lattice structures in the fabrication of thrust chambers for expander cycle engine… more
Abstract:ORBITEC, in collaboration with Lucigen, proposes a rapid genetic detector for spaceflight water systems to enable real-time detection of E. coli with minimal consumables and crew time. The Rapid Coliform Detector (RCD) amplifies the genetic material in a liquid sample to allow near real-time… more
Abstract:ORBITEC proposes to develop non-toxic propulsion systems to replace hyradzine-derivative systems in interceptor applications. In ongoing work, ORBITEC has been developing high-performance ionic liquid fuels. These inherently non-volatile fuels promise safer, less sensitive systems while providing… more
Abstract:ABSTRACT: ORBITEC proposes to develop the Cooling Channel Diagnostic System (CCDS), a diagnostic tool for assessing the condition of rocket engine cooling channels. This system will be used to detect and locate any deposits which inhibit heat transfer between cooling channels and the hot-gas wall… more
Abstract:ABSTRACT: ORBITEC proposes to develop a hybrid cycle to improve the overall performance and reduce the cost of advanced upper stage engines. Upper stage engines using the High Performance Hybrid Cycle (HPHC) will have the benefits of compact design, high thrust-to-weight, and high Isp. Once… more
Abstract:ORBITEC proposes to develop the Advanced Reversible Cryogenic Thermal Energy Storage (ARCTES) system, which will provide temporary backup cooling for circulating helium gas coolant in high-temperature superconducting (HTS) systems for naval applications. The ARCTES will rely on an initially-frozen… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will lead to the development of a new class of liquid crystal (LC)-based direct-read monitors (DRMs) for detection of nitrogen dioxide (NO2) present in air at construction sites. The approach to development of DRMs that is described in… more
Abstract:DESCRIPTION (provided by applicant): Primorigen Biosciences SBIR Proposal Abstract Primorigen Biosciences will use SBIR funds to develop an advanced cell culturing methodology to increase the efficiency of directed differentiation and to boost functional maturity of induced pluripotent stem… more
Abstract:DESCRIPTION (provided by applicant): Primorigen Biosciences will develop an enhanced cell culturing technology that dramatically increases proliferative and differentiation capabilities of human bone-marrow derived mesenchymal stem cells (hMSC's) for neural induction, and ultimately for… more
Abstract:DESCRIPTION (provided by applicant): Schizophrenia is a chronic and debilitating disorder that impacts nearly 1% of the world's population. The burden on the families and caregivers of patients is immense, with the cost of care in the United States being greater than 60 billion annually. The… more
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