Abstract:Our company has several vaccine candidates that could help in protecting animals from Johne's disease. In this phase of the project, we will test the performance of these vaccines in mice. Once proven protective, we will be able to run more tests on a ruminant model of infection that pave the… more
Company:DAND FISH FARMAgency/Program/Year/Phase:USDA / SBIR / 2012 / 1
Abstract:Walleye are a highly valued foodfish and sportfish in the North Central region of the US. The overall goal of our project is to test the feasibility of combining selected new technologies for the commercial production of walleye for food fish and for advanced fingerlings for stocking. For foodfish… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is to provide a smoking-cessation intervention tool for health care providers in prenatal settings. Smoking during pregnancy is a significant public health issue. The prevalence of smoking in women of child-bearing age… more
Abstract:DESCRIPTION (provided by applicant): Xenotransplantation with pig organs offers the best near term hope for satisfying the limitation imposed by shortage of human organs. This research project is directed toward producing as a product a genetically modified pig that will be the best potential donor… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to demonstrate the feasibility of a system that allows for rapid detection and measurement of the concentration of metal ions in water with a view towards application of this system to monitoring water being released into… more
Abstract:This Small Business Innovation Research Phase I project explores the design and implementation of a robust and high-bandwidth audio-visual communication system between vehicles (especially, emergency vehicles such as police cars, firetrucks, and ambulances) and command and control centers. The core… more
Abstract:This Small Business Innovation Phase I project proposes to address the issue of end-of-life management of a family of bioplastics, specifically polylactic acid (PLA). The majority of products today manufactured from PLA are land filled or incinerated once reaching their end of life. Although PLA is… more
Abstract:ABSTRACT: Quantum-dot gain medium in semiconductor lasers exhibit higher resistance to radiation induced damage. Irradiated diode lasers comprising quantum-dot gain medium demonstrated lasing two orders of magnitude beyond the maximum dose sustainable by quantum-well semiconductor lasers. These… more
Abstract:DESCRIPTION (provided by applicant): A high-growth PR8 virus for pandemic vaccine production in ST6-Vero cells. In 2009, the traditional means of vaccine manufacturing for the H1N1 influenza pandemic failed to yield sufficient doses during the peak of thecrisis. A vaccine production method that can… more
Abstract:DESCRIPTION (provided by applicant): The health care burden associated with treatment of chronic and burn wounds amounts to more than 25 billion annually in the U.S., involving 8.6 million patients. One recent advance in wound care has been the development of biologic dressings that contain… more
Abstract:DESCRIPTION (provided by applicant): Magnetic Resonance Imaging (MRI) of the breast has some clear advantages over traditional breast imaging modalities (x-ray mammography and ultrasound). Breast MRI has been shown to be at least twice as sensitive as mammography or ultrasound in detection of breast… more
Abstract:DESCRIPTION (provided by applicant): Isomark LLC has developed a breath-based early detection technology (comprised of biomarkers and instruments for detection) that can pinpoint the onset of acute systemic inflammation. Isomark's breath biomarkers may provide an indicator of neonatal health.… more
Abstract:DESCRIPTION (provided by applicant): Cardiotoxicity, as a result of adverse drug effects, is a serious problem that has yet to be effectively screened prior to patient exposure. Cardiac safety is one of the leading causes of compound attrition in the pharmaceutical industry and withdrawal of… more
Abstract:The technical objectives of this proposal are: 1) the design of 3.8-4.2 micron-emitting, active-photonic-crystal (APC) quantum-cascade (QC) lasers by using passive phase-locking in a monolithic structure in order to achieve multiwatt-range, diffraction-limited powers; and 2) the development of the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will enhance learning gains among historically underachieving middle school students via a Physical Science game that aligns with a standards-based print curriculum and utilizes principles from the Universal Design for Learning (UDL)… more
Abstract:This Small Business Innovation Research Phase I project will investigate the feasibility of producing spider silk fibroins in plant trichomes. Synthetic spider silk has great potential as an environmentally-friendly biomaterial because it is very flexible yet has a tensile strength greater than… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to bring to market a hand-held probe used by the surgeon to ascertain that the surgical wound and regional lymph nodes are clear of cancer. This technology will provide a highly innovative, rapid and accurate device for detecting… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a novel, commercially-viable, hybrid system that improves the adhesion of nanocrsytalline diamond (NCD) coatings to tungsten carbide (WC) cutting tools. A new hybrid system will be assembled, tested, and optimized.… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project has the goal of creating a signal amplification system that, while being inexpensive and simple to use, can be combined with antibodies or other probe molecules, and can increase detection limits of conventional ELISAs by 100- to… more
Abstract:DESCRIPTION (provided by applicant): AquaMost is developing a water treatment device based on a technology called photoelectrocatalytic oxidation (PECO). The focus for this project is using PECO systems to treat groundwater contaminated with organic pollutants released from leaking underground… more
Abstract:DESCRIPTION (provided by applicant): Post translational modifications (PTMs) such as phosphorylation, glycosylation and methylation play a central and ubiquitous role in cellular signal transduction, and the enzymes that catalyze these reactions such as kinases and methyltransferases are the targets… more
Abstract:This Small Business Innovation Research Phase I project highlights a strategy for the development of the first integrated high throughput pipeline to synthesize and evaluate novel sugar-drug conjugates. The core innovation of this proposed phase I study is an enzyme catalyzed one-step glycosylation… more
Abstract:DESCRIPTION (provided by applicant): Non-small cell lung cancer (NSCLC) is among the most common and lethal cancers yet, the current standard of care for advanced stage NSCLC provides only modest improvements in overall survival or quality of life. Thus,there exists a significant unmet need for new… more
Abstract:DESCRIPTION (provided by applicant): Botulinum neurotoxins (BoNTs) are the most toxic substances known to humans, causing respiratory failure. Because of their lethality and ease of production, the Department of Defense (DoD) designates BoNTs as a categoryA bioterrorism agent. Developing effective,… more
Abstract:DESCRIPTION (provided by applicant): Botulinum neurotoxins (BoNT) are the most toxic substances known to humans, causing respiratory failure upon intoxication. Despite their lethality, BoNTs have clinical health and cosmetic applications and are currentlyFDA-approved for treating cervical dystonia,… more
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