Abstract:Primorigen Biosciences (R) Abstract Primorigen Biosciences will use SBIR funds to develop a high-throughput toxicology assay system utilizing human ventricular cardiomyocytes (vCMs) differentiated from human induced pluripotent stem cells (hiPSCs). Phase Istudies will convert the small-molecule… more
Abstract:Primorigen Biosciences (R) Abstract Primorigen Biosciences will use SBIR funds to develop a novel commercial assay that measures the toxicity of compounds on human induced pluripotent stem cells (hiPSCs) differentiating into hematopoietic progenitor cells(HPCs) and on HPCs differentiated from hiPSCs… more
Abstract:DESCRIPTION (provided by applicant): Primorigen will use SBIR SHIFT funds to develop an array system that can identify chemically-defined surfaces to optimize induced pluripotent stem cell (hiPSC) differentiation and maturation. The platform initially willbe validated for its capacty to help… more
Abstract:DESCRIPTION (provided by applicant): Primorigen Biosciences (R) Abstract Primorigen Biosciences will use Phase II SBIR funds to advance its novel, 3-dimensional system for robust expansion of induced pluripotent stem cells (iPSCs) by a) scaling up iPSC production in 3L bioreactors, b) validating the… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop functional magnetic resonance imaging (fMRI) tools to assist the diagnosis and treatment of human patients with a brain tumor or other operable pathology. The specific focus of this proposal is to produce a practical,… more
Abstract:DESCRIPTION (provided by applicant): The diagnosis and treatment of patients with brain tumors and other diseases is often critically dependent on functional neuroimaging (e.g. fMRI) to identify healthy brain tissue that must be avoided during invasive surgery or radiation treatment. But,… more
Abstract:In the proposed Phase II Enhancement, Prism Computational Sciences, Corvid Technologies, and Bodkin Design and Engineering will perform experimental and simulation studies of the optical emission from impact flash events. This collaboration builds on the SBIR Phase II efforts of the Prism-Corvid… more
Abstract:DESCRIPTION (provided by applicant): This application aims to test a new Scarab E. coli strain, MDS42pdu, for commercial fermentation to produce biopharmaceuticals, amino acids and biofuels. It is designed for a very low rate of point mutations and Insertion Sequence transposition, especially in the… more
Abstract:DESCRIPTION (provided by applicant): Biotherapeutics is a fast-growth sector in the pharmaceutical market with monoclonal antibodies accounting for almost 50% of the 100 billion USD spent each year on protein therapies. Bacterial fermentation, which accounts for about 35% of all protein therapeutics… more
Abstract:Complex skin defects, including burns and trauma, represent a major medical problem affecting both military and civilian populations. In recent military engagements, burns account for approximately 5% of combat casualties. Furthermore, approximately 1.25 million Americans each year require medical… more
Abstract:DESCRIPTION (provided by applicant): The scientific literacy of U.S. high school students is disturbingly low, leaving many ill-prepared to comprehend the substance of important modern issues, as well as their own health-related conditions. Enhanced educational efforts are needed to improve the… more
Abstract:Many detectors - including solid-state particle detectors, microchannel plates, and photodiodes - output small current signals that require amplification and conversion to a voltage. Current-to-voltage converters (I/Vs) are widely utilized in experimental and commercial applications for this task.… more
Abstract:DESCRIPTION (provided by applicant): Remarkable improvements in throughput, accuracy and cost-effectiveness of next-generation sequencing (next-gen) technologies are ushering in a new era of clinical medicine. Genome wide association studies (GWAS) in particular have begun to leverage these advances… more
Abstract:Convincing scientific evidence provides the association between dietary choices and chronic disease expression. Dietary guidelines now in place are designed to prevent the onset of such chronic diseases as tissue-specific cancers, cardiovascular diseases, and osteoporosis. The cornerstone of… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project will develop a facultative anaerobic bacterium that ferments sugars obtained from cellulosic sources into isoprene, a valuable feedstock used in the production of latex rubber, plastics, and pharmaceuticals. Isoprene also is used for the… more
Abstract:Vacuum glazing has been on the market for over a decade, but its performance is poor, and its cost too high for wide adoption. Both issues stem from the use of a hard glass edge seal, which requires a high temperature manufacturing process, and which does not flex to accommodate outer pane… more
Abstract:Obesity is a growing epidemic that threatens the health of both adults and children. The problem is exacerbated by challenging economic times and increasing food costs that put pressure on consumers to purchase lower priced meals, which may be of inferior nutritional value and/or contain excessive… more
Abstract:The desire and benefit to improve the environment through the use of advanced electric drive vehicles is hampered by the high cost and associated manufacturing hazards associated with the manufacture of lithium ion batteries. The use of solvents in the lithium ion battery manufacturing process… more
Abstract:We propose to design and implement a query-based approach to interoperable modeling and simulation of composite material structures, that usually contain the manufacturing recipe within their design. In Phase I, we established the feasibility of the approach using a demonstration scenario of CAD/CAE… more
Abstract:Johne & #39;s disease (JD) or paratuberculosis in animals (infection with M. avium ss. paratuberculosis, M. ap) is a contagious, chronic, and potentially fatal disease affecting the small intestine of ruminants. All ruminants are susceptible, but the largest economic impact is felt in dairy… more
Abstract:DESCRIPTION (provided by applicant): Evaluation of dental tobacco cessation tool in practice-based research network This Phase II project will finish development and evaluate QuitAdvisorDDS as a tool for dental providers to advise patients on tobacco cessation. The University of Kentucky will… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop robust manufacturing methods to commercialize novel biobased plastics made from scrap PLA resins, resulting in a new method to effectively address end-of-life management of bioplastics, specifically polylactic acid (PLA).… more
Abstract:This Small Business Innovation Phase I project proposes to develop technology and products that will eliminate the use of polyvinylchloride (PVC) in one of its largest volume uses, flooring materials. Interfacial Solutions has recently demonstrated that a high volume low cost plastic waste stream… more
Abstract:DESCRIPTION (provided by applicant): Implementation of evidence-based prescriptive exercise practices in rehabilitation therapy demands an objective muscular strength assessment method that is fast, reliable, portable, cost effective, and kinetic (i.e., able to test the full rnge of motion). It… more
Abstract:Flexible electronic and optical devices, including sensors/detectors, waveguides, and photonic crystal structures, have significant promise for improving communication and information processing capabilities in a number of military and commercial applications. However, the development of such… more
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