Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop novel superparamagnetic biocompatible cell-penetrant bioactive nanoparticles for reprogramming human somatic cells and generation of pluripotent stem cells with intact genomes. To demonstrate technical feasibility,… more
Abstract:The use of Biodiesel in the U.S. is presently hampered by a lack of suitable feedstocks that do not compete with the food industry. The original biodiesel feedstock was food grade soybean oil, and became a significant problem: 1) politically, because of the impact on food pricing and 2) economically… more
Abstract:This proposal's primary technical objective is to develop core mateials, to build and test a high temperature manufacturing and engineering demonstration article using inVision's cellular core technology, and to fulfill the solicitations specific objectives of proposing full scale concepts… more
Abstract:In order to improve situational awareness in high-density urban areas and complex terrains where threats can come from different elevations, three-dimensional mapping and visualization systems could prove to be very effective. Building systems that can integrate dense, live sensor data with existing… more
Abstract:Spatial Cognition, LLC is nearing the completion of work on Phase I research and development effort entitled"Immersive Vision, Data Fusion and Threat Awareness for Enhanced Sensor-to-Shooter Engagement/Targeting". The major goal of this effort is to leverage advances in sensor technology,… more
Abstract:DESCRIPTION (provided by applicant): Autodissemination is a novel technique for insect control whereby target insects spread insecticide to their own habitats through their innate behaviors: a small treatment area results in far wider and target-specific coverage. This concept shows high potential… more
Abstract:DESCRIPTION (provided by applicant): Each year, an estimated 1.7 million patients in the U.S. experience a hospital infection (CDC). Approximately 750,000 of these infections lead to severe sepsis, with over 200,000 patients dying . As a result, 16 billion (40% of all intensive care unit… more
Abstract:DESCRIPTION (provided by applicant): Approximately 22 million people in the US suffer from asthma (National Heart, Lung, and Blood Institute). As a result, the annual economic cost of asthma is 19.7 billion. Globally, an estimated 300 million people worldwide have asthma, with 250,000 annual deaths… more
Abstract:DESCRIPTION (provided by applicant): There is an urgent need for novel therapies to treat malignant astrocytomas, the most common and aggressive primary tumor of the nervous system. Using current standard of care, patients diagnosed with these tumors havean average life expectancy of 18 months and… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase 1 SBIR application is to identify and structurally characterize compounds in chocolate that could be used to treat tissue inflammation associated with gingivitis and periodontitis. Previous studies have demonstrated that water soluble… more
Abstract:DESCRIPTION (provided by applicant): Magnetic beads have gained increasing use as a convenient separation technique for many forms of cell, nucleic acid and protein isolations and analyses. In particular, the manufacturers of clinical immunoassays utilizemagnetic beads both as a solid support for… more
Abstract:DESCRIPTION (provided by applicant): Conducting and completing clinical trials relies on successful recruitment of enough patient volunteers, who are appropriate matches, for any given study. Corengi, Inc. has developed a technology platform that supportsa dedicated website with a matching engine… more
Abstract:ABSTRACT: We propose to develop and validate (in phase I) detailed designs for highly scaled silicon photonic-electronic chips for applications relevant to the DOD in high-bandwidth data communication. This effort will be closely coordinated with the OPSIS (Optoelectronic Systems Integration in… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a method to objectively measure immune reconstitution following hematopoietic stem cell transplantation using direct sequencing of the T-cell repertoire. This method willbe developed using data from patients treated… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will extend the development of the contact-lens-enabled virtual reality display system demonstrated in Phase I. A key goal will be to advance the construction of the contact lenses to be ready for commercial market tests and OEM partner… more
Abstract:This Phase I project will demonstrate the feasibility of using specially modified contact lenses combined with an LCD display illuminated with a wave-guided backlight to enable an 80 degree field of view see-through display. The new eyewear architecture being proposed is a radical departure from… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on the design of a robust and low-cost enzyme immobilization system to increase the cost-competitiveness of bio-catalytic processes. The lack of a universal, sound, and affordable enzyme immobilization technique has been a large… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on the development of a high-yield fermentation route for the production of levulinic acid (LA). LA is one of the best-suited C5 building blocks for bio-refinery production due to higher value, broad applications, and likely… more
Abstract:DESCRIPTION (provided by applicant): PSMA is an important biomarker for prostate cancer prognosis and an appropriate target for therapy due to its restricted expression mainly on late-stage, androgen-independent and metastatic prostate cancer cells. Whilecurrently there is only one clinical PSMA… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to demonstrate the extraordinary performance of zwitterionic technology in protein interaction analysis. Zwitterionic polycarboxybetaine (pCB) is not only highly resistant to nonspecific protein adsorption, but also has abundant… more
Abstract:The overall objective of this SBIR is to provide the Sea Base, i.e., a flotilla of ships that may be holding station or slowly transiting an area, with a complete systems concept for a quick-to-establish, low-maintenance, durable system of temporary breakwater. Such a floating breakwater is to… more
Abstract:Researchers are currently hindered from observing dynamic gas-solid interactions in the transmission electron microscope (TEM). Yet, solid-state materials and gases interact in many important ways. The most critical technological application for these observations is catalysis, where one would like… more
Abstract:The primary experimental method used to determine the local internal structure of materials is that of transmission electron microscopy (TEM). If one also subjects the sample to an excursion in temperature during imaging at high resolution, one can watch the material processes involved in structural… more
Abstract:Wildlife Computers presents a remote release device for use with marine mammal data-logging tags proposed with three variations to suit cetaceans and large and small pinnipeds. The device uses innovative approaches such as ElectRelease epoxy for the releasing mechanism and an Argos-based signaling… more
Abstract:The motivation for this research project is to develop nanocomposite material for biomimetic bone repair material that meets all the requirements of solicitation N102-179. This project will provide the means to produce an advanced composite of materials with known efficacy to leverage the mechanical… more
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