Abstract:DESCRIPTION (provided by applicant): The current SBIR Phase I proposal addresses a need for the rapid and simple sample preparation of genomic DNA from human saliva and blood through a novel technology: microscale tip enrichment probes that employ electric fields and capillary action. With the… more
Abstract:To realize laser-driven inertial fusion energy with economically viable efficiency and repetition rates, pumping the laser system with semiconductor diode lasers instead of the flashlamp will be essential. Diode laser prices are currently much too high for practical implementation of fusion energy.… more
Abstract:nLight proposes to suppress the key remaining output power extraction limiter COMD failure mechanism by passivating the cleaved facet of laser diodes with high bandgap semiconductor layers that is epitaxially grown in an atomically conformal manner at low temperature and in ultra-high vacuum.
Abstract:nLight proposes a novel semiconductor laser device operating at ~976 nm with a spatially single mode laser that is separately addressable to generate a few hundred milliwatts of power and then subsequently amplified to>10 watts with a separate electrical contact in a larger gain area while… more
Abstract:Higher power wavelength-stabilized pump sources operating in the 78x-nm to 79xnm band are expected to enable high-energy CW laser systems based on low pressure alkali gasses (such as Cs or Rb). Under the proposed program, nLight will design, demonstrate, and deliver to the MDA (or recipient of their… more
Abstract:Improving efficiency as well as increasing operating temperature of laser diode pumps for high-power fiber lasers has a far-reaching implication in terms of significantly improving the overall stringent size, weight and power (SWAP) requirements, thus enabling DEW-class fiber lasers on airborne… more
Abstract:nLight proposes to develop and commercialize an innovative kilo-watt class fiber laser pump combiner which is especially suited for counter-pumping architectures that is indispensable for various coherent combining techniques. The key advantages of this proposed technology over the current… more
Abstract:nLIGHT will develop a novel fused fiber combiner capable of accepting standard-sized active fibers. This"over-sleeve"combiner is designed to leave the active fiber undisturbed, allowing for counter propagation pumping of the laser amplifier, while efficiently coupling multiple kilowatts of… more
Abstract:It is well known that satellite communications and radar signals propagating in the natural ionosphere can be disturbed. It has also been widely reported that the ionosphere is subject to even greater disturbances following nuclear detonations. Hence the design of robust satellite communications… more
Abstract:UHF radars at high latitude observe significant perturbations in measurements of amplitude, phase, range, and Doppler, caused by ionospheric disturbances. Without mitigation of these effects, there is no doubt that the natural ionosphere is a major issue in the performance of the important radar… more
Abstract:ABSTRACT: Coordinate Registration (CR) of OTHR targets requires accurate real-time ionospheric modeling coupled with HF propagation calculations to convert radar-measured target signal delays and beam steers to geographical position. Our team is the developer of the most sophisticated CR… more
Abstract:DESCRIPTION (provided by applicant): Pain affects over 100 million Americans annually. Opioids are the primary drugs that can treat pain. However, these drugs produce severe and unwanted side effects, such as respiratory depression, nausea, constipation and tolerance development (Berde et al, 2008);… more
Abstract:DESCRIPTION (provided by applicant): Monoclonal Antibodies for Orphan GPCRs in the CNS GPCRs comprise a large family of structurally related membrane proteins with critical functions in neurobiology. As such, they are key therapeutic targets. However, many members of the vast GPCR family remain… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of the MASP-2 program is to develop a monoclonal antibody that blocks the function of MASP-2, in order to treat microvascular complications associated with diabetes. The goal of the work proposed in this application is to validate… more
Abstract:An efficient acoustic holography technique for characterizing the noise source of tactical aircraft jet plumes was developed through the bench testing stage in Phase I. A full-scale array of 100 microphone locations was designed to be able to capture the noise of an F-18 in a simulated carrier… more
Abstract:Refractory alloys such as tantalum-tungsten and ceramics are being pursued as a solution to high temperature erosive wear of gun barrels. However rifling of these materials with conventional broaching and electrochemical milling is proving to be difficult. This proposal seeks to demonstrate an… more
Abstract:Electroplated hard chrome is used extensively for aerospace and industrial applications because it is wear resistant, corrosion resistant, has a good surface finish and has good adhesion. Naval aircraft use chrome plating on landing gear components because of these characteristics. However these… more
Abstract:Aging aircraft experience fatigue cracking from stress concentrations around rivet holes. Current best practice is to pull an oversized mandrel through a split sleeve in the hole to induce beneficial residual compressive stresses and this improves fatigue life significantly. However, the benefit is… more
Abstract:Orora Design Technologies, Inc. proposes to develop an innovative computer-aided design (CAD) based methodology and enabling tools for rapid radiation-hardened prototyping and migration of military satellite microelectronics. A key innovative tool to be explored is automated generation and… more
Abstract:The goal of this research is to develop electronic design automation (EDA) tools to automate the following three major radiation-hardened-by-design (RHBD) tasks: (1) The capture of RHBD design constraints and design rules for sub-90nm mixed-signal designs in an industry-standard EDA data base, … more
Abstract:DESCRIPTION (provided by applicant): Lyso, a metalloendopeptidase that is bacteriolytic for S. aureus, is a potential systemic therapy for treating methicillin-resistant S. aureus (MRSA) mediated infections including endocarditis, osteomyelitis, catheter related infections, and MRSA-mediated… more
Abstract:DESCRIPTION (provided by applicant): Psoriasis is a chronic inflammatory skin disease that to this date is only insufficiently controlled by currently available treatments which can also come with severe, and sometimes life threatening side effects. In this application, we propose to create a new… more
Abstract:Many fungal and bacterial pathogens produce proteolytic enzymes that facilitate penetration into fish skin or eggshells. These diseases are a major and growing challenge to sustainable aquaculture in the United States. Our Phase I research results demonstrated the feasibility of new, non-toxic,… more
Abstract:This SBIR program will develop a lightweight, high performance ceramic matrix composite thruster for DACS propulsion. The Phase I program will identify the sealing and joining materials, and demonstrate the processes that are suited for construction of advanced ceramic matrix composite (CMC)… more
Abstract:Laser wakefield acceleration (LWFA) has demonstrated the ability to accelerate electrons in a plasma with gradients & gt;30 GeV/m where a capillary discharge is used as the plasma source. The capillary discharge has a parabolic plasma density profile that is able to guide the focused laser beam… more
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