Abstract:DESCRIPTION (provided by applicant): Molecularly Engineered Biomaterials for Minimally Invasive Dental Treatment Molecularly-engineered biomaterials are an ideal candidate for minimally invasive dental preparations, caries removal, and other dental treatments, including cleaning in perigingival… more
Abstract:ABSTRACT: Modern military space systems use high specific impulse (Isp) propulsion systems to provide efficient station keeping and large delta-V orbital maneuvers. A multi-mode propulsion system utilizes a single propellant such as AF-M315E to provide high thrust as well as a 1000-4000 s Isp. By… more
Abstract:Ocean wave energy has the potential to support approximately 10% of domestic and global electricity demand. Despite considerable investment over the past decade, however, wave energy is unlikely to make a material contribution to domestic or global energy supplies unless new technologies with… more
Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR builds upon the activities of R43-AT006634, VerOFy: A New Tool to Improve Productivity and Reduce Costs for Stress Research . Technology for an integrated sample collection system was developed whichnon-invasively measures salivary cortisol… more
Abstract:DESCRIPTION (provided by applicant): A safe and effective therapeutic for treatment of osteoarthritis (OA) represents a major unmet medical need. OA is the leading cause of disability in the US and pain is a predominant clinical feature. However, chronicuse of non-steroidal anti-inflammatory drugs… more
Abstract:DESCRIPTION (provided by applicant): To gain a comprehensive understanding of cellular structures and function, correlative light and electron microscopy has been widely utilized to facilitate the acquisition of both macroscopic view of the whole organismand the localization of single molecules or… more
Abstract:DESCRIPTION (provided by applicant): Each year over 2 million adolescents are arrested in the U.S., and many more (9-18 percent of all youth) engage in serious delinquent behavior, such as heavy drinking, illicit drug use, and school drop-out. The most effective interventions to address these… more
Abstract:DESCRIPTION (provided by applicant): In the proposed phase II NIH STTR funding opportunity (PA-12-089), LodeSpin Labs (LSL) is developing a magnetic nanoparticle tracer for use in Magnetic Particle Imaging (MPI), a disruptive new medical imaging technologycurrently being developed as a safe,… more
Abstract:DESCRIPTION (provided by applicant): With few exceptions, extensive characterization of signal pathway alterations in cancer, and advances in our capacity to identify potent modulators of distinct molecular targets, has not translated into breakthrough drugs. In a recent New York Times article (Nov.… more
Abstract:Sample return missions, by nature, require high levels of spacecraft autonomy. Developments in hardware avionics have led to more capable real-time onboard computing platforms, which allow for the implementation of more sophisticated algorithms. A real-time convex optimizer named COARSE (Convex… more
Abstract:If the energy resolution of electron energy loss spectroscopy (EELS) carried out in a scanning transmission electron microscope (STEM), with an atom-sized electron probe, could be improved to 10 meV or better, a new way of studying materials at the atomic scale, by recording and analyzing their… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop a high--?]throughput --?] surface acoustic wave nebulization (HTP--?]SAWN) ion source for mass spectrometry (MS). The SAWN ion source developed during phase I resulted in a device that has competitive performance between… more
Abstract:This Small Business Innovation Research Phase I project will focus on the development of ceramic nanosheets with structurally different sides (sticky/slick), which will be used to form a self-generating tribological coating for improved lubrication. This coating will be automatically created during… more
Abstract:DESCRIPTION (provided by applicant): Magnetic beads have gained increasing use as a convenient separation technique for many forms of cell, nucleic acid and protein isolations and analyses. In particular, the manufacturers of clinical immunoassays utilizemagnetic beads both as a solid support for… more
Abstract:The innovation evaluates the feasibility of developing a tablet-based suite of applications that allow students to interrogate relationships between molecular sequences, molecular structures, and their biological functions. One of the most difficult concepts for students to understand is why certain… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project is focused on the reuse of waste glass to generate high-value replacements for traditional masonry products. Masonry manufacturers cannot meet the construction industry's needs with their status quo product and are therefore losing… more
Abstract:The current method for monitoring hexavalent chromium in groundwater at environmental legacy sites is labor intensive, costly and does not allow for continuous in situ monitoring. The research project is developing an affordable, sensitive, durable and low-maintenance in situ sensor capable of… more
Abstract:The Navy needs a metal cutting system for submarine and aircraft carrier hull disposal. We propose to develop a Hull Cutting Mill (HCM) to meet Navy needs. Our HCM uses a compact high-speed high-power hydraulic milling head to perform slot-milling and achieve a fast lineal speed cutting high-tensile… more
Abstract:ABSTRACT: We propose to develop for the Air Force a high-efficiency Waste Heat Removal System (WHRS) that removes large amounts of waste heat from aircraft with negligible impacts on signature and aerodynamic performance. Our WHRS absorbs heat from aircraft thermal loads, including a Thermal… more
Abstract:This Small Business Innovation Research Phase I project seeks to greatly improve the light output of white-light light-emitting diodes (LEDs) using fluorescent nanoparticles or quantum dots (QDs) made from silicon. The most efficient and economical design for a contemporary white LED is based on a… more
Abstract:DESCRIPTION (provided by applicant): Schistosomiasis is a major neglected tropical disease of public health concern to a billion people with 200 million currently infected and 779 million at risk to acquire the infection, the majority of these in Africa.The disease has a high impact on affected… more
Abstract:DESCRIPTION (provided by applicant): Funding of this application will move a new combination cancer therapy for leukemia and lymphomas towards human clinical trials. Monoclonal antibodies, mAbs have emerged as a rapidly growing class of oncology therapeutics. Despite their success in certain… more
Abstract:Develop an inexpensive, easy to use, aerosolized delivery system of a combination of anti-tubercular drugs that could be used for the treatment of multi-drug resistant tuberculosis (MDR TB ). PUBLIC HEALTH RELEVANCE
Abstract:DESCRIPTION (provided by applicant): Based on the poor performance of fourth grade students on national and international tests of mathematics, it is evident students in the early grades are not adequately prepared in mathematics. Several researchers havedemonstrated that students who complete… more
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