Abstract:nLIGHT will develop a novel fused fiber combiner capable of accepting standard-sized active fibers. This"over-sleeve"combiner is designed to leave the active fiber undisturbed, allowing for counter propagation pumping of the laser amplifier, while efficiently coupling multiple kilowatts of… more
Abstract:It is well known that satellite communications and radar signals propagating in the natural ionosphere can be disturbed. It has also been widely reported that the ionosphere is subject to even greater disturbances following nuclear detonations. Hence the design of robust satellite communications… more
Abstract:UHF radars at high latitude observe significant perturbations in measurements of amplitude, phase, range, and Doppler, caused by ionospheric disturbances. Without mitigation of these effects, there is no doubt that the natural ionosphere is a major issue in the performance of the important radar… more
Abstract:ABSTRACT: Coordinate Registration (CR) of OTHR targets requires accurate real-time ionospheric modeling coupled with HF propagation calculations to convert radar-measured target signal delays and beam steers to geographical position. Our team is the developer of the most sophisticated CR… more
Abstract:DESCRIPTION (provided by applicant): Pain affects over 100 million Americans annually. Opioids are the primary drugs that can treat pain. However, these drugs produce severe and unwanted side effects, such as respiratory depression, nausea, constipation and tolerance development (Berde et al, 2008);… more
Abstract:DESCRIPTION (provided by applicant): Monoclonal Antibodies for Orphan GPCRs in the CNS GPCRs comprise a large family of structurally related membrane proteins with critical functions in neurobiology. As such, they are key therapeutic targets. However, many members of the vast GPCR family remain… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of the MASP-2 program is to develop a monoclonal antibody that blocks the function of MASP-2, in order to treat microvascular complications associated with diabetes. The goal of the work proposed in this application is to validate… more
Abstract:An efficient acoustic holography technique for characterizing the noise source of tactical aircraft jet plumes was developed through the bench testing stage in Phase I. A full-scale array of 100 microphone locations was designed to be able to capture the noise of an F-18 in a simulated carrier… more
Abstract:Refractory alloys such as tantalum-tungsten and ceramics are being pursued as a solution to high temperature erosive wear of gun barrels. However rifling of these materials with conventional broaching and electrochemical milling is proving to be difficult. This proposal seeks to demonstrate an… more
Abstract:Electroplated hard chrome is used extensively for aerospace and industrial applications because it is wear resistant, corrosion resistant, has a good surface finish and has good adhesion. Naval aircraft use chrome plating on landing gear components because of these characteristics. However these… more
Abstract:Aging aircraft experience fatigue cracking from stress concentrations around rivet holes. Current best practice is to pull an oversized mandrel through a split sleeve in the hole to induce beneficial residual compressive stresses and this improves fatigue life significantly. However, the benefit is… more
Abstract:Orora Design Technologies, Inc. proposes to develop an innovative computer-aided design (CAD) based methodology and enabling tools for rapid radiation-hardened prototyping and migration of military satellite microelectronics. A key innovative tool to be explored is automated generation and… more
Abstract:The goal of this research is to develop electronic design automation (EDA) tools to automate the following three major radiation-hardened-by-design (RHBD) tasks: (1) The capture of RHBD design constraints and design rules for sub-90nm mixed-signal designs in an industry-standard EDA data base, … more
Abstract:DESCRIPTION (provided by applicant): Lyso, a metalloendopeptidase that is bacteriolytic for S. aureus, is a potential systemic therapy for treating methicillin-resistant S. aureus (MRSA) mediated infections including endocarditis, osteomyelitis, catheter related infections, and MRSA-mediated… more
Abstract:DESCRIPTION (provided by applicant): Psoriasis is a chronic inflammatory skin disease that to this date is only insufficiently controlled by currently available treatments which can also come with severe, and sometimes life threatening side effects. In this application, we propose to create a new… more
Abstract:Many fungal and bacterial pathogens produce proteolytic enzymes that facilitate penetration into fish skin or eggshells. These diseases are a major and growing challenge to sustainable aquaculture in the United States. Our Phase I research results demonstrated the feasibility of new, non-toxic,… more
Abstract:This SBIR program will develop a lightweight, high performance ceramic matrix composite thruster for DACS propulsion. The Phase I program will identify the sealing and joining materials, and demonstrate the processes that are suited for construction of advanced ceramic matrix composite (CMC)… more
Abstract:Laser wakefield acceleration (LWFA) has demonstrated the ability to accelerate electrons in a plasma with gradients & gt;30 GeV/m where a capillary discharge is used as the plasma source. The capillary discharge has a parabolic plasma density profile that is able to guide the focused laser beam… more
Abstract:DESCRIPTION (provided by applicant): Tramadol is a widely prescribed analgesic, with over 25 million prescriptions and 565 million in retail sales in 2009, making it among the best selling generic drugs. One of the advantages of tramadol over traditionalopioids is its lower risk of opioid… more
Abstract:Systima is developing a high performance 25 lbf DACS thruster that operates with a novel non-toxic monopropellant. The monopropellant has a 30% higher density-specific impulse compared to hydrazine and is commercially available off-the-shelf. In Phase I Systima will focus on development of the… more
Abstract:Systima is developing an IM compliant High Performance Green Propellant (HPGP) DACS thruster that operates with a novel non-toxic monopropellant. The monopropellant has a 30% higher density-specific impulse compared to hydrazine, insensitive/ not a detonation hazard, and is commercially available… more
Abstract:Systima Technologies, Inc. (Systima) is proposing to develop an end-to-end integrated All-Up-Round (AUR) canister solution to provide a multiple missile launcher (MML) for Extended Area Protection & Survivability (EAPS) missiles. By allowing a single MML-AUR to provide multiple EAPS missiles the… more
Abstract:DESCRIPTION (provided by applicant): Primary Care Providers (PCPs) have the opportunity to identify and intervene with alcohol abusers and risky users at an early stage, preventing many negative health and societal consequences. Screening and brief intervention (SBI) for substance use problems is an… more
Abstract:DESCRIPTION (provided by applicant): Approximately one-third of those who turned 65 in 2010 will enter a nursing home for short or long-term stay in their lifetime. Although the older adult population is growing more diverse, the current population of nursing home residents is 86% White and 62%… more
Abstract:DESCRIPTION (provided by applicant): Modifiable behavioral risk factors for diabetes and cardiovascular disease, two of the most costly diseases in both human and monetary terms, include obesity, lack of physical activity, smoking tobacco and excess alcohol consumption. Despite a longstanding… more
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