Abstract:This project will develop high performance sealing plugs for use in deep borehole disposal of nuclear waste and commercial wells. The technology provides a high strength, high corrosion resistant well sealing material superior to conventional cements.
Abstract:Observing solid-liquid interfaces with high resolution is important for comprehension of physical, chemical, and biological interactions between material and fluid. A more detailed knowledge of these interactions can substantially improve our understanding of the processes that occur during… more
Abstract:The inability to dynamically image materials at atomic resolution in changing liquid environments is a significant impediment to the advancement of physical, chemical, biological, medical, and material sciences. Hummingbird Scientific, via its liquid cell holders, has greatly enhanced the ability… more
Abstract:Cryogenic soft X-ray detectors are enabling new analytical capabilities for science, engineering, materials characterization, and time-resolved studies. X-ray microcalorimeter detectors are increasingly being used at synchrotron light sources, with scanning electron microscopes and other analytical… more
Abstract:ABSTRACT: Systima Technologies, Inc. has developed a novel aerodynamic decelerator concept and technical approach for tailoring sounding rocket trajectories. Systima"s decelerator technology will broaden the performance range that a booster stack can achieve in order to deliver a hypersonic… more
Abstract:ABSTRACT: The current (such as the F-35) and the next (i.e. the 6th gen) generation of attack aircraft have a fundamental constraint. To achieve low radar cross-sections, they need to carry their weapons internal to the aircraft. This creates a conflict between the size and number of weapons that… more
Abstract:ABSTRACT: Systima Technologies will develop an ultra-low profile, modular carriage/release system by incorporation of various emerging technologies within the Munition Design. This system will nearly double carriage density compared to traditional bomb rack integrations (for 7"stores). By… more
Abstract:In the proposed program Systima Technologies Inc. will develop a tunable ETIVS thermal trigger device for integration into a TIVS on Navy weapon system platforms. Systima"s ETIVS trigger technology leverages Systima"s existing thermal sensing technology and expertise in design of devices… more
Abstract:DESCRIPTION (provided by applicant): Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling T-cell neoplasms are generally more aggressive and have poorer outcomes than comparable B-cell lymphomas. In addition, for many of these patients, prognosis following disease relapse is… more
Abstract:DESCRIPTION (provided by applicant): Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA-matched sibling or unrelated donor. Transplants using stem cells from umbilical cord blood provide an alternative for these patients, allowing… more
Abstract:Immunotherapy has emerged as a promising method to treat several cancers. In 2012 the FDA approved a new immunotherapy agent, ipilimumab, for metastatic melanoma. Ipilimumab activates T-cells and globally increases the adaptive immune response and resultsin an enhanced response to the cancer. In a… more
Abstract:This Small Business Innovation Research Phase II project focuses on the development of a high-yield fermentation route for the production of levulinic acid (LA). LA is one of the best-suited C5 building blocks for bio-refinery production due to higher value, broad applications, and likely quick… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project brings together computational enzyme design with systems biology to create a fully integrated platform for novel pathway designs. The approach chosen will combine specific databases and a novel pathway synthesis tool. This computational… more
Abstract:DESCRIPTION (provided by applicant): Allergy is a major cause of illness and disability with an estimated 40-50 million people afflicted in the US alone. AIT provides long-term benefits for the patient and its need for optimization creates a compelling business opportunity. There is a very strong… more
Abstract:Monitoring mercury contamination in groundwater, surface water, and other natural environments is challenging and expensive, and because samples have to be collected in the field and analyzed in a laboratory, there is a long delay before results are available. The expense of monitoring limits the… more
Abstract:In modern fusion concepts, inductive pickup loops are one of the primary magnetic diagnostics in tokamaks and small-scale concept exploration experiments. They are used in industries and laboratories that utilize and study low-temperature plasmas. Inductive pickup loops are capable of extremely… more
Abstract:Methods to reduce the turbulent viscous skin friction stand out as paramount to increasing the energy efficiency, and therefore the aerodynamic efficiency of supersonic aircraft. Eagle Harbor Technology (EHT) proposes to develop and optimize a MHD plasma injector, which will be used to efficiently… more
Abstract:Combustion of biomass, especially in small-scale applications, produces high emissions of particulate matter (PM) that have been linked to adverse health effects and global climate change. Current industrial particulate control solutions are prohibitively expensive for use in small scale biomass… more
Abstract:EOSPACE proposes developing a practical, very-wide-bandwidth electrical characterization technique based on advanced photonic signal processing. The characterization method only requires a high-speed mm-wave source and uses exclusively low-speed optical detection, eliminating the need for high-speed… more
Abstract:The objective is to develop a wideband, high-sensitivity, high RF power handling optical modulator suitable for use in low-noise microwave photonic links associated with military and commercial antenna applications. Specifically, the modulator will be designed to be highly-resistive to… more
Abstract:DESCRIPTION (provided by applicant): Treating patients infected with Human Immunodeficiency Virus-1 (HIV-1) is a substantial clinical challenge with evolving pharmaceutical drug and dosing options. Treatments should improve the health and quality of life for HIV-infected individuals by reducing… more
Abstract:Inexpensive biofuels are essential to the national economic and environmental stability of the United States. Pathways are well established to ferment sugars derived from biomass into fuels and bioproducts. However, there is a massive gap between the physical form of raw cellulosic biomass and the… more
Abstract:Size reduction, or comminution, is a fundamental processing step for lignocellulosic biomass feedstocks used as a raw material for conversion to biofuels. Grinding or milling of herbaceous materials such as corn stover, switchgrass, miscanthus and other biofuel feedstocks consumes a lot of energy,… more
Abstract:ABSTRACT: The goal of the Space Test Program is to enable the US Air Force to rapidly develop emerging space technologies by providing economical flight opportunities to increase a technology"s TRL. Over the past decade, the CubeSat form factor has emerged as an economical platform for testing… more
Abstract:Leveraging TUI's SWIFT software defined radio (SDR) architecture, we propose to develop a 100 Mbps downlink and intersatellite crosslink capability with ranging and timing synchronization capabilities to enable more sophisticated CubeSat and small satellite missions. This effort will focus on… more
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