Abstract:DESCRIPTION (provided by applicant): We propose the Sirius workstation, an innovative microscope system combining the capabilities of automated neuron reconstruction using guided image collection, cell electrophysiological recording, and cell filling in li
ve tissue. Sirius will be the first… more
Abstract:DESCRIPTION (provided by applicant): The soil nematode, Caenorhabditis elegans (C. elegans), is a promising model organism to assess the effects of potential developmental and neurological toxicants on multi-cellular organisms. However, to determine the po
ssibility of using C. elegans as a… more
Abstract:DESCRIPTION (provided by applicant): A fast, cost-effective multispectral confocal imaging capability for high-resolution mapping in vivo will be created during this project. This new approach will be based on fiber Bragg gratings, a technology not utiliz
ed previously in biomedical imaging, and… more
Abstract:This project will design a miniature wireless reagent-less sensor to detect chemical, biological, and explosive materials in solid, liquid, and vapor form. These sensors are needed to implement a wide area hazard detection network to protect the health and welfare of the public. QuantaSpec will… more
Abstract:This project will adapt QuantaSpec's FDA funded research to develop a highly specific and sensitive test to detect malaria parasitemia using Fourier Transform Infrared (FTIR) spectroscopy. Furthermore, this test will be rapid, automated, inexpensive, reagent-less and highly accurate. Malaria… more
Abstract:This project will develop a bench-top system for the rapid identification of bloodstream infections. Rapid accurate infectious diagnostic systems are needed to identify effective therapy, reduce mortality, morbidity, and treatment costs. QuantaSpec will adapt its FDA funded work to develop a rapid… more
Abstract:Currently, no low-cost capacitors provide an elevated temperature, high reliability solution to the DC Bus Inverter need in hybrid electric vehicles. In previous work, an annular film capacitor design, which showed potential for use in the DC Bus application, was developed. The unique shape of the… more
Abstract:Seldon Laboratories, LLC, will apply its patented carbon nanotube filtration technology for air and nanoscale particulate engine exhaust filtration to NASA's Lunar Exploration challenges. This project focuses on the problem of efficient removal of nanoscale (10-100nm) and larger lunar dust… more
Abstract:In Phase 1 research, we developed algorithms to produce reduced-order models from High Performance Computations (HPC). These algorithms are unique, powerful, and particularly well-suited to the acoustic and seismic signal propagation problem. In this Phase 2 proposal, we seek to extend these… more
Abstract:DESCRIPTION (provided by applicant): The long term goal of this project is improvement in the quality of acupuncture treatment. This will be accomplished by developing a tool (the Acusensor) capable of tracking acupuncture needle movement and force interac
tions. The Acusensor will be applied… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop ways to leverage the teaching power of educational robotics to promote the learning of central big ideas in algebra. With its strong appeal and rich intellectual content, educational robotics has an established culture and… more
Abstract:This Small Business Innovative Research (SBIR) Phase II project continues the development of a visual interface that allows students to construct and investigate mathematical models. This research is undertaken with the goal of creating a general-purpose environment in which students, teachers, and… more
Abstract:The objective of this Phase I STTR proposal is to demonstrate the effectiveness of a several highly porous silica-based solids in the presence of chemical challenges from chemical warfare agents (CWAs) and toxic industrial chemicals (TICs). In Phase II, the most effective solids will be combined… more
Abstract:The Department of EnergyÂ¿s (DOE) remediation efforts have relied on numerical models to integrate laboratory and field characterization data, predict the fate and transport behavior of contaminant plumes, design remediation protocols to mitigate contaminant migration, and analyze data from field… more
Abstract:DESCRIPTION (provided by applicant): Our research is focused on the potential of acid-prepared mesoporous silica (APMS) as a delivery agent for siRNA constructs to inhibit the ERK1/2 and ERK5 pathways in the treatment of human malignant mesothelioma (MM).
These pathways are critical to MM cell… more
Abstract:"Expanding demand for organic produce is driving a need for larger quantities of
commercially-available organic seed. Concomitantly, organic producers wish to have the
superior qualities realizable in first-generation (F1) hybrids for many crops. This SBIR
project seeks to develop a cost-effective,… more
Abstract:DESCRIPTION (provided by applicant): Abstract Cell culture bioassays are often laborious and imprecise even after substantial development efforts. These bioassays are used broadly in the biotechnology industry to measure protein or vaccine products in deve
lopment and for lot release. Imprecise… more
Abstract:DESCRIPTION (provided by applicant): Full participation in the human social milieu requires that one be able to understand that other people have their own goals, intentions, and beliefs (which may or may not be correct) - and that these epistemic states g
overn people's behavior. This form of… more
Abstract:DESCRIPTION (provided by applicant): Rigorous quantification methods of histological specimens have become a keystone in modern neuroscience such as investigations of neurogenesis, stem cell research, neurotransplantation, neurotoxicology, and the pathogen
esis of neurodegenerative and… more
Abstract:DESCRIPTION (provided by applicant): Supervised group exercise has been shown to be an effective component for improving balance and preventing falls among elders who have suffered falls or exhibit a fear of falling due to frailty. In a Phase I SBIR study,
we developed a model for conducting group… more
Abstract:Embedded wireless sensors for corrosion monitoring of critical aircraft components are needed for improved condition based maintenance and future structural health monitoring (SHM) systems. The objective of this Phase I SBIR proposal is to design, develop, and test a corrosion measurement and data… more
Abstract:In the proposed work, we will develop a highly efficient and miniaturized vibration energy harvesting device suitable for use on drive system components of helicopters. The goal is to provide power to run a wireless corrosion hub and sensors (to be developed simultaneously in a separate program). … more
Abstract:Omni Measurement Systems, Inc already has a proposed solution to the liquid waste portion. Omni developed an extended wear, semi-automatic bladder relief device for aircrew through Air Force/Small Business Innovative Research (SBIR) Phase I, Phase II, Phase II Enhancement and Phase III contracts. … more
Abstract:Standoff detectors are required to detect IEDs. These detectectors are needed to save the lives of American soldiers. QuantaSpec has developed patent pending methods for long-range, sensitive, and selective standoff detection of explosives. These methods have already demonstrated sensitive remote… more
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