Abstract:Passive immunization with broadly neutralizing antibodies is a promising approach for preventionand treatment of HIV-1 infection. We have generated an HIV-1 neutralizing human antibody which bindsto the principal neutralizing determinant (PND) of the envelope glycoprotein gp12O. The antibody… more
Abstract:Development is proposed for a breakthrough technique involving the use of electro-magnetic radiation to detect and measure thickness of non-conductive coatings on both metallic and non-metallic surfaces. The primary objective of the Phase I effort will be to prove that this approach can detect all… more
Abstract:A significant problem in precision manufacturing of large parts/assemblies is the requirement to make measurements over the surfacesof these parts for a variety of reasons including inspection/quality control; control of surfacing operations such as coatings, abrasive erosion, buffing, and… more
Abstract:The research objective is synthesis of a conjugate of mitomycin C to an antisense phosphorothio-ate nucleotide targeted to proliferating smooth muscle cells responsible for arterial occlusion. This wouldprovide a novel approach to the prevention of restenosis, for which there is currently no… more
Abstract:This study will develop a new anti-thrombotic drugs for the treatment of thromboembolicdisorders. In pilot studies, a coagulation inhibitor has been identified in an aqueous extract of Anodontiawoodiana. Early chromatographic and spectral data suggest that the active principle(s) may be a… more
Abstract:Effective therapy for human immunodeficiency virus (HIV) infection remains elusive, partly dueto the fact that infected long lived cells provide a reservoir for the virus. Currently availableanti-retroviral agents are reverse transcriptase inhibitors. In spite of their success, these compoundshave… more
Abstract:We propose to research in-line real time wafer level monitoring techniques for use in development of new semiconductor processes and for the monitoring of semiconductor process equipment and techniques as a process control function. All of these techniques will monitor actual reliability failure… more
Abstract:Doppler velocity flow detectors have been used for years but cannot be applied directly to the aorta or pulmonary artery in closed chest patients, and are not accurate because of that. While access to the great vessels is easy during open-heart surgery many patients would benefit by doctors having… more
Abstract:THE GOAL OF THIS PROJECT IS TO DEVELOP A RIBONUCLEASE PROTECTION/MISMATCH ASSAY, WHICH WILL ALLOW THE DETECTION OF ESSENTIALLY ALL SINGLE-BASE MUTATIONS. SUCH AN ASSAY WOULD PROVIDE AN INEXPENSIVE AND WIDELY APPLICABLE METHOD FOR SCREENING FOR GENETIC DISEASES, DETECTING MUTATIONS IN ONCOGENES AND… more
Abstract:THE GOAL IS TO INCREASE THE NUMBER OF INDIVIDUALS WITH DEVELOPMENTAL OR OTHER DISABILITIES WHO HAVE ACCESS TO COMPUTERS AND COMMERCIALLY OFF-THE-SHELF SOFTWARE. THREE DEFICIENCIES IN CURRENTLY AVAILABLE SYSTEMS ARE A) MOST SYSTEMS DEMAND THE USE OF HANDS; B) THE RELATIVE INABILITY OF HEALHT-CARE… more
Abstract:THE ADOPTION AND FOSTER CARE ANALYSIS AND REPORTING SYSTEM (AFCARS) IS NATIONAL REPORTING SYSTEM WHICH IS CURRENTLY UNDER DEVELOPMENT. A WIDE RANGE OF PROBLEMS WILL BE EXPERIENCED BY STATES IN COMPLYING WITH THE COMPLEX AFCARS REQUIREMENTS. TO ASSIST STATES IN MEETING THESE REQUIREMENTS, FLEXIBLE,… more
Abstract:Measuring temperature in specimens being heated by electromagnetic energy requires the use of special probes. The temperature probes must be specially designed to minimize electromagnetic field perturbations. The probes in widespread usage in research institutes are thermistor sensors with very high… more
Abstract:THE PURPOSE OF THE INVESTIGATION IS TO PERFECT A NOVEL OPTICAL DEVICE THAT MEASURES THE OXYHEMOGLOBIN SATURATION (%HBO2), TOTAL HEMOGLOBIN CONCENTRATION (THB), AND OXYGEN CONTENT OF A BLOOD SAMPLE IN A GLASS CAPILLARY TUBE OF THE TYPE COMMONLY USED FOR MICROHEMATOCRIT DETERMINATIONS. WE HAVE ALREADY… more
Abstract:This is part of a program to develop gene medicines for treatment of dermatoses such as psoriasis. We will utilize a novel DNA expression vector (HK1) capable of directing high-level tissue-specific expression from keratinocytes in the epidermis. The HK1 vector contains transcription and translation… more
Abstract:An opportunity exists to develop a comprehensive model of the kinematics of a short-arm centrifuge, models of human physiologic response during centrifugation, and evaluation of techniques for balancing the torques created during operation of a short-arm centrifuge. The proposed Phase I program will… more
Abstract:An opportunity exists to develop a comprehensive model of the Aviator's Breathing System (ABS) which mathematically describes the dynamics of respiratory gas exchange in breathing systems for high performance military aircraft. The proposed Phase I development program will include a detailed review… more
Abstract:The design and layout of the bare base requires the assimilation and analysis of data from several sources of guidance. Without full consideration of this guidance, bare base planning may become time-consuming and inconsistent. The development of personal computer based bare base planning model… more
Abstract:A JUNE 1991 ESTIMATE SHOWS THAT MAGNITUDE OF THE AMERICAN AIDS CRISIS TO BE 115,984 DEAD, 182,834 SUFFERING WITH AIDS, AND 1 MILLION HIV POSITIVE (CDC). INTRAVENOUS (IV) DRUG USERS HAVE BEEN IDENTIFIED AS MAJOR VECTORS FOR THE SPREAD OF AIDS IN THE GENERAL POPULATION BECAUSE OF SHARING AND RE-USE OF… more
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