Abstract:DESCRIPTION (provided by applicant): Molecular interactions form the basis of healthy metabolism as well as the manifestation of disease, and comprise the very foundation of drug treatment. Tools available to study molecular interactions in their nascent environment and physiological concentrations… more
Abstract:Alcohol abuse and its related health effects are estimated to have an economic cost in the US that approaches $200 Billion per year. However, current tests for alcohol use/abuse are not reliable except when administered within several hours of intoxication. Moreover, current clinical tests for… more
Abstract:In response to the proposal solicitation of''Wideband Scalable Multi-channel Digital Receiver/Exciter (DREX)', this proposal presents a phase-I research plan committing to provide a set of study and experiment results, and conceptual design of a scalable coherence method. A new… more
Abstract:The software system, Sensor Atom Configuration Software (SACS), will use of knowledge management techniques through ontologies capturing knowledge about sensor atoms and 3D targets, advance algorithm design, and concept of operations to allow for flexible sensor system design and predict sensor… more
Abstract:This Small Business Innovation Research Phase I project will develop the technology needed for high performance scintillating optical fiber-based neutron detectors. Current scintillator technology has the potential to produce neutron detectors that are extremely sensitive, rugged, flexible in… more
Abstract:Kinase inhibitors such as Gleevec and Tarceva have markedly improved cancer therapy. Essential to the use of such inhibitors are companion diagnostics enabling determination of the mutational status of th eir kinase targets in tumors. Anaplastic lymphoma kinase (ALK) fusion oncogenes have emerged… more
Abstract:This Small Business Innovation Research (SBIR) Phase I focuses on the development of a systematic methodology for the usability study of academic electronic health records (EHR) systems to guide the development of iCare, an academic EHR clinical simulation tool, with the aim to provide undergraduate… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop and test a non-thermal atmospheric plasma food processing technology to reduce microbial populations on fresh produce. The technology will reduce the risk of foodborne infections while decreasing microbial spoilage,… more
Abstract:Fiber lasers have emerged as a promising technology for future high energy laser (HEL) weapons systems, having demonstrated single mode, CW operation at 10kW power level and high electrical to optical conversion efficiency (>25%). However, commercial fiber lasers are not practical for beam… more
Abstract:Accurate Automation Corporation (AAC) proposes to provide a source that can meet the requirements of this present solicitation using a technical approach based on recent breakthrough technology that has made it possible to design a scalable fiber optic laser that can operate in all of the low loss… more
Abstract:Accurate Automation will design and build a Multiple Engagement Autonomous Neutralizer (MEAN) System that will allow an EOD team to quickly and safely engage multiple IEDs from a safe area. This design exceeds capabilities of any current system because it will allow the technician to preload the… more
Abstract:Accurate Automation Corporation proposes to develop a high power switch with a laser trigger to minimize pulse-to-pulse jitter. The switch will incorporate carbon nanotube electrodes for long life and high current capacity. The initial design of the switch will provide switching of up to 25 kV DC.… more
Abstract:There currently exists no end-to-end reactor/power conversion monitoring system that can provide both autonomous health monitoring, but also in-situ sensor calibration and response time testing without human interface. One of the key challenges facing space nuclear power systems is their extremely… more
Abstract:The health and integrity of aircraft sensors and instruments play a critical role in aviation safety. However, inaccurate or false readings from these same sensors/instruments can lead to improper decision-making resulting in serious if not fatal consequences. This proposal offers a research and… more
Abstract:A hands-on research and development effort is proposed for an advanced portable cable testing system with specific monitoring and diagnostic capabilities for submerged outboard electrical cables installed in U.S. Navy surface craft and submarines. The focus in Phase I will be on design of equipment… more
Abstract:In the U.S., almost all 104 operating commercial nuclear power plants have applied or plan to apply for license renewal, and over 50 percent have already received approval. This allows the utilities who own these plants to operate them for up to 60 years, and discussions have already begun for a… more
Abstract:The designs of many existing nuclear power reactors incorporate a digital rod position indication system to monitor the positions of the control and shutdown rods within the reactor. These digital rod position indication systems have been in service for over 30 years in nuclear power stations… more
Abstract:In this period of the nuclear energy renaissance and recognition of the role that nuclear energy can play in carbon free power production and energy security, the value of the existing fleet of nuclear power plants and the need for construction of additional units have become obvious in recent years… more
Abstract:Like any large-scale industrial environment, the safe and efficient operation of a nuclear reactor is a function of the health of the equipment and components that make up the plant. Although nuclear power plants have provided a reliable source of power for the U.S. over the last four decades,… more
Abstract:Over the last decade, on-line monitoring (OLM) technologies have become prevalent in most industrial processes including nuclear power plants for equipment and process condition monitoring, predictive maintenance, aging management, and life extension. However, research reactors have not benefited… more
Abstract:In the U.S., almost all 104 operating commercial nuclear power plants have applied for or plan to apply for, or have already received license renewal to allow operation for up to 60 years. As the plants age, safe operation becomes increasingly important and more frequent monitoring of the health of… more
Abstract:DESCRIPTION (provided by applicant): Islet transplantation (ITx), especially with the emerging potential of xenotransplantation, holds significant promise for the treatment of type 1 diabetes (T1D). There are, however, major challenges that remain prior toits larger scale, cost-effective application… more
Abstract:DESCRIPTION (provided by applicant): Summary Overall, 36% of adult Americans, and 66% of Latinos, lack the level of health literacy needed to understand prescription drug information, such as the dosing instructions on medication container labels. Low hea
lth literacy and poor understanding of… more
Abstract:Lightweight Divert and Attitude Control Systems (DACS) can improve the mass fraction and specific impulse capabilities of propulsion systems for future MDA platforms. Proposed is the development of a novel DACS valve and actuator to provide improved capabilities for a wide range of future systems. … more
Abstract:Piezoelectric actuators constructed with the "smart material" PZT offer many potential advantages for use in NASA cryo-valve missions relative to conventional electromagnetic-driven mechanical actuators. In addition to their very high resolution (a benefit to nanopositioning applications for many… more
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