Abstract:DESCRIPTION (provided by applicant): The overall goal of our work is to establish the potency and efficacy of a novel 2-adrenergic receptor agonist (compound 49b) in the prevention and/or reversal of non-proliferative diabetic retinopathy. Diabetic retinopathy is the leading cause of blindness… more
Abstract:Difficulties associated with thick lithium-diffused entrance windows on the outside of p-type coaxial and point-contact germanium gamma-ray detectors have always been a technical hindrance. The lithium dead layer limits the low-energy detection range and adds background in the energy spectrum,… more
Abstract:DOE Nuclear Physics user facilities require larger high-resolution gamma-ray detector systems to provide higher sensitivity measurements. Large diameter germanium crystals are being grown, evaluated, and iteratively improved in the laboratory. Large-diameter crystals will be made into large… more
Abstract:No satisfactory medical interventions for radiation enteritis are available yet. We have demonstrated that polyamine inhibition by a-difluoromethylornithine orDFMO, a selective and irreversible inhibitor of ornithine decarboxylase (ODC, the primary rate-limiting enzyme in the production of… more
Abstract:The United States Air Force (USAF) operates one of the world"s largest fleets with an average age approaching 26 years. As the USAF transport fleet continues to age, costs of inspections, structural repairs, and component replacements will continue increasing. Given this large number of… more
Abstract:Analysis methods are not available to predict the life of structures exposed to spectral loads containing large cycles of low amplitude loads. The challenge is developing a computational technique to predict damage accumulation in the ultra high cycle fatigue (UHCF) regime and then integrate that… more
Abstract:Advanced computational tools capable of predicting the effects of fatigue corrosion on new alloys are needed to design the aircraft fleet of the future. The corrosion process is complex involving a combination of factors including material chemistry, processing history, microstructure, and… more
Abstract:The proposed project will develop a structural analysis framework incorporating high performance composite design methodologies to predict the reliability of sandwich termination features. The sandwich core termination region offers many challenges to properly design and verify its structural… more
Abstract:DESCRIPTION (provided by applicant): Tympanic membrane perforations are commonly seen in otology practices and about 150,000 repair surgeries are performed each year in the United States. Current office-based procedures such as paper patch tympanoplasty are relatively ineffective or, like the… more
Abstract:DESCRIPTION (provided by applicant): Annually, 5 to 7 million Americans are treated for chronic wounds that arise from diabetes, lower extremity arterial disease, lower extremity venous disease and edema, and pressure ulcers, and traumatic injuries, including burns. There is a real need for new… more
Abstract:DESCRIPTION (provided by applicant): Germanium gamma-ray imaging detectors will improve the quality of in-vivo molecular-imaging applications. The objective of this program is the development of the Germanium Gamma Cameras (GGCs) as modular component detector heads suitable for convenient… more
Abstract:DESCRIPTION (provided by applicant): Stroke is the 3rd leading cause of death and the primary cause of severe, long term disability. Each year 795,000 Americans have a stroke and the annual costs to the economy are 57.9 billion. The vast majority of acute ischemic strokes are caused by a thrombus… more
Abstract:It is becoming increasingly apparent that we, as a nation, need to quickly develop smarter solutions to control the overall generation and distribution of electrical energy as power demand across the grid expands in response to the increasing population and the growing prospect of energy intensive… more
Abstract:DESCRIPTION (provided by applicant): Molecular interactions form the basis of healthy metabolism as well as the manifestation of disease, and comprise the very foundation of drug treatment. Tools available to study molecular interactions in their nascent environment and physiological concentrations… more
Abstract:Alcohol abuse and its related health effects are estimated to have an economic cost in the US that approaches $200 Billion per year. However, current tests for alcohol use/abuse are not reliable except when administered within several hours of intoxication. Moreover, current clinical tests for… more
Abstract:In response to the proposal solicitation of''Wideband Scalable Multi-channel Digital Receiver/Exciter (DREX)', this proposal presents a phase-I research plan committing to provide a set of study and experiment results, and conceptual design of a scalable coherence method. A new… more
Abstract:The software system, Sensor Atom Configuration Software (SACS), will use of knowledge management techniques through ontologies capturing knowledge about sensor atoms and 3D targets, advance algorithm design, and concept of operations to allow for flexible sensor system design and predict sensor… more
Abstract:This Small Business Innovation Research Phase I project will develop the technology needed for high performance scintillating optical fiber-based neutron detectors. Current scintillator technology has the potential to produce neutron detectors that are extremely sensitive, rugged, flexible in… more
Abstract:Kinase inhibitors such as Gleevec and Tarceva have markedly improved cancer therapy. Essential to the use of such inhibitors are companion diagnostics enabling determination of the mutational status of th eir kinase targets in tumors. Anaplastic lymphoma kinase (ALK) fusion oncogenes have emerged… more
Abstract:This Small Business Innovation Research (SBIR) Phase I focuses on the development of a systematic methodology for the usability study of academic electronic health records (EHR) systems to guide the development of iCare, an academic EHR clinical simulation tool, with the aim to provide undergraduate… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop and test a non-thermal atmospheric plasma food processing technology to reduce microbial populations on fresh produce. The technology will reduce the risk of foodborne infections while decreasing microbial spoilage,… more
Abstract:Fiber lasers have emerged as a promising technology for future high energy laser (HEL) weapons systems, having demonstrated single mode, CW operation at 10kW power level and high electrical to optical conversion efficiency (>25%). However, commercial fiber lasers are not practical for beam… more
Abstract:Accurate Automation Corporation (AAC) proposes to provide a source that can meet the requirements of this present solicitation using a technical approach based on recent breakthrough technology that has made it possible to design a scalable fiber optic laser that can operate in all of the low loss… more
Abstract:Accurate Automation will design and build a Multiple Engagement Autonomous Neutralizer (MEAN) System that will allow an EOD team to quickly and safely engage multiple IEDs from a safe area. This design exceeds capabilities of any current system because it will allow the technician to preload the… more
Abstract:Accurate Automation Corporation proposes to develop a high power switch with a laser trigger to minimize pulse-to-pulse jitter. The switch will incorporate carbon nanotube electrodes for long life and high current capacity. The initial design of the switch will provide switching of up to 25 kV DC.… more
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