Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR project is aimed at developing a novel type of drugs, termed SNX9-class compounds, with a unique combination of two anticancer activities. The first is a selective antiproliferative effect on tumor cells relative to normal cells. The second is… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project explores and develops novel wireless powered embedded sensors that have the potentials to revolutionize wireless sensing and communications for future non-intrusive structural health monitoring. The embedded nature of these sensors will… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to identify and develop drugs that induce mitochondrial biogenesis. A variety of diverse acute insults such as ischemia/reperfusion (I/R), drug, toxicant, and trauma lead to mitochondrial dysfunction and results in cell… more
Abstract:DESCRIPTION (provided by applicant): The kidney is a target of toxicity from drugs, and industrial and environmental chemicals because of its high blood flow, numerous transporters, and reliance on aerobic metabolism. Not surprisingly, mitochondria are acommon intracellular target of chemicals in… more
Abstract:DESCRIPTION (provided by applicant): This proposal is in response to PA-07-436 Bioengineering Approaches to Energy Balance and Obesity (STTR [R41/R42]) . In this project we will assess a wrist-worn bite counter for monitoring food intake. Specifically,we will evaluate the device across different… more
Abstract:DESCRIPTION (provided by applicant): NUBAD, LLC is a drug discovery company devoted to identifying therapeutic agents that target nucleic acids. This project is designed to synthesize and characterize a novel class of fluorescently-labeled aminoglycosidesthat exhibit a dramatic change in… more
Abstract:DESCRIPTION (provided by applicant): A major cause of morbidity and mortality in cardiovascular surgery is excessive bleeding post- operatively, which is commonly managed by pharmacologically modifying clot degradation (fibrinolysis), through inhibition of plasmin activity (PLact). However, the only… more
Abstract:DESCRIPTION (provided by applicant): Carbonix LLC proposes a Phase I research program on its novel process that abates indoor allergenic proteins that are implicated in allergies and asthma attacks. Common allergenic proteins are produced, for example, by
household dust mites and cats. It is… more
Abstract:DESCRIPTION (provided by applicant): The kidney is a target of toxicity from drugs, and industrial and environmental chemicals because of its high blood flow, numerous transporters, and reliance on aerobic metabolism. Not surprisingly, mitochondria are a c
ommon intracellular target of chemicals in… more
Abstract:This project addresses the problem of increasing biomass feed to electricity-generating power furnaces with the goal of reducing GHGs. Currently wood pellets are burned, but the ash content and lower energy density limit their use. Lignin pellets have approximately the same energy content as coal,… more
Abstract:This project allows pulp and paper mills to extract a purified lignin stream from their recovery process. By making up the fuel value of this extracted lignin the mill remains carbon neutral. A power company that can replace coal with lignin achieves a significant GHG reduction. The sequential… more
Abstract:The Insensitive Munitions (IM) compliant initiation system uses a unique approach to initiate the TATB. The initiation systems departure from standard approaches is the design uses all the stored energy as compared to standard approaches that use a small percentage of the stored energy with the… more
Abstract:DESCRIPTION (provided by applicant): Multiple sequence alignment (MSA) is a core element of bioinformatics, comparative genomics, phylogenetics, molecular, and structural biology. Several excellent software tools for MSA construction are heavily used by th
e biomedical community; however,… more
Abstract:DESCRIPTION (provided by applicant): Renal transplantation has been a clinical reality for nearly 40 years. Transplantation is the only effective solution for organ end-stage renal failure. Long term renal function following transplantation has been shown
to be better when kidneys are not subjected… more
Abstract:DESCRIPTION (provided by applicant): In an effort to reduce the use of animals for toxicity testing, companies have developed in vitro skin models or equivalents to replace the Draize skin irritation test. This development has been further pushed by a Euro
pean Union regulation that will prohibit… more
Abstract:DESCRIPTION (provided by applicant): Available methods for molecular structure determination, based primarily on x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods, have had limited success on the insoluble proteins that are critic
al to biological function. Various recent… more
Abstract:This SBIR Phase I project will demonstrate that a novel thermodynamic cycle could enable a 50% improvement in conversion efficiency from geothermal and concentrated solar sources when the two are synergistically combined.
The broader/commercial impact of the proposed project could be as much as a… more
Abstract:DESCRIPTION (provided by applicant): According to the American Diabetes Association, there are more than 16 million people in the United States with known diabetes. Diabetic patients commonly demonstrate impaired wound healing. Approximately 20 percent of
patients with diabetes will develop foot… more
Abstract:Advanced Core Technologies brings 3 advanced competencies together to identify, foster, and deploy technologies promising reliability enhancing materials and manufacturing innovations. Self-learning search methods, sophisticated information association techniques, and stochastic forecaasting… more
Abstract:The availability of ultra-high speed imaging equipment capable of frame rates up to 1 GHz has opened the potential for measurement of full-field three-dimensional deformation data during highly dynamic events by employing the digital image correlation method. However, due to the characteristics of… more
Abstract:A user-friendly software package for rapid fatigue evaluation of specific scalable flaw geometries, as well as stable tearing after crack length reaches a specified size, is being developed. The package will employ modified CRACK3D code and use VCCT with 10-noded tetrahedral elements to determine… more
Abstract:The objective of this proposal is to demonstrate the feasibility and performance of compact, efficient, radiation hardened laser technology for LADAR detection, ranging and range-gated imaging applications. Traditional laser designs exhibit modest wall plug efficiencies. They are limited in… more
Abstract:Kigre proposes to develop and integrate unique radiation hardened, athermal, 1.5um laser gain materials and pumping architectures into high performance optical laser amplifier devices for SATCOM applications. The approach employs long life radiation tolerant pump diodes configured for direct side… more
Abstract:This SBIR Phase II project will result in Nitek Inc. commercializing high power, large area, UVC-LED Lamps based on a novel vertically conducting geometry that is arbitrarily scalable. AlInGaN based deep UVC-LEDs (Ar
Abstract:DESCRIPTION (provided by applicant): Hernial repair is the most frequent operation in general surgery for which synthetic meshes are commonly used in repairing abdominal defects. Frequently used meshes consist of non-absorbable polymers such as polypropyle
ne, polyethylene terephthalate, or… more
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