Abstract:DESCRIPTION (provided by applicant): There is a well-recognized need to develop vaccines that stimulates humoral immunity as well as a potent T cell immunity in order to achieve protection from infection with pathogens. Although numerous investigations arefocused on developing vaccines that induce… more
Abstract:This project builds on patterns derived from natural antimicrobial peptide sequences to develop novel compounds with better systemic activity, lower cytotoxicity and broader spectrum activity against multidrug resistant (MDR) pathogens. In Phase I and the
Abstract:DESCRIPTION (provided by applicant): This is a proposal to develop newly discovered sulfamoylbenzamide derivatives as therapeutic agents for the treatment of chronic hepatitis B virus (HBV) infection. These molecules have been identified as inhibitors of HBV pregenomic (pg) RNA encapsidation, a… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a design concept and demonstrate the feasibility of a continuous process to produce low-cost silicon wafers for solar cells. The approach is to cool a molten bath of silicon from the top to be below its melting point,… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a pilot-scale production system and process to enable the large-scale fabrication of continuous arrays of elastomeric micro/nano-scale fibers with complex geometry. Inspired by hairs that occur naturally on gecko feet,… more
Abstract:DESCRIPTION (provided by applicant): When presented with a suitable antigenic Envelope (Env) structure, the human immune system can produce protective antibodies that HIV is unable to evade. Many of the most potently neutralizing HIV antibodies identifiedto date preferentially bind the trimeric… more
Abstract:DESCRIPTION (provided by applicant): We propose to use a novel technology, the Lipoparticle, to capture and concentrate structurally intact membrane proteins in a format amenable to phage panning for MAb isolation. The use of Lipoparticles to pan phage display libraries represents a valuable… more
Abstract:This Phase II SBIR proposal responds to a CBD need for improved Acoustically Enhanced Impaction (AEI) air purification in support of low pressure drop filtration. Prior to the SBIR Phase I effort, a first generation/benchmark (AEI) system developed by Applied Research Associates, Inc. (ARA)… more
Abstract:Detection and tracking of moving vehicles and dismounts across the land-sea boundary is very challenging because of the highly complicated dynamic heterogeneous littoral clutter environment. LSI proposes knowledge based adaptive signal processing techniques that will ultimately sense the dynamics of… more
Abstract:Sensor exploitation management is a key enabling technology to optimally use the capabilities of airborne radar systems with and without an operator-in-the-loop. LSI proposes to develop this capability to compliment a sensor resource manager capability that when integrated will result in… more
Abstract:Surface vessel detection and classification from airborne platforms relies heavily on radar at operationally useful stand off ranges. Upon detection the radar search waveform may be used to accrue additional information about the surface contact for classification but confidence is likely to be… more
Abstract:DESCRIPTION (provided by applicant): In the last decade there has been an explosive growth in the field of ubiquitin research, with approximately 530 human genes predicted to encode enzymes involved in the conjugation and deconjugation of ubiquitin. Of these 95 encode for deubiquitylases (DUBs). In… more
Abstract:DESCRIPTION (provided by applicant): Identification, quantification, and isolation of low abundance proteins from complex mixtures is, at best, a difficult task. This is especially the case for proteins carrying a post-translational modification (PTM) that affects their half-life or regulatory… more
Abstract:LithChem Energy (LCE) has developed a very high power (>12,000 W/kg) reserve battery for use in interceptor missiles such as the SM3-IIB where weight (power density) is very critical. This battery can be 100% checked and cycled before actual mission use to ensure 100% reliability and can be… more
Abstract:Nationwide about 2.4 billion gallons of lubricants are consumed annually for automotive crankcase (about 58%), industrial processes, machine lubrication, mining, and others. About 1 billion gallons/yr is currently collected as waste oil, equivalent to1-1.5% of annual US crude oil import volume. … more
Abstract:Advanced composite material systems are vital to the development of lightweight, multi-functional Army missile systems. In addition to reducing the weight of the structure, these material systems provide the ability to expand the function of the structure by tailoring stiffness and strength… more
Abstract:The current welded aluminum ramps on the Navy"s Landing Craft Air Cushion (LCAC) hovercraft are prone to damage related to extreme vehicle and seaway load requirements in combination with corrosion and erosion due to the harsh salt-laden marine environment in which they operate. Improving… more
Abstract:The use of multiple materials on aircraft can result in galvanic corrosion, accelerated by the aggressive Navy operational environment. Traditional approaches to minimizing the galvanic activity of structural designs rely heavily on sealants, coatings, and other barrier techniques, all of which may… more
Abstract:In this proposal, Materials Sciences Corporation (MSC) and its manufacturing partner Seemann Composites Inc. (SCI) have defined several synergistic material science innovations that have the potential to lower the cost, or increase the performance at the current cost, of surface combatant sonar… more
Abstract:Layflat hoseline is used in Army water and fuel systems to transport bulk fluid over varying distances. Ease of storage, layout, and retrieval are desired characteristics offered by layflat hoses currently in use. In order to meet the Armys need for an improved hoseline with a higher working… more
Abstract:The primary objective of the proposed Phase II SBIR program is to demonstrate material modeling and process simulation tools for predicting properties of thermoplastic matrix composites (TPMCs) for next generation aviation and missile structures. In order to sufficiently characterize the influence… more
Abstract:ABSTRACT: Future hypersonic vehicles, like X-43 and X-51 derivatives and Falcon HTV-3, will require advanced strategies for thermal protection systems (TPS) and methods of structural integration. The goal in designing TPS for these types of high performance applications is to establish… more
Abstract:Navy aircraft employ components that are contoured for aerodynamic performance and made of composite sandwich structures for high strength-to-weight ratio. Many of these components presently use honeycomb cores surrounded by thin high strength face sheets. While honeycomb is used extensively, it can… more
Abstract:One of the main drivers in the design of nozzles for advanced air-to-air missiles deals with erosion caused by combustion gases. Erosion can happen by melting/sublimation, oxidation and mechanical abrasion depending on the nature of the propellant. Current de Laval nozzles for air-to-air missile… more
Abstract:MaxPower has designed and built a prototype primary battery for use in the Rifleman Radio. At the end of the Phase II program, MaxPower delivered six prototype batteries to the U.S. Army for testing. Testing demonstrated that this battery system is able to provide over 15 hours operation at 6.6W… more
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