Abstract:Medical imaging and targeted therapy are the central components in the clinical management of cancer patients. Rockland Immunochemicals, Inc. is teaming up with Abzyme Therapeutics LLC to develop novel imaging agents that can be used in both cancer diagnosis and targeted therapy. In this phase I… more
Abstract:Although footwear science has made considerable progress in the last decade, a performance gap continues to exist between standard issue military footwear and expedition footwear available on the commercial market. While the provision of in-shoe foot orthoses (ISFOs) is commonplace in commercial… more
Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR proposal describes a strategy and work plan for accelerating to market a new device that will provide an evidence-based, patient-specific solution to a significant public health problem: foot pain. The TrueContour(R) therapeutic insole system… more
Abstract:ABSTRACT: While developing any complex system, there are invariably tradeoffs among requirements; system performance, system architecture, cost, schedule, risk, standard compliance, and other factors that decision-makers need to address. A team of experienced system engineers can be leveraged to… more
Abstract:As complex systems develop, there are inevitably changes to requirements and the system models as the team members formulate a more clear understanding of the customer needs and possible solutions. Often these changes are not coordinated since it is difficult to predict how one change may affect… more
Abstract:The CommLift Vertical Take-Off and Landing (VTOL) Unmanned Aerial Vehicle (UAV) is an alternate and novel approach to providing long range, over-the-horizon, communications for surface vessels; it uses a tethered electric UAV to carry a radio payload to suitable altitude, rather than an aerostat.… more
Abstract:DRS Scientific proposes a new type of Acousto-Optic Tuned Filter (AOTF) polarimetric hyperspectral imager that is compact, rugged, and inexpensive, has no moving parts, is free of optical aberrations, and is fast and sensitive. It will cover 8-12 mm with 8 cm-1 spectral resolution or finer, and… more
Abstract:High performance motors, like those in hybrid electric vehicles, use high performance Nd-Fe-B magnets that contain up to 12 wt% of dysprosium (Dy) in order to increase the coercivity, and avoid demagnetization at elevated temperatures. However, the global rare earth elements (Nd, Dy, etc) supply… more
Abstract:Rare earth element (REE) based Nd-Fe-B and Sm-Co permanent magnets have been widely used because of their excellent magnetic properties. The applications of Nd-Fe-B and Sm-Co rare earth permanent magnets include hybrid electric vehicles (HEVs), power generator for wind turbines, high performance… more
Abstract:The objective is to produce high efficiency DC/DC power modules in a small low profile package that can tolerate extreme environment conditions. The primary effort of the Phase II program is to address the need for very high performance power electronics that meet a combination of high radiation… more
Abstract:The program will leverage recent advances in striction materials and coupled striction devices as to enable highly isolated (analog) voltage and current flow sensors very suitable for harsh space environment power monitoring. Exhibiting negligible electromagnetic disturbance coupling and… more
Abstract:DESCRIPTION (provided by applicant): Infection is a common and frequently very serious complication associated with medical implants. Man-made materials, including those used to fabricate ventricular assist devices (VADs), compromise the body's ability tofight infection in tw ways. First, by… more
Abstract:Since 1990, Prime Synthesis, Inc. (PSI) has been a leading manufacturer of controlled pore glass (CPG). It has developed significant expertise in the optimization of physical characteristics and chemical modifications of CPG for a variety of applications. CPG has a unique combination of attributes… more
Abstract:ABSTRACT: During Phase I, FBS, Inc. developed and demonstrated a light-weight, low-power, non-thermal, ultrasound-based ice protection system for RPA wing leading edges and other metallic and composite components requiring ice protection. Low-profile, light-weight, low-power ultrasonic actuators… more
Abstract:This Small Business Innovation Research Phase I project is directed towards the development of a non-ionic thickening agent for personal care products, which does not contain poly(ethylene glycol) (PEG). Reports have stated that commercially available PEG contains small levels of undesirable side… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this application is to develop and validate a potential biomarker based assay to determine if it can be used as a noninvasive test to detect the stage of hepatic fibrosis and to predict fibrosis progression in HIV/HCV co-infected patients.… more
Abstract:DESCRIPTION (provided by applicant): This is a phase I proposal to determine the feasibility of developing newly discovered fluorinated sulfamoylbenzamide (FSBA) derivatives as therapeutic agents for the treatment of chronic hepatitis B virus (HBV) infection. These molecules have been identified as… more
Abstract:DESCRIPTION (provided by applicant): This is a proposal to implement a novel high throughput assay system to detect inhibitors of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) formation and/or maintenance. HBV cccDNA is essential to the virus life cycle and its elimination during… more
Abstract:DESCRIPTION (provided by applicant): DC-SIGN (dendritic cell specific ICAM-3-grabbing non-integrin), a membrane protein of C-type lectin family, is found in high levels on monocyte-derived DCs, some macrophages, and activated B cells. In vivo, DC-SIGN- positive cells were demonstrated in lymph nodes… more
Abstract:DESCRIPTION (provided by applicant): Acinetobacter are strictly aerobic, non-fermentative Gram-negative bacilli that are of major concern in human health, in particular the species Acinetobacter baumannii. They are responsible for clinically important infections that cause a wide variety of maladies… more
Abstract:DESCRIPTION (provided by applicant): We have identified a novel Type IIb prodrug of riluzole, FC-311, which has the potential to revolutionize therapy for the treatment of the devastating condition of metastatic melanoma acting via a novel glutamatergic mechanism of action, and also be useful to… more
Abstract:Valuable time is spent by astronauts performing simple, mundane, or ergonomically taxing tasks. Therefore, one center of focus for NASA is to have robots increasingly perform these tasks to give the crew more time flexibility. Robots are also employed with tasks that are too dangerous for humans or… more
Abstract:Hook and loop closures in Army uniforms have been identified as the critical sources of leaks in protective clothing/equipment, which limits the overall protective capability of the ensemble. New closure systems capable of providing both the shear and peel strengths demonstrated by hook and loop… more
Abstract:KCF proposes to build a general wireless hearing protection device validation system with miniature, wireless in real ear microphones. The microphones will be battery-free to enable the reduction in size necessary to fit in the canal for testing with any hearing protection device. KCF has… more
Abstract:KCF in partnership with Penn State will evaluate and demonstrate a new generation of intrinsically safe robotic actuators built up from micro-actuator module units. The technical approach is based on state-of-the art prosthetic development where the human-mechanism interface is the primary focus. … more
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