Abstract:DESCRIPTION (provided by applicant): Volitional, coordinated movement depends on proprioception to the extent that a loss of proprioception can lead to a lifetime of dyscoordinated movement. Proprioception can be adversely affected by spinal cord injury(SCI), stroke, and traumatic brain injury… more
Abstract:DESCRIPTION (provided by applicant): Tobacco is the leading cause of preventable disease and death in the U.S. Although effective tobacco cessation medications exist, the impact of these medications is diminished by lack of adherence by the patient. Basedon our team's expertise in the use of… more
Abstract:DESCRIPTION (provided by applicant): There is a great need for anti-malarial drugs that are inexpensive and effective against drug-resistant strains. Malaria is one of the most important diseases worldwide, with over 225 million cases each year, and about800 thousand deaths. Most of these deaths… more
Abstract:DESCRIPTION (provided by applicant): The goal of this SBIR project is to design a cost-effective, lightweight, integrated, whole-head dense-array electroencephalography and near-infrared spectroscopy (dEEG/NIRS) brain imaging and data analysis system for non-invasive recording of brain activity in… more
Abstract:The purpose of the proposed work is to demonstrate the feasibility of a novel instrument for multi-channel nuclear Magnetic Resonance Imaging (MRI) at ultra-low field (ULF). The instrument will overcome issues involved with conventional MRI systems use in combat casualty care. It will also provide… more
Abstract:DESCRIPTION (provided by applicant): Clinical neonatal monitoring is also vital for diagnosis and prognosis of acute pathologies. One such pathology, neonatal intraventricular hemorrhage (IVH), is a common consequence of premature birth, with approximately30 percent of infants weighing less than… more
Abstract:We propose a hollow reservoir cathode to improve performance in ion and Hall thrusters. We will adapt our existing reservoir cathode technology to this purpose. Reservoir cathodes are the only emission sources that are capable of supplying the necessary current density (>5.0 A/cm2) and life… more
Abstract:DESCRIPTION (provided by applicant): This SBIR Phase II grant will support the commercial development of an injectable biological product candidate, a unique proprietary recombinant humanized anti-factor XI monoclonal antibody (AXIMAB), towards an investigational new drug (IND) application. The lead… more
Abstract:DESCRIPTION (provided by applicant): Thrombotic cardiovascular diseases including venous thromboembolism (VTE), deep vein thrombosis (DVT), myocardial infarction, and ischemic stroke, remain leading causes of death and disability in the U.S. Although effective antithrombotic agents are available,… more
Abstract:DESCRIPTION (provided by applicant): One of the underlying causes of acute ischemic stroke (AIS) is the thrombotic-thromboembolic occlusion of cerebral blood vessels. Early use of tissue-type plasminogen activator (tPA, Activase(R)), currently the only FDA-approved treatment for AIS, can promote… more
Abstract:The so-called"software crisis"is continuing unabated. It is all too common for a software project to create software that is hard to maintain, inefficient, bug-ridden, late, and over-budget. Software flaws resulting from this current state of affairs are no longer an inconvenience but… more
Abstract:DoD operations and infrastructure increasingly depends on software, which makes it an attractive target for our adversaries. Not surprisingly, deception plays a central role in most cyberattacks. To better protect these critical systems, we propose to design and build an"active… more
Abstract:We propose to build a separation kernel with stronger evidence of correctness than any current product on the market. We will do this by building on work done by Australia's National Information Communications Technology Research Center (NICTA), which includes a complete code-level formal proof… more
Abstract:Many hardware trojans depend on (a) the ability of an attacker to have an accurate model of the target system and of key software used on that system and (b) identification of one or more deterministic trigger conditions with low observability (i.e., conditions that evade detection by traditional… more
Abstract:GreenWood Resources proposes to develop hybrid poplar growing stock of improved water-use efficiency using a strategy of species selection, inter-specific hybridization, and varietal selection. The proposed work will lead to an increase in the cost-efficiency of current sawlog production and future… more
Abstract:With the Titan Saturn System Mission, NASA is proposing to send a Montgolfiere balloon to probe the atmosphere of Titan. To better plan this mission and create a robust optimized balloon design, NASA requires the ability to more accurately evaluate the convective heat transfer characteristics of… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop spin-coatable liquid precursors for extremely high etch resistance pattern transfer layers (hardmasks) to enable novel devices in advanced integrated circuit manufacturing. The approach is to employ the fully inorganic… more
Abstract:This Small Business Innovation Research Phase I project develops a method of lifting-off an epitaxially grown high-efficiency (>30%) triple-junction III-V solar cell from a Ge or GaAs wafer onto a polyimide substrate. A high-coefficient of thermal expansion (CTE) polyimide wafer is used to induce… more
Abstract:PROJECT SUMMARY Autism is fast becoming an epidemic among American children. Between 2007 and 2009, the CDC reported an average increase in cases of 57 percent, from 1 in 150 children to 1 in 110 children. While improved awareness and identification accounted for some of this increase, the CDC… more
Abstract:DESCRIPTION (provided by applicant): Latino youth currently comprise more than one-fifth of the US youth population (Mather and Foxen, 2010), yet this sizeable group of the nation s future adults lags alarmingly behind non-Latino youth in academic achievement. The proposed program, Padres… more
Abstract:The identification and tracking of objects of interest to the Ballistic Missile Defense System (BMDS) depends upon detection, measurement/classification, and visualization of the radiation emitted by these objects. Since BMDS operation is strongly tied to imagery, the input of synthetic imagery… more
Abstract:DESCRIPTION (provided by applicant): While foster-adoptive parents receive some rudimentary training just prior to or in the early months following adoption finalization, many stil harbor unrealistic expectations about adoption and are unaware of the severe behavioral problems they may encounter, no… more
Abstract:DESCRIPTION (provided by applicant): In this revised Phase II, the project will develop and evaluate a set of five online training workshops designed to help foster-adoptive and kinship parents safely and empathically understand and reduce externalized behavior problems of children ages 3-10 in… more
Abstract:Advanced battery recycling has potential to significantly reduce end-of-life cost for large format batteries. Available technology melts or dissolves batteries to recover cobalt or nickel, destroying advanced materials with potential for manufacturing use. With little elemental value in… more
Abstract:DESCRIPTION (provided by applicant): Excessive alcohol consumption is a public health concern that causes approximately 85,000 deaths each year and costs the U.S. economy 185 billion annually. Because the large majority (79%) of adults with alcohol disorders are employed and Employee Assistance… more
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