Abstract:Transmissible spongiform encephalopathies (TSE's), or prion diseases, are caused by a unique transmissible agent hypothesized to be a misfolded form (PrPD) of a normal host protein (PrPC). We will use chronic wasting disease (CWD) as a model prion agent because of growing concern about this agent,… more
Abstract:"The National Research Council has concluded that ammonia is a major concern for
air quality at global, national and regional scales. In the US, livestock operations are
believed to contribute over 80% of the total emissions of ammonia. Specific interest in
ammonia emissions from livestock… more
Abstract:"This project will test the feasibility of a breath alkane as an indicator of respiratory health in
bovine. Significant losses due to bovine respiratory disease (BRD) occur in the U.S. beef
industry with estimated annual losses at $1 billion due to higher medical costs, decreased weight
gain, lower… more
Abstract:Passage in 1996 of the Food Quality Protection Act (FQPA) and Amendments to the Safe Drinking Water Act (SDW) reflected these concerns and required EPA to develop a screening program, using appropriate validation test systems and other scientifically relevant information, to determine whether… more
Abstract:The Army is using robots in ever increasing number to execute it mission across its spectrum of operations. Although these robots provide significant operational benefits, the Army currently lacks an adequate, automated Command and Control (C2) systems to communicate relevant information from them… more
Abstract:DESCRIPTION (provided by applicant): At InterGenetics Incorporated we have developed a prototype multigenic, logistic regression model, called OncoVue(r), to predict sporadic breast cancer risk. This model incorporates polymorphisms in several genes invol
ved in diverse processes implicated in… more
Abstract:The objective of this proposal is to further develop IV-VI PbSnSe detectors epitaxially grown on Si substrates. The motivation of fabricating IV-VI detector arrays on Si is based on the following advantages of IV-VI Pb-salt semiconductors. (1) The large dielectric constant helps screen and localize… more
Abstract:In this Phase II project Nomadics will novate our research to a spin-out company Nico Technologies. Nomadics will remain a subcontractor during this transition. The team proposes a new treatment for injuries from mustard gas based on biodegradable inverted colloidal crystal scaffolds impregnated… more
Abstract:Many of the engineering tasks necessary for adequate Aircraft Battle Damage Repair Assessment are currently being performed manually. These manual engineering calculations can be arduous, time consuming, and error prone. Periodic turnover of ABDR personnel exacerbates this challenge and highlights… more
Abstract:DESCRIPTION (provided by applicant): Chronic idiopathic intestinal pseudo-obstruction (CIP) is a life-threatening disease without a cure. Severe postoperative ileus is common in patients after abdominal surgery and requires extensive hospitalization. Both
diseases are characterized with delayed… more
Abstract:HgCdTe, with its high quantum efficiency, remains the material of choice for most high-performance infrared detector applications. By varying its alloy composition, HgCdTe can be used for short wavelength to very long wavelength infrared (VLWIR); however, its use in VLWIR (12-16 microns)… more
Abstract:This Phase II Small Business Innovation Research project will deliver an innovative hydrogen passivation technique for improving manufacturability and performance of HgCdTe infrared detectors. Photon-Assisted Hydrogenation (PAH) causes the substrate to be hydrogenated by simultaneous exposure to… more
Abstract:perform Vertical Seismic Profiling (VSP) and passive seismic monitoring. However, this technology is very expensive to apply. Drilling a new well or taking a valuable well out of service is costly, as is VSP data acquisition and processing. Consequently, the technology is seldom used, and, hence,… more
Abstract:The overall objective of this proposal is to develop an innovative, generic methodology of fixturing with regard to the location and the clamping of workparts during manufacture, applied specially for small number of parts for each production lot as is typical in aircraft repair and maintenance
Abstract:The accurate numerical prediction of hazardous airborne plumes requires two important capabilities. First, meteorological conditions at fine spatial scale both at the time of plume release as well as a few hours into the future, and second, quantification of this information in a statistically… more
Abstract:Brushfire Technologies proposes to adapt our secure local area network gateway to the unique requirements of the DMO network to detect, analyze and mitigate security threats in real time with no adverse affects on network performance. Security analysis based on real time packet inspection coupled… more
Abstract:DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of blindness in the world. Diabetic macular edema (DME) and retinal neovascularization (NV) are the two major pathological alternations leading to the vision loss in diabetic… more
Abstract:DESCRIPTION (provided by applicant): Vascular leakage or increased vascular permeability in the retina is a common abnormality of diabetic retinopathy and can result in diabetic macular edema (DME), a major cause of vision loss in diabetic patients. Currently, there is no effective drug therapy to… more
Abstract:Transmissible spongiform encephalopathies (TSEs), or prion diseases, are caused by a unique transmissible agent hypothesized to be a misfolded form (PrPD) of a normal host protein (PrPC). We will use chronic wasting disease (CWD) as a model prion agent because there is an urgent need for increased… more
Abstract:This Small Business Technology Transfer Phase I project proposes the joint development of a compact/portable laser spectroscopic trace gas sensor based on quartz-enhanced photo-acoustic spectroscopy (QEPAS) recently demonstrated in the lab. QEPAS uses a low cost quartz tuning fork as the sensing… more
Abstract:This Small Business Technology Transfer (STTR) Phase I research project proposes to develop new methods for blue/UV laser fabrication. These new devices will have the competitive advantages of higher emission intensities, higher reliability, and ability to extend emission into the deep UV spectral… more
Abstract:Bovine Respiratory Disease is the most costly disease among cattle arriving at feedlots and results in decreased weight gain, lower quality meat and death. BRD is highly transmittable and a rapid and sensitive diagnostic method for BRD is not currently available. This project will validate a… more
Abstract:An important problem facing rural America is the lack of job opportunities. This is particularly true in much of the arid southwestern U.S. These rural communities have little that they can export into commodity priced markets. Hence, this region has among the highest incidence (% of county… more
Abstract:DESCRIPTION (provided by applicant): Functional gastrointestinal motility diseases are common and make up about 40% of all gastroenterology patients. Typical esophageal motor disorders include dysphasia, gastroesophageal reflux disease (GERD), non-cardiac chest pain, etc., however the effective… more
Abstract:The objective of this proposal is to further explore PbSnSe detector array on Si substrate. Two approaches are proposed. One is a zero-risk incremental advance that employs a new growth condition to reduce the dislocation density. Another approach is a novel fabrication technique with high-risk but… more
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