Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research Phase I research project seeks to develop a new technique for enhancing fluorescence-based detection of explosives in order to help counter the threat posed by… more
Abstract:DESCRIPTION (provided by applicant): Selexys Pharmaceuticals is developing a humanized monoclonal antibody drug directed against P-selectin for the treatment of vasoocclusive crisis in patients with sickle cell disease. P-selectin mediates the first step i
n the recruitment of white blood cells to… more
Abstract:DESCRIPTION (provided by applicant): Gastroparesis is a common disease defined as delayed emptying of the stomach. It is present in at least 20% of about 150 million patients with diabetes worldwide and in more than 20% of patients with functional dyspeps
ia that affects about 10%-25% of the… more
Abstract:This Navy SBIR Phase II program looks at the updating (both structural and electronics) of the current Controlled Towed Vehicle (CTV) and the fabrication of a new mount/enclosure that will allow for the mounting of the CTV system on a standard military style wing plyon. The vehicle is primarily for… more
Abstract:Yields and operability of high performance infrared focal plane arrays (IRFPAs), particularly those fabricated in HgCdTe, are severely impacted by material defects introduced during growth and/or processing. Amethyst Wafer Mapping (AWM) is a materials characterization technology which when fully… more
Abstract:Type II strained layer superlattice (SLS) p-n diode arrays fabricated on domestic-source GaSb substrates are a promising route to meet the critical need within DoD for large area, large format array infrared detectors. However, current SLS material quality is limiting detector performance. A… more
Abstract:While the initial application will be for cattle, the systems developed in this project will be applicable to feeders used for other domestic species including sheep, goats, and domestic hogs. In addition, the systems developed could be used to control gates or other access for animals or objects… more
Abstract:The Anautics CourseBook Project will address three national critical issues in mathematics education the need to support standards based instruction, the need to raise student achievement scores through effective teaching, the need for instruction management through electronic curriculum guidance,… more
Abstract:The Global War on Terrorism is increasing pressure for DOD depots to expedite the return of serviceable weapon systems to the warfighter while maintaining or decreasing maintenance costs. Each military service has responded to this challenge by undertaking enterprise-wide logistics modernization… more
Abstract:Many Department of Defense (DoD) weapon systems are operating beyond their original design specifications, resulting in failures requiring unplanned parts, materials and sustainment procedures. Such U.S. Air Force weapon systems are collectively denoted as aging aircraft. A large number of aging… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will examine the feasibility of a novel synthesis process for the creation of a composite hydrophobic nano-photocatalyst. The innovation is expected to allow enhanced volatile organic chemicals (VOC) and organic pollutant adsorptions in… more
Abstract:DESCRIPTION (provided by applicant): Linomide is a known anti-inflammatory drug. Recently we have synthesized a new analog of Linomide, linomide-5. The objective of this proposal is to develop linomide-5 as a therapeutic for treating diabetic retinopathy (
DR) and age-related macular degeneration… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to develop a service for the high-throughput drug screening of compounds to treat Age-Related Macular Degeneration (AMD). In our preliminary studies, we have identified a genetically-mo
dified mouse (Vldlr-/-) that presents with… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to examine the efficacy of CLT-005, a novel small molecule inhibitor of Stat3, for treating inflammatory and vascular leakage of the retina of diabetic retinopathy. Retinal blood vesse
l formation is known to be mediated by the… more
Abstract:Technological advances in energy harvesting (EH) offer significant benefits to powering micro aerial vehicles (MAVs) by extending mission length and range. Currently, batteries limit the range and mission time of MAVs since the batteries contain a finite supply of energy. The proposed research is… more
Abstract:DESCRIPTION (provided by applicant): Most cancer deaths occur from metastatic tumors rather than from the primary tumor alone. Although many of the new drugs in the past decade are directed against tumors , changes in overall cancer survival have only been
modest. Most cures of cancer are still… more
Abstract:DESCRIPTION (provided by applicant): Accurately estimating individualized probability of developing breast cancer over time is clinically useful for early detection and prevention. InterGenetics Incorporated has developed OncoVue(R), a model incorporating
multiple, commonly occurring genetic… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop a large-scale genotyping tool for metabolic muscle disease that can be applied to certain high risk groups in order to prevent life-threatening symptoms that are fast becoming a
public health problem. The triggering of… more
Abstract:Todays world and political climate lends itself to potential attacks by hostile forces and terrorists where both exterior and interior surfaces of vehicles, buildings, or equipment could become contaminated with biological warfare (BW) or chemical warfare (CW) agents. RTA Systems, Inc., proposes a… more
Abstract:The capture and use of carbon dioxide (CO2) from industrial plants for use in CO2 flooding of marginal oil reservoirs provides a dual use opportunity prior to final CO2 sequestration in the depleted reservoir. Miscible CO2 flooding processes greatly increase the recovery of crude oil from a… more
Abstract:DESCRIPTION (provided by applicant): The development of safe and effective female oral contraceptives (OCs) in the early 1960s provided a superior means of contraception and forever changed the dynamics of family planning. In fact, 82% of all women in the
U.S. have used OCs, which are one of the… more
Abstract:The Green Team, Inc. (tGT) will conduct Phase I research to determine characteristics of green product-service systems (GPSS) in the building products industry that effectively improve human health and the environment (e.g., improve sustainability). Knowledge of effective GPSS characteristics will… more
Abstract:DESCRIPTION (provided by applicant): Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. Over one million people get cancer each year. Approximately one out of every two American men and one out of every three A
merican women will have some type of cancer… more
Abstract:ZAI proposes to investigate advancing the capabilities of our Smart Towed Vehicle to be mounted and operated onto a more diverse range of aircraft and applications. Currently the STV has been fully tested and operated on a Twin Otter. During Phase I ZAI will look at mounted options for other… more
Abstract:High-performance infrared detectors are mission-critical components of each layer of the Ballistic Missile Defense System. MDA is investing heavily in technologies that enhance producibility/operability of LWIR/VLWIR infrared focal plane arrays (FPAs), and reduce BMDS life cycle costs. HgCdTe is… more
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