Abstract:This Small Business Innovation Research (SBIR) Phase II project will design, build, test, and validate a fully operational prototype disk drive incorporating a commutational ramp load actuator (CRLA). The CRLA is a unique and transformative actuator for disk drives that provides significant… more
Abstract:DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is a sight-threatening disease which represents the leading cause of blindness and visual impairment in elderly individuals in developed countries. Recently, laser and photodynamic therapies with limited clinical benefit… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation project aims to develop an innovative eye drop formulation for the treatment of glaucoma and ocular hypertension. Charlesson has acquired from Danube Pharmaceuticals MSH-1001, a new smallmolecule compound (previously known as… more
Abstract:DESCRIPTION (provided by applicant): The objective of this proposal is to finalize development of CLT-005, a novel small molecule inhibitor of Stat3, through the performance of studies required for the submission of an investigative new drug application with the US Food and Drug Administration… more
Abstract:DESCRIPTION (provided by applicant): Most patients with solid tumors die of tumor recurrence at the same site or metastasis of the tumor to distal sites. An intermediate step in both recurrence and metastasis is a stage called tumor dormancy, where the cancer cells are suppressed by a normal… more
Abstract:DESCRIPTION (provided by applicant): The primary objective of this proposal is to develop and commercialize a safe and more effective therapy for the treatment of Crohn's Disease, an inflammatory bowel disease. Crohn's Disease is a chronic inflammatory disorder of the gastrointestinal… more
Abstract:Active defects negatively impact the performance of IRFPAs by increasing noise at various levels up to, and including, catastrophic degradation. Evidence indicates that"killer defects"are related to the interaction of open core screw dislocations with impurities that remain after… more
Abstract:For HgCdTe infrared focal plane arrays fabricated on Si substrates, a model has recently been proposed to account for the disparity between the density of failed pixels and the density of dislocations that are present in the HgCdTe junction region. The model distinguishes between active and inactive… more
Abstract:Silicon wafers oriented on (112) are the preferred substrates for deposition of mercury cadmium telluride layers by molecular beam epitaxy. Surface defects introduced during polishing of the wafers degrade the quality of the epitaxy and the performance of infrared detectors fabricated within these… more
Abstract:The proposed research and development activities will determine the scientific, technical, and commercial feasibility of the use of solvent-free liquid
polymer-grafted surface wipes as novel materials that more efficiently removes low volatility chemical agent contamination from porous and… more
Abstract:DESCRIPTION (provided by applicant): Progressive disseminated histoplasmosis is a common and life-threatening fungal infection among patients with HIV/AIDS in the United States and Latin America. Incidence rates in HIV/AIDS can be gt20%, with mortality rates gt30% in resource-limited countries… more
Abstract:This project optimizes haptic system design parameters and more thoroughly evaluates the impact of a vibratory haptic system for prosthetics. Objectives include: (1) building a hardware and software test bed for non-invasive voluntary control of a prosthetic hand with vibratory haptic feedback, (2)… more
Abstract:The objective of lab-on-chip (LOC) or -TAS is to integrate and perform multiple analytical processes (e.g. sample pretreatment, solution distribution/mixing, separation, detection, etc.) on a microchip platform. So far, most LOC research has been focused on electrophoretic separations. Little has… more
Abstract:Due to their vast diversity and as-yet uncultivated status, detecting, characterizing and quantifying microorganisms in natural settings are of grand challenge, and understanding the mechanistic linkages between microbial diversity and ecosystem functioning and their feedback responses to human… more
Abstract:The interactions among different microbial populations in a community play critical roles in determining ecosystem functioning but very little is known about the network interactions in a microbial community due to the lack of appropriate experimental data and computational analytic tools.… more
Abstract:DESCRIPTION (provided by applicant): This is an application to test the efficacy of a new approach to cognitive training that is focused on higher level processes such as reasoning and inference. The proposal concerns content of interest to mature adults
. The product that will be developed out of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project develops a unique and transformative ramp load hard disk drive actuator that provides significant improvements over existing ramp load technology by increasing performance and reducing costs. A ramp is used to park the read/write heads… more
Abstract:This project optimizes haptic system design parameters and more thoroughly evaluates the impact of a vibratory haptic system for prosthetics. Objectives include: (1) building a hardware and software test bed for non-invasive voluntary control of a prosthetic hand with vibratory haptic feedback,… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a tumor-specific delivery technology based on the use of superparamagnetic nanoparticles as vehicles for the delivery of paclitaxel. The magnetic vectoring drug delivery platform uses external shaped magnetic field… more
Abstract:The ability of humans to make complex decisions is one of the most interesting aspects of human intelligence, especially when judgemental, ambiguous, absense, or erratic knowledge is concerned. This project focuses on the development of a methodology to classify multi-attribute alternatives into… more
Abstract:The Engineering Decision Support Framework (EDSF) will provide an engineer a SEAM based process lifecycle to implement detailed analysis of problem reports, assistance requests, requirements and other issues issues encountered. The engineer will be guided through the creation of criteria,… more
Abstract:The development of micro air vehicles (MAVs) will provide a military capability that has never before been fully realized. Technology developments in areas such as vehicle morphing and energy harvesting will enable greater mission capabilities in terms of intelligence, surveillance and… more
Abstract:As a result of a successful SBIR Phase I effort, Design Intelligence Incorporated, LLC (DII) analyzed and demonstrated the feasibility of innovative perching micro air vehicle (MAV) design concepts using multi-modal energy harvesting techniques. The proposed SBIR Phase II effort will develop an… more
Abstract:DESCRIPTION (provided by applicant): The primary objective of this proposal is to develop and commercialize a safe and more effective therapy for the treatment of Crohn's Disease, an inflammatory bowel disease. Crohn's Disease is a chronic inflammatory dis
order of the gastrointestinal tract that… more
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