Abstract:ABSTRACT: C9 Proposes to Develop a high Temperature Heating Element to Augment the Wind Tunnel at AEDC. The element will be fabricated by molding a creamic composite molding compound using methods developed for other defense and commercial applications. The element will be capable of surface… more
Abstract:Develop an inexpensive, easy to use, aerosolized delivery system of a combination of anti-tubercular drugs that could be used for the treatment of multi-drug resistant tuberculosis (MDR TB ). PUBLIC HEALTH RELEVANCE
Abstract:NASA's future X-ray astronomy missions will require X-ray optics that have large effective areas, are lightweight, and cost effective. Recent X-ray telescopes, such as the Chandra Observatory, utilized reflectors made from zerodur which were up to 20mm thick. The thickness of the reflector as… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to develop bioactive, high-strength contrast agents for use in orthopedic and bone implant applications. There is a clear clinical need for improved contrast agents that increase the strength, toughness and abrasion wear of… more
Abstract:This Small Business Innovation Research Phase-I project will address the development of modified sophorolipid (MSL) surfactant molecules by simple and scalable modification of natural SLs adopting "green chemistry principles". Natural SLs will be produced through fermentation with yeast… more
Abstract:This Small Business Innovation Research Phase I project is designed to evaluate a novel interphase nanocoating designed for Silicon Carbide (SiC) fibers, which is intended to behave as a biomimetic immune system for high-temperature Ceramic Matrix Composites (CMCs) exposed to an oxidizing… more
Abstract:Today the evaluation methods employed in the development and assessment of soldier borne Personal Protective Equipment (PPE) system designs are often extremely slow, expensive, and subjective, resulting in significant delays and expense in the fielding of improved designs. Recent rapid advancements… more
Abstract:A Compact Bidirectional Acoustic Airflow Meter has been developed for gas turbine and other applications. Phase I work has resulted in a non-intrusive meter capable of reading gas flows at high speed in either direction, with a dynamic range exceeding 1000:1. A ruggedized, high-temperature version… more
Abstract:The effectiveness of synchrotron radiation science has been hindered by the limited availability of advanced diagnostics. In many cases, the capability to produce photon fluxes has outpaced the ability to detect and measure the resultant photons. Synchrotron applications are becoming more… more
Abstract:Modern synchrotrons are providing higher beam currents and demanding more RF power from the superconducting cavities. The maximum RF power available without beam is limited by the maximum power rating of the WR1800 waveguide RF ceramic window used in the fundamental power coupler. Operation at… more
Abstract:Because of the need to operate in a space-charge-dominated regime, the generation and preservation of femtosecond electron beams is a major challenge for chemical dynamics and accelerator technology R & amp;D. Electrons from a photo-cathode radio frequency (RF) gun can be used as scattering … more
Abstract:Photocathodes have been the focus of intense experimental and theoretical development for many decades, and their use in RF photoinjectors has been indispensible for the evolution of light sources such as free-electron lasers. At present there is a significant science and technology gap for… more
Abstract:ABSTRACT: A direct sensing of stress and fatigue and their visualization is very attractive and has been pursued for decades. Prognostica is a new and unique tracking, sensing, and prognosticating technology that allows for exactly that. Based on the results achieved in the Phase I effort it is… more
Abstract:The chloroperoxidase enzyme from the filamentous fungus Caldariomyces fumago has applications in industrial chemical synthesis and the detection and inactivation of chemical warfare agents. Chloroperoxidase is capable of regio- and enantioselective oxygenations and halogenations of organic… more
Abstract:Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… more
Abstract:Agave BioSystems, with their academic partners at the Mote Marine Laboratory, proposes to develop probiotic pharmaceuticals from indigenous commensal microbes to enhance gastrointestinal health in the bottlenose dolphin (Tursiops truncatus). The dolphin gastrointestinal microbiome will be… more
Abstract:Wound management becomes increasingly challenging due to bacterial infections, especially from epidemic drug-resistant strains. To address this problem, Agave BioSystems proposes to develop a RANT (Rapidly Adaptable Nanotherapeutics) breadboard system built upon the modules successfully established… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims at developing a targeted semantic processing framework for the analysis of online conversations. A particular focus is given to improving the state-of-the art in the design of semi-supervised syntactic and semantic parsers capable… more
Abstract:This proposed research is to investigate and validate Software Defined Radio (SDR) based, multi-function portable network sensing and intrusion detection algorithms suitable for small dismounted radio platforms used to support Command and Control (C2) standard sensor interfaces carried in the field… more
Abstract:We propose to develop and implement a set of algorithms within a unified target characterization and correlation framework capable of operating in a multiple heterogeneous sensor environment where detection, classification, localization and track priority information is exchanged among multiple… more
Abstract:Simulation tools that exist today for prediction of cosite interference in complex RF environments are able to accurately model complex platforms but they are quickly constrained by computational limits on traditional workstations. The focus of this research will be on updating existing… more
Abstract:DESCRIPTION (provided by applicant): Liver fibrosis is a form of scar formation that is found in almost all patients with chronic injury to the liver. Over time it frequently progresses to cirrhosis, an end-stage lethal disease which is the seventh leadingcause of death in the United States and… more
Abstract:DESCRIPTION (provided by applicant): The renin-angiotensin-aldosterone system (RAAS) plays a critical role in renal physiology. Inhibitors of angiotensin-converting enzyme (ACE) or angiotensin receptor blockers (ARB) are the mainstay in the clinical management of renal disorders such as chronic… more
Abstract:DESCRIPTION (provided by applicant): In Phase 1, measuring and characterizing glucose oscillations in yeast cells immobilized on the surface of a glucose sensor was completed. Using this as a model, it was postulated that within the subcutaneous environment, cells (e.g., fibroblasts, adipocytes)… more
Abstract:An emerging consensus in engineering holds that aleatory uncertainty should be propagated by traditional methods of probability theory but that epistemic uncertainty may require methods that do not confuse incertitude with variability by requiring every possibility be associated with a probability… more
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