Abstract:DESCRIPTION (provided by applicant): Alcoholic and non-alcoholic liver fibrosis remains an unsolved challenge for the hepatologist as it can lead to cirrhosis and end-stage liver disease, a life-threatening condition that necessitates liver transplantation. Current therapeutic strategies for the… more
Abstract:DESCRIPTION (provided by applicant): Scleroderma (also known as systemic sclerosis-SSc) is characterized primarily by progressive dermal and vascular fibrosis. Other organs are affected too, including lung, heart, blood vessels, GI and kidney. Many patients who suffer from scleroderma/SSc also have… more
Abstract:DESCRIPTION (provided by applicant): Chronic kidney disease (CKD) remains an unsolved challenge for the nephrologist, as it almost inevitably leads to end-stage renal failure, a life-threatening condition that necessitates renal replacement therapy. Few, if any, of the currently practiced… more
Abstract:DESCRIPTION (provided by applicant): Ischemic Stroke continues to be a major cause of morbidity and mortality in the United States. Currently approved thrombolytic therapy suffers for a narrow therapeutic window and clearly other therapeutic strategies areneeded, such as neuroprotective or… more
Abstract:DESCRIPTION (provided by applicant): Systemic sclerosis (SSc) or diffuse scleroderma is a complex, chronic, autoimmune, connective tissue disease which primarily causes skin thickening and hardening in addition to interstitial fibrosis of lungs, gastrointestinal tract and arteries. Estimates of the… more
Abstract:DESCRIPTION (provided by applicant): Idiopathic pulmonary fibrosis (IPF) is a progressive, agonizing, debilitating and routinely fatal disease that afflicts 200,000 individuals in the United States and five million patients worldwide. There are currentlyno effective treatments available for this… more
Abstract:DESCRIPTION (provided by applicant): Myocardial infarction (MI) is a significant cause of morbidity and mortality in the U.S. H2 Relaxin (H2R) is a Phase III clinical trial-stage peptide that exhibits both anti-inflammatory and cytoprotective activities which can potentially be harnessed for the… more
Abstract:The objective of this project is to develop a portable, passive system for rapid and efficient blood component separation. While a number of macroscale devices (based on centrifugation) are routinely employed in laboratory settings to separate red blood cells (RBCs) and platelets from plasma, they… more
Abstract:DESCRIPTION (provided by applicant): Patient data collected during health care delivery and public health surveys possess a great deal of information that could be used in biomedical and epidemiological research. Access to these data, however, is usually limited because of the private nature of most… more
Abstract:Applied Science Innovations proposes development of metrology on corrective optics for aerodynamic domes using the improved Interferometric Tomography, building directly on ASI's successful development of a new tool for metrology on conformal aspheric windows, domes and corrector optics. The… more
Abstract:Applied Science Innovations proposes Phase II development of metrology on corrective optics for aerodynamic domes using the improved Interferometric Tomography, building directly on ASI"s successful development of a new tool for metrology on conformal aspheric windows, domes and corrector… more
Abstract:This project will develop a decision tool for Load and Route Evaluation for Dismounted Operations (LAREDO). The research efforts will expand upon infantry routing algorithms and decision tools we are developing for the Army"s Geospatial Engineering Center. LAREDO will provide an interactive 3D… more
Abstract:ABSTRACT: Enterprise wide data exfiltration will be prevented by designing and implementing a method to protect files based on logical group membership. Anyone outside that group without the group key(s) will be unable to decrypt the data. Localized Encryption Groups (LEG) will provide an automated… more
Abstract:ABSTRACT: AIS, Inc. proposes the Cyber Battlefield Training and Effectiveness Environment (CBTEE) project to develop a prototype training environment with integrated sensor technology tailored at training cyber warriors in rapidly evolving cyber battlefield. The CBTEE will utilize state of the art… more
Abstract:Solid-state storage media, particularly solid-state drives (SSDs), present new challenges to forensic investigation that need to be addressed. The lowlevel
behavior of these drives is dramatically different than for mechanical hard disk drives-including what low-level data is available, how that… more
Abstract:The protocols needed to coordinate the activities of distributed components, such as consensus algorithms, are notoriously difficult to design, implement, and verify. Abstraction is the only way to gain intellectual control over this complex problem; so ATC-NY and Cornell University have developed… more
Abstract:DESCRIPTION (provided by applicant): ClotFoam(R) , is a novel adhesive sealant composition and second-generation hemostatic agent. This biological agent was designed to arrest moderate to severe blood loss arising from intracavitary traumatic injury orintraoperative hemorrhage without compression… more
Abstract:DESCRIPTION (provided by applicant): Lyme disease is the most common vector borne infectious disease in North America and Europe. It is a progressive disease with a wide array of clinical manifestations. Treatment of early infection is highly effective, and early diagnosis and treatment are critical… more
Abstract:DESCRIPTION (provided by applicant): Most preterm infants have episodes of apnea (cessation of breathing), bradycardia (low heart rate), and desaturations (low levels of oxygen in the blood) or what is collectively called as ABD events. The resolution of such ABD episodes depends to a large extent… more
Abstract:ABSTRACT: Development and deployment of airborne multistatic radar systems and the algorithms that control them can be greatly aided by accurate modeling and performance prediction. Capturing physical, electromagnetic and environmental real-world effects of multistatics in a simulation capability… more
Abstract:ABSTRACT: In today"s war environment, our leaders are generating more Requests for Information to support the fight than ever and the MOVINT sensors providing beneficial information to service these requests are growing in number and capability and thus data volume is increasing. To… more
Abstract:Phase II.5 of the Airborne Parasitic Bistatic Radar (APBR) program will demonstrate successful operation of the APBR system on multiple airborne platforms in varying clutter environments. The objective of the Airborne Parasitic Bistatic Radar (APBR) program is to develop a compact airborne PC-based… more
Abstract:ABSTRACT: Wind tunnels are used as an important tool to understand the aerodynamics of aircraft. Wind tunnel models are typically instrumented with balances that are capable of measuring the forces and moments that an aircraft will be subjected. Along with measuring these forces and moments… more
Abstract:DESCRIPTION (provided by applicant): The science of protecting avulsed teeth has progressed little in the past 10 years. While commercial solutions are available, most simply consist of a pH balanced salt solution. Several peer-reviewed citations in the last two years have compared the efficacy of… more
Abstract:DESCRIPTION (provided by applicant): There is increasing utilization of flow cytometry in both basic and applied research to accomplish diagnostic assays. One such area of research is the investigation of circulating cells that have detached from tumors. Another very active and contemporary area is… more
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