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Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for… more
Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial therapeutics by inhibiting… more
Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of antimicrobial agents… more
Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: With no clinically approved antiviral therapy available for treatment of flavivirus infections, the development of efficient vaccines and antiviral agents for prevention and treatment of infections is an urgent health priority. A combination of structure-based in silico models, in vitro and… more
Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… more
Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental… more
Company: ANDRO Computational Solutions, LLC Agency/Program/Year/Phase: DOD / STTR / 2012 / 1
Abstract: ABSTRACT: Within the last decade, game theoretic approaches have emerged as viable tools to analyze distributed wireless resource allocation problems and design distributed transmission strategies. Conventional game theoretic designs for wireless resource allocation problems do not consider jamming… more
Company: ANDRO Computational Solutions, LLC Agency/Program/Year/Phase: DOD / STTR / 2012 / 2
Abstract: ABSTRACT: The ultimate objective of the joint effort is to develop technology that will enable next-generation cognitive wireless networking between USAF space, air, and ground assets and achieve significant improvement in network throughput, delay, and reliability. Current practices that evolve… more
Company: ANGION BIOMEDICA CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Alcoholic and non-alcoholic liver fibrosis remains an unsolved challenge for the hepatologist as it can lead to cirrhosis and end-stage liver disease, a life-threatening condition that necessitates liver transplantation. Current therapeutic strategies for the… more
Company: ANGION BIOMEDICA CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Scleroderma (also known as systemic sclerosis-SSc) is characterized primarily by progressive dermal and vascular fibrosis. Other organs are affected too, including lung, heart, blood vessels, GI and kidney. Many patients who suffer from scleroderma/SSc also have… more
Company: ANGION BIOMEDICA CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Chronic kidney disease (CKD) remains an unsolved challenge for the nephrologist, as it almost inevitably leads to end-stage renal failure, a life-threatening condition that necessitates renal replacement therapy. Few, if any, of the currently practiced… more
Company: ANGION BIOMEDICA CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Ischemic Stroke continues to be a major cause of morbidity and mortality in the United States. Currently approved thrombolytic therapy suffers for a narrow therapeutic window and clearly other therapeutic strategies areneeded, such as neuroprotective or… more
Company: ANGION BIOMEDICA CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Systemic sclerosis (SSc) or diffuse scleroderma is a complex, chronic, autoimmune, connective tissue disease which primarily causes skin thickening and hardening in addition to interstitial fibrosis of lungs, gastrointestinal tract and arteries. Estimates of the… more
Company: ANGION BIOMEDICA CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Idiopathic pulmonary fibrosis (IPF) is a progressive, agonizing, debilitating and routinely fatal disease that afflicts 200,000 individuals in the United States and five million patients worldwide. There are currentlyno effective treatments available for this… more
Company: ANGION BIOMEDICA CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Myocardial infarction (MI) is a significant cause of morbidity and mortality in the U.S. H2 Relaxin (H2R) is a Phase III clinical trial-stage peptide that exhibits both anti-inflammatory and cytoprotective activities which can potentially be harnessed for the… more
Company: Antek Agency/Program/Year/Phase: DOD / STTR / 2012 / 2
Abstract: The objective of this project is to develop a portable, passive system for rapid and efficient blood component separation. While a number of macroscale devices (based on centrifugation) are routinely employed in laboratory settings to separate red blood cells (RBCs) and platelets from plasma, they… more
Company: APPLIED BIOMATHEMATICS INC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Patient data collected during health care delivery and public health surveys possess a great deal of information that could be used in biomedical and epidemiological research. Access to these data, however, is usually limited because of the private nature of most… more
Company: Applied Science Innovations, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Applied Science Innovations proposes development of metrology on corrective optics for aerodynamic domes using the improved Interferometric Tomography, building directly on ASI's successful development of a new tool for metrology on conformal aspheric windows, domes and corrector optics. The… more
Company: Applied Science Innovations, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: Applied Science Innovations proposes Phase II development of metrology on corrective optics for aerodynamic domes using the improved Interferometric Tomography, building directly on ASI"s successful development of a new tool for metrology on conformal aspheric windows, domes and corrector… more
Company: Applied Visions, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: This project will develop a decision tool for Load and Route Evaluation for Dismounted Operations (LAREDO). The research efforts will expand upon infantry routing algorithms and decision tools we are developing for the Army"s Geospatial Engineering Center. LAREDO will provide an interactive 3D… more
Company: ASSURED INFORMATION SECURITY, INC. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: ABSTRACT: Enterprise wide data exfiltration will be prevented by designing and implementing a method to protect files based on logical group membership. Anyone outside that group without the group key(s) will be unable to decrypt the data. Localized Encryption Groups (LEG) will provide an automated… more
Company: ASSURED INFORMATION SECURITY, INC. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: ABSTRACT: AIS, Inc. proposes the Cyber Battlefield Training and Effectiveness Environment (CBTEE) project to develop a prototype training environment with integrated sensor technology tailored at training cyber warriors in rapidly evolving cyber battlefield. The CBTEE will utilize state of the art… more
Company: ATC - NY Agency/Program/Year/Phase: DHS / SBIR / 2012 / 1
Abstract: Solid-state storage media, particularly solid-state drives (SSDs), present new challenges to forensic investigation that need to be addressed. The lowlevel
behavior of these drives is dramatically different than for mechanical hard disk drives-including what low-level data is available, how that… more
Company: ATC - NY Agency/Program/Year/Phase: NASA / SBIR / 2012 / 1
Abstract: The protocols needed to coordinate the activities of distributed components, such as consensus algorithms, are notoriously difficult to design, implement, and verify. Abstraction is the only way to gain intellectual control over this complex problem; so ATC-NY and Cornell University have developed… more
Company: BIOMEDICA MANAGEMENT CORP. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): ClotFoam(R) , is a novel adhesive sealant composition and second-generation hemostatic agent. This biological agent was designed to arrest moderate to severe blood loss arising from intracavitary traumatic injury orintraoperative hemorrhage without compression… more
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