Abstract:DESCRIPTION (provided by applicant): This project develops an automated protein preparation technology that uses magnetic microparticles to isolate histones in their native state from specific genomic loci of interest via the chromatin to which they are bound. After extraction, the targeted histones… more
Abstract:Breast cancer is a leading cause of malignancies in women, resulting in almost 200,000 new cases every year. In approximately one third of breast cancer patients, malignant cells spread to distant organs and cause metastatic tumors. Tumor progression, metastatic spread and patient prognosis depends… more
Abstract:DESCRIPTION (provided by applicant): For longitudinal field studies involving substance abusers, successfully tracking, locating, and following up with a representative sample of subjects is a challenge. One meta-analysis of 85 longitudinal studies of substance abuse clients found that nearly… more
Abstract:DESCRIPTION (provided by applicant): This Phase I application is being submitted with the main objective to develop a highly sensitive and specific imaging method for prostate cancer that is based on a bispecific antibody (bsMAb) pretargeting procedure. The key features of this imaging system is the… more
Abstract:DESCRIPTION (provided by applicant): The main objective of this Phase I SBIR application is to perform the first-in-man studies with a new antibody-drug conjugate (ADC) composed of a humanized antibody (hRS7) to the epithelial glycoprotein-1 antigen (EGP-1, also known as TROP-2) coupled to SN-38,… more
Abstract:The Department of Energy is seeking ancillary technologies to enhance the performance of high filed superconducting materials critical for the very high-field magnets to be used in a future particle accelerator. Bi-2212 round wire, a high temperature superconductor, is one of the best candidates for… more
Abstract:DESCRIPTION (provided by applicant): This project consists of the research and development of a unique implantable ischemia monitor that uses subcutaneous sensors in the patient's torso to detect the onset of acute myocardial infarction (AMI). Upon detecting a heart attack, the monitor… more
Abstract:ABSTRACT: JMSI Inc (DBA Intelligent Light) proposes to develop EPISODE - a new large scale data management tool that enables an engineer to more readily extract knowledge and insight from their large scale physics based simulations and experimental data. The Extract Plug-In Scalable reduced Order… more
Abstract:Intelligent Light, the makers of the commercially available Computational Fluid Dynamics post- processing software FieldView proposes, under the SBIR project under Topic 2c, & quot;Hardening of an R & amp;D Code for Industry Use & quot;, to integrate and commercialize the VisIt &… more
Abstract:The technology developed under this STTR is a system to monitor solider metal state and performance. The objective of this project is to develop a real-time human mental state detection system from non-intrusive thermal and visual facial video. We propose
Abstract:ABSTRACT: Power amplifiers (PAs), providing high linearity and efficiency, are essential for transmission of high data rate bandwidth efficient digital signals. Achieving this objective at millimeter-wave (MMW) is particularly challenging. LTI with L-3 EDD are teaming to develop a PA for 81-86… more
Abstract:LTI has extensive experience producing analog predistortion linearizers for microwave and millimeter-wave bands. Its linearizers are higher order linearizers, based on correcting a PA"s transfer characteristics without cancelling specific order IMD products. LTI designs when integrated with… more
Abstract:This Small Business Innovation Research Phase II proposal to the Department of Defense requests $749,982 for continuation of research and scale up of technology to carburize, nitride or carbonitride surfaces of tailhook shoes. The proposal is for continuation of work in Phase I Option Award… more
Abstract:Next generation DoD electronic warfare (EW) and commercial communication systems are currently faced with the challenge of delivering a receiver capable of multi-band reception. The receiver must meet various wireless standards and cover an expanse of frequencies and bandwidths. Traditionally the… more
Abstract:ABSTRACT: As the size, cost, and power consumption of digital signal processing platforms continue to drop and their performance improves, incorporating digital beamformer (DBF) designs into future SATCOM satellite payloads has become an increasingly attractive approach. The advantages offered by… more
Abstract:ABSTRACT: MaXentric and the University of California propose using AlGaN/GaN HEMT devices, quasi-optical combining with meta-materials, and linearization techniques. MaXentrics millimeter wave electronics focus on a new and promising architecture called meta-material in a tiled or tray active array… more
Abstract:The Ka-/Q-band satellite systems offer potential for transportable and mobile communications through the effective use of the wide bandwidths available while requiring that adequate linearity performance be maintained. In environments where size and power conservation is of high importance, power… more
Abstract:Secure data storage in tactical wireless mesh networks is mainly addressed by encryption of sensitive data using shared key concepts combined with encrypted wireless links. The nature of the applications (e.g. a situational awareness application among 10-100 nodes) leads to each mesh node sharing… more
Abstract:For many years, electrically driven heat pumps have proven to be an effective method of extracting heat from ambient air. As air temperature falls, however, heat pump performance falls off, essentially limiting their year round usefulness to warmer climates. In colder climates heat pump-equipped… more
Abstract:Mechanical Solutions, Inc. (MSI) is proposing to modify its existing extended range 40mm non-lethal munition to carry a molecularly imprinted polymer (MIP) payload to detect and confirm explosives at a stand-off distance of 100 meters. The MIP is accurately delivered and distributed with very low… more
Abstract:ABSTRACT: The overall goal for this project is to develop and validate a robust online blade vibration and tip clearance measurement system for compressor and turbine blades, and to transition that technology to engine control system manufacturers, thereby improving engine performance, cost, and… more
Abstract:ABSTRACT: The goal of the Phase II SBIR project is to develop a practical valve health monitoring system for control valves that are utilized at AEDC facilities. The technical problem addressed is the impact of unplanned valve maintenance or valve failure on wind tunnel operations at AEDC. Valve… more
Abstract:The project goal is to enable the electrical outputs of multiple, very compact turbogenerators in the 10-50 kW range to be combined ("mechanically paralleled") in order to create a compact, stable, reliable, and efficient microgrid capable of providing up to 500 kW… more
Abstract:A particular need exists for systems to accurately orient mortar gun tubes in the field. Specifically, a system is sought that is compact enough to be man portable and fit on a 60 or 81 mm mortar barrel, capable of withstanding lateral shock up of 3 -15,000G, be able to resolve azimuth and elevation… more
Abstract:As part of the spacesuit pressure garment, the EVA glove incorporates a silicone pad on the palm for protection of the bladder from cuts and punctures. Repeated gripping and rotational motion cause delamination of the silicone pad from the underlying Vectran® fabric. In addition, frequent scuffing… more
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