Abstract:DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop a novel quantitative particle agglutination technology for improving the performance of blood typing assays. The conventional hemagglutination blood typing assays have serious drawbacks such as limited… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to develop a novel quantitative flow through cell counting method for enumeration of CD4+ T lymphocytes in human blood. CD4 cell counts are needed to stage and monitor HIV-infected patients. In adults, the absolute… more
Abstract:This proposal is directed toward Focus Area 1: Low noise high sensitivity and high bandwidth detector arrays at 1µm. Amplification Technologies Inc. has invented and demonstrated a fundamentally new technology to design and fabricate high-sensitivity photodetectors. We invented an amplification… more
Abstract:The focus of this SBIR project is to develop a low cost novel structured metal bipolar plate technology for low temperature PEM fuel cells for transportation applications. The innovative metal bipolar plate technique is aimed to meet industry revised performance and cost requirements for metal… more
Abstract:DESCRIPTION (provided by applicant): Dehydration is a frequent cause of morbidity and mortality in the elderly. Identifying at risk individuals and maintaining adequate fluid balance is an essential component of health care in aging population. Currently,there is no effective tool available to… more
Abstract:DESCRIPTION (provided by applicant): Pelvic organ prolapse is a highly prevalent condition affecting at least 50% of women in the US during their lifetimes. Some loss of utero-vaginal support occurs in most adult women, however, the true etiology of prolapse and differences seen among individuals is… more
Abstract:Training in the symptoms of Spatial Disorientation (SD) has shown to be valuable in aiding pilots to recognize its onset and provide a means for mitigating its effects, but such demonstrations have traditionally been associated with specialized equipment and devices. Since the vast majority of… more
Abstract:ABSTRACT: Current generation engines for Air Force platforms provide unprecedented levels of thrust and performance but also generate significantly higher jet exhaust noise than legacy tactical aircraft. Phase I work at CDI has identified first-generation actuation devices that can be tailored to… more
Abstract:Conceptual design tools for rotorcraft are used to size vehicles for intended flight operations, as well as reveal trends on the relative benefits certain configuration choices have on the resulting aircraft performance. This information is useful for indicating potentially valuable areas for… more
Abstract:Accurate flow calculation is crucial to the development and support of air platforms, and CFD has been successful at predicting aerodynamic performance for a variety of flows. The accuracy of CFD is governed by the quality of the surface mesh, and much work has been undertaken to automatically… more
Abstract:ABSTRACT: Requirements for enhanced cruise efficiency and reduced noise for future Air Force mobility transports can be met using advanced propeller and propfan technology. However, identifying designs that balance performance and acoustics requirements for multiple flight conditions poses a… more
Abstract:ABSTRACT: Discovery Semiconductors will assemble high power InGaAs/InP photodiodes with 50 ohm internal termination in a fiber-pigtailed, W1-connectorized microwave package having the following specifications: (a) Responsivity>0.7 A/W at 1550 nm wavelength; (b) -3 dB Bandwidth>60 GHz; (c)… more
Abstract:Phthalates are a class of petroleum-derived chemicals used as plasticizers to improve the properties of polymeric materials like PVC. However, they are currently being phased out of use in the US and elsewhere due to concerns about their toxicity and action as endocrine disruptors. One viable… more
Abstract:DESCRIPTION (provided by applicant): The primary care goal during a heart attack is to quickly restore blood perfusion. Reperfusion, however, is paradoxical, while it enables organ survival; it also enables destructive biochemical processes. While numerousadjunctive therapies for acute myocardial… more
Abstract:The objective of this SBIR Phase I proposal is to develop a lightweight, cost-effective, and high-temperature resistant portable helipad for future helicopters and vertical landing aircrafts. Portable helipads are critical for forward operating bases, and enable aircrafts to land in any area safely… more
Abstract:DESCRIPTION (provided by applicant): Project Summary Mechanical cardiac support has been shown to be an effective treatment in adults that suffer from congestive heart failure; however, there are limited options for treatment for the smallest of patientsthat present with heart failure. In the U.S.,… more
Abstract:DESCRIPTION (provided by applicant): Project Summary Development towards treating small children and infants with mechanical circulatory support systems to bridge to transplant purposes is underway. However, implantable systems with miniaturized external components have delayed the process. To date,… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this SBIR application is to initiate a clinical trial with a bispecific antibody (bsMAb) pretargeting procedure for detecting pancreatic carcinoma, based on a highly specific antibody (PAM4) recognizing an epitope found in pancreatic mucin.… more
Abstract:DESCRIPTION (provided by applicant): Triple-negative breast cancer (TNBC) is a subset of breast cancers with poor prognosis and high mortality due to the lack of effective therapeutic regimens. This Phase I SBIR application is to develop E1-Rap, a novel immunoRNases, for treating TNBC. E1-Rap is a… more
Abstract:DESCRIPTION (provided by applicant): The main goal of this Phase I/II SBIR application is to translate rapidly preclinical findings that show the advantage of using a combination radioimmunotherapy plus immunotherapy treatment regimen that uses non-competing antibodies for the improved treatment… more
Abstract:Many U.S. manufacturers need advanced simulation tools to maintain competitiveness in the world marketplace. The Department of Energy has developed several advanced simulation codes that could help, but the tools are too difficult for engineers in U.S. industry to use. VisIt is one such code that… more
Abstract:This SBIR Phase I proposal is aimed at the development of the ultra-sensitive detector for the far infrared (FIR) and terahertz (THz) bands of electromagnetic radiation. The device is inherently optical, operates at room temperature and of submillimeter size. The proposed technology is based on… more
Abstract:We propose to design and implement a system that combines multiple audio transcription and multiple translation tools with natural language processing capabilities, such that information can be automatically extracted from audio files with improved performances. In our approach, speech waveforms of… more
Abstract:DESCRIPTION (provided by applicant): Recent advances in photoacoustic tomography (PAT) have demonstrated its potential for 3D noninvasive high resolution imaging of soft tissues at penetration depths of many centimeters. Further, and perhaps even more importantly, imaging of tissue structure can be… more
Abstract:Linearizer Technology Inc. produces analog predistortion linearizers. Integrated with a power amplifier (PA) and used for SATCOM applications they approach the performance of an ideal amplifier. Limitations of LTI's linearizers are the need for meticulous tuning to achieve the desired… more
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